Management of Craniosynostosis

Abstract

Many procedures exist for treatment of craniosynostosis. The goal of all surgical interventions is to correct the skull deformities associated with the synostosis and to prevent the sequela of elevated intracranial pressure. Open cranial vault reconstructions address these issues at the time of surgery, but have the potential for increased blood loss and longer hospital stays. Minimally invasive procedures have shorter operative times and decreased blood loss, but rely on the cranial abnormality to improve over time with helmets or distraction devices. Prolonged follow-up is necessary to monitor long-term cosmetic outcomes and evaluate for signs of increasing intracranial pressure.

Pfeiffer syndrome: oral healthcare management and description of new dental findings in a craniosynostosis

“…Management of Pfeifer syndrome should aim to improve the quality of life of affected patients. At present, treatment of Pfeiffer syndrome is largely symptomatic and based on multiple‐stage surgical interventions to correct associated skeletal defects . However, targeting the aberrant FGFR signaling using specific molecular inhibitors may provide a promising future therapeutic strategy …”

Anthropometric Cranial Measurements in Metopic Craniosynostosis/Trigonocephaly: Diagnostic Criteria, Classification of Severity and Indications for Surgery

“…It is the result of premature metopic suture fusion and is the second most frequent type of single suture craniosynostosis. [1][2][3] The majority of trigonocephaly cases are sporadic but it can be syndromic in nature in around 35% of cases. 4 Trigonocephaly may have the most varied phenotypic presentation of the various craniosynostosis due to its limited role in frontal bone growth in infancy.…”

Real-Time Tool Detection for Workflow Identification in Open Cranial Vault Remodeling

“…Despite the number of surgical procedures in which AI has improved workflow analysis, up to our knowledge, no studies have applied these techniques to open cranial vault remodeling for the correction of craniosynostosis. Craniosynostosis is a congenital defect that implies the premature fusion of one or more cranial sutures that separate the skull bones [ 13 ]. This condition may be induced by genetic, teratogenic, or mechanical causes or can even arise sporadically [ 14 ].…”