Management of Coronary Artery Disease

Chi

et al. 2022

JCDD

Objective: The aim of this study is to assess the association between epicardial adipose tissue (EAT) and coronary artery disease (CAD) via meta−analysis. Methods: Specific searches of online databases from January 2000 to May 2022 were conducted. All observational studies evaluating the association between EAT and CAD in PubMed, Web of Science, and the Cochrane Library databases were screened. A meta-analysis was conducted following the Preferred Reporting Items for Systematic Reviews and Meta−Analyses guidelines (PRISMA). In total, 21 studies encompassing 4975 subjects met the inclusion criteria, including 2377 diagnosed and assigned as the CAD group, while the other 2598 were assigned as the non−CAD group. Subjects in the CAD group were further divided into the severe stenosis group (stenosis ≥ 50%, n = 846) and the mild/moderate stenosis group (stenosis < 50%, n = 577). Results: Both the volume and thickness of EAT in the CAD group were larger compared to the non−CAD group (p < 0.00001). In a subgroup analysis within the CAD group, the severe stenosis group had a larger volume and thickness with respect to EAT when compared to the mild/moderate group (p < 0.001). Conclusions: The enlargement of EAT presented in CAD patients with an association with CAD severity. Although limited by different CAD types and measuring methods for EAT, as well as a smaller sample size, our results suggest that EAT is a novel predictor and a potential therapeutic target for CAD.

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Epicardial Adipose Tissue in Patients with Coronary Artery Disease: A Meta-Analysis

Chi

et al. 2022

JCDD

Measurement and Control

“…is also apparently held true such that dV dt = 0. Case 3: For 0 \ s \ 1, there exists jsj \ s 1 3 . In order to have dV dt 40, not only the value of k 1 is larger than e Ã d , but also k 1 has to be as large as possible to assure k 1 jsj5e Ã d s…”

Section: Stability Analysismentioning

confidence: 99%

“…Case 4: For s = 1, there exists jsj = s 1 3 . Similarly, the value of k 1 needs to be larger than e Ã d to assure k 1 .…”

Section: Stability Analysismentioning

confidence: 99%

See 1 more Smart Citation

Sliding-mode-based chaos suppression of coronary artery systems

Ding

Qian

Lee

et al. 2023

Since coronary artery disease is the leading global cause of mortality and morbidity, this paper investigates the chaos suppression of coronary artery systems. The motivation of the paper is to discuss and analyze coronary artery disease in the field of dynamics. Firstly, the mathematic model of coronary artery systems is formulated and the properties of this model are illustrated by bifurcation diagram, information entropy analysis, phase plane trajectory, and Poincaré section. With regard to the uncertainties of coronary artery systems, the disturbance observer technique is adopted. Meanwhile, the smooth second-order sliding mode controller is designed to suppress the chaos phenomenon. In light of the combination of the controller and observer, the stability of such a closed-loop system is proven in the sense of Lyapunov. Finally, some numerical simulations demonstrate the feasibility and validity of such design.

Numer Methods Biomed Eng

Experimental and numerical investigation of the stenosed coronary artery taken from the clinical setting and modeled in terms of hemodynamics

Sonmez,

Karagoz,

Yildirim

et al. 2023

The study was carried out to investigate the effect of the artery with different pulse values and stenosis rates on the pressure drop, the peristaltic pump outlet pressure, fractional flow reserve (FFR) and most importantly the amount of power consumed by the peristaltic pump. For this purpose, images taken from the clinical environment were produced as models (10 mm inlet diameter) with 0% and 70% percent areal stenosis rates (PSR) on a three‐dimensional (3D) printer. In the experimental system, pure water was used as the fluid at 54, 84, 114, 132, and 168 bpm pulse values. In addition, computational fluid dynamics (CFD) analyzes of the test region were performed using experimental boundary conditions with the help of ANSYS‐Fluent software. The findings showed that as PSR increases in the arteries, the pressure drop in the stenosis region increases and this amount increases dramatically with increasing effort. An increase of approximately 40% was observed in the pump outlet pressure value from 54 bpm to 168 bpm in the PSR 0% model and 51% increase in the PSR 70% model. It has been observed that the pump does more work to overcome the increased pressure difference due to increased pulse rate and PSR. With the effect of contraction, the power consumption of the pump increased from 9.2% for 54 bpm to 13.8% for 168 bpm. In both models, the Wall Shear Stress (WSS) increased significantly. WSS increased abruptly in the stenosis and arcuate regions, while sudden decreases were observed in the flow separation region.