Management of Cough in Patients with Chronic Obstructive Pulmonary Disease: Results of the Multicenter Randomized Placebo-Controlled Clinical Trial

Avdeev, S. N.; Визель, А. А.; Абросимов, В. Н.; Zaicev, Andrey A; Игнатова, Г. Л.; Хамитов, Р. Ф.; Mikhaylusova, M. P.; Shapovalova, Julia; Павлыш, Е. Ф.; Trofimov, B I; Emelyanov, Alexander; Мартыненко, Т. И.; Martynenko, Vladimir A; Kostina, N. E.; Chizhov, Danila A; Chizhova, O. Yu.; Кузубова, Н. А.; Makova, Elena V; Makarova, E. V.

doi:10.2147/copd.s292109

Cited by 6 publications

(4 citation statements)

References 22 publications

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“…Lactose is an important component of drugs which active pharmaceutical ingredients are obtained by repeated dilution of antibodies. These drugs are effective and safe in the treatment of many diseases [20][21][22][23][24][25][26][27]. Although previous studies already showed the differences between lactose saturated with dilutions of substances from control [3,[6][7][8][9][10], the development of comprehensive methods of quality control of such drugs is still an urgent task.…”

Section: Introductionmentioning

confidence: 99%

Optical Properties of Crystalline Lactose Fluidized with Dilutions of Various Substances in the Terahertz Frequency Range

et al. 2021

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Lactose is a commonly used component of pharmaceutical medications in tablet form. It was previously shown that lactose changes conformationally after saturation in fluidized beds with active pharmaceutical ingredients obtained by repeated dilution of antibodies to interferon-gamma in combination with an external intensive vibration treatment. Moreover, it was revealed that these solutions are self-organized dispersed systems in which nano-objects are formed. Their biological activity and mechanism of action were previously established as well. The current work was dedicated to investigating the optical properties of fluidized lactose powders in the terahertz frequency range. Spectral analyses of powders of crystalline lactose saturated in fluidized beds with a diluted solution of either glycine buffer, antibodies to interferon-gamma, or water were carried out, intact lactose served as a control. All powders were tableted before testing. In the course of the study, the macroscopic parameters of the tablets were established, at which they had a stable shape and their THz optical properties had no parasitic diffraction losses. These tablets were analyzed using terahertz time-domain spectroscopy in the frequency range of 0.2–2.6 THz. The differentiation between the spectra was conducted using a principal component analysis. The differences between intact lactose and the lactose saturated with any of studied solutions were demonstrated. Additionally, lactose saturated with solutions of multiple dilutions of a substance (antibodies or glycine buffer) differed not only from intact lactose, but also from lactose saturated with a diluted solution of water. Moreover, discrimination of lactose formulations saturated with different substances (antibodies or glycine buffer) was also possible. Additionally, intact lactose differed from lactose saturated with diluted water. The methods reported could be useful for the quality control of the medications based on the technology of repeated dilution of an original substance.

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Section: Introductionmentioning

confidence: 99%

Optical Properties of Crystalline Lactose Fluidized with Dilutions of Various Substances in the Terahertz Frequency Range

et al. 2021

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“…4), может быть оправдано только в случае сухого кашля, значительно снижающего качество жизни пациента (кашель нарушает сон, снижает дневную активность, сопровождается болевым синдромом). действие, сравнимое с эффектом кодеинсодержащих препаратов, а также эффективность в купировании кашля при острых и хронических процессах [49,50].…”

Section: общие лечебные подходы к ведению пациента с кашлемunclassified

Cough

Zaitsev,

Budnevsky,

Brodskaya

2024

Респираторная Медицина : Руководство : В 4 Т. 3-Е Изд., Доп. И Перераб. Т. 1.

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“…Namun, pendekatan yang dipersonalisasi dan berfokus pada pasien berdasarkan pemahaman tentang mekanisme yang mendasari dapat menghasilkan manfaat yang berarti bagi banyak orang (O'Donnell et al, 2020). Batuk kronis seringkali merupakan gejala pertama PPOK, dan dianggap remeh oleh pasien dan dianggap sebagai konsekuensi yang diharapkan dari merokok atau efek lingkungan (Avdeev et al, 2021) Hal ini akan mengakibatkan peningkatan saturasi oksigen (SaO2), peningkatan tekanan parsial oksigen dalam darah (PaO2), dan penurunan tekanan parsial karbon dioksida dalam darah (PaCO2) serta peningkatan volume tidal yang lebih besar, perekrutan otot ekspirasi dan penurunan laju pernapasan (RR). Setelah pemberian intervensi latihan pernapasan PLB terjadi penurunan frekunesi pernapasan dengan rentang 4-5 angka dan saturasi oksigen dapat dipertahankan yaitu 96% tanpa terapi oksigen sejalan dengan penelitian yang dilakukan Widoroni et al, (2021) yang menunjukkan bahwa nilai skala sesak napas p value 0,018, dan saturasi oksigen p value 0,023, maka dapat disimpulkan pemberian intervensi PLB dapat menjadi intervensi yang baik dilakukan.…”

Section: Pendahuluanunclassified

Intervensi Latihan Pernapasan Pursed Lip Breathing dan Batuk Efektif Pada Pasien dengan Ppok: Studi Kasus

Umiah,

Platini,

2024

Mal Health Stu J.

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Chronic obstructive pulmonary disease (COPD) is a disease characterized by progressive airflow limitation and progressive destruction of lung tissue. COPD risk factors are smoking and age. This study was conducted to determine the effect of pursed lip breathing and effective coughing on COPD patients. The patient in this case report is a 60-year-old man with health complaints in the form of a cough that is not accompanied by phlegm and shortness of breath that increases when the patient is active. Nursing problems in patients are ineffective airway clearance associated with accumulation of mucus and excess secretions characterized by ineffective coughing, excess sputum, rhonchi sounds in the vesicular area. The results obtained in this study using non-pharmacological intervention methods used for symptom management in patients with COPD, namely pursed lip breathing and coughing, are effective in reducing symptoms of shortness of breath, although the decrease is not significant. After administering the intervention the patient's mMRC scale was 3 and the change in the COPD Assessment Test (CAT) score was 20 which means Moderate, COPD interferes with the patient's daily activities, respiratory frequency decreases and oxygen saturation can be maintained. The effect of effective physiotherapy and coughing accompanied by breathing exercises shows an increase in quality of life and reduces the symptoms felt by the patient. This intervention can be an alternative option to be carried out independently at home without using costs. Keywords: Chronic Obstructive Pulmonary Disease, Effective Cough Exercise, Pursed Lip Breathing ABSTRAK Penyakit paru obstruktif kronik (PPOK) merupakan penyakit yang ditandai dengan keterbatasan aliran udara progresif hingga kerusakan jaringan paru. Faktor risiko PPOK yaitu merokok dan usia. Penelitian ini dilakukan untuk mengetahui pengaruh latihan pernapasan pursed lip breathing dan batuk efektif pada pasien PPOK. Pasien dalam laporan kasus ini adalah seorang laki-laki berusia 60 tahun dengan keluhan kesehatan berupa batuk yang tidak disertai dahak dan sesak yang bertambah ketika pasien beraktifitas. Masalah keperawatan pada pasien yaitu bersihan jalan napas tidak efektif berhubungan dengan penumpukan lendir dan sekresi berlebih ditandai dengan batuk tidak efektif, sputum berlebih, terdengar bunyi ronchi di area vesikuler. Hasil yang didapatkan pada penelitian ini dengan menggunakan metode intervensi non farmakologis yang digunakan untuk manajemen gejala pada pasien dengan PPOK yaitu latihan pernapasan pursed lip breathing dan batuk efektk mampu mengurangi gejala sesak meskipun penurunannya tidak signifikan. Setelah pemberian intervensi skala mMRC pasien yaitu 3 dan perubahan pada skor COPD Assessment Test (CAT) yaitu 20 yang artinya Sedang, PPOK menggangu aktivitas sehari-hari pasien,frekuensi napas menurun dan saturasi oksigen dapat dipertahankan. Efek fisioterapi dan batuk efektif yang disertai latihan pernapasan menunjukkan peningkatan kualitas hidup dan menurunkan gejala yang dirasakan pasien. Intervensi ini dapat menjadi salah satu pilihan alternatif untuk dilakukan secara mandiri di rumah tanpa menggunakan biaya. Kata Kunci: Chronic Obstructive Pulmonary Disease, Effective Cough Exercise, Pursed Lip Breathing

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Management of Cough in Patients with Chronic Obstructive Pulmonary Disease: Results of the Multicenter Randomized Placebo-Controlled Clinical Trial

Cited by 6 publications

References 22 publications

Optical Properties of Crystalline Lactose Fluidized with Dilutions of Various Substances in the Terahertz Frequency Range

Optical Properties of Crystalline Lactose Fluidized with Dilutions of Various Substances in the Terahertz Frequency Range

Cough

Intervensi Latihan Pernapasan Pursed Lip Breathing dan Batuk Efektif Pada Pasien dengan Ppok: Studi Kasus

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