Management of COVID-19 in comorbidities

Abstract

As the main title ‘COVID-19 revolution: a new challenge for the internist’ states, the global coronavirus infection disease 2019 (COVID-19) pandemic represented a new challenge for the internists. This paper is part of a series of articles written during the difficult period of the ongoing global pandemic and published all together in this fourth issue of the Italian Journal of Medicine, with the aim of sharing the direct experiences of those who were the first to face this severe emergency, expressing each point of view in the management of COVID-19 in relation to other diseases. Each article is therefore the result of many efforts and a joint collaboration between many colleagues from the Departments of Internal Medicine or Emergency Medicine of several Italian hospitals, engaged in the front line during the pandemic. These preliminary studies therefore cover diagnostic tools available to health care personnel, epidemiological reflections, possible new therapeutic approaches, discharge and reintegration procedures to daily life, the involvement of the disease not only in the lung, aspects related to various comorbidities, such as: coagulopathies, vasculitis, vitamin D deficiency, gender differences, etc.. The goal is to offer a perspective, as broad as possible, of everything that has been done to initially face the pandemic in its first phase and provide the tools for an increasingly better approach, in the hope of not arriving unprepared to a possible second wave. This paper in particular deals with the management of COVID-19 in comorbidities.

Long-term exposure to PM10 above WHO guidelines exacerbates COVID-19 severity and mortality

“…Our random forest model showed the importance of the long-term exposure to PM 10 on the COVID-19 severity and mortality prognosis versus other clinical variables clearly stated as comorbidities, such as COPD/asthma , cancer , diabetes and obesity, among others ( Cardamone and Donatiello, 2020 , Kong et al, 2021 , McGurnaghan et al, 2020 , Mohammad et al, 2021 , Oh and Song, 2021 ). Notwithstanding, we also found that age, sex (male) and obesity significantly increased the severity of COVID-19, which is in agreement with other studies ( Elezkurtaj et al, 2021 ).…”

Susceptibility to Metabolic Diseases in COVID-19: To be or Not to be an Issue

“…Since December 2019, the Coronavirus Disease-19 (COVID-19) pandemic has become the most challenging issue throughout the world. Many studies have been done on the nature of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) and its therapeutic strategies (Cardamone and Donatiello 2020;Schlosser et al, 2020).…”