Management of corneal neurotrophic ulcers with Cacicol®-RGTA (ReGeneraTing Agent): a case series

Salazar-Quiñones, L.; Molero-Senosiain, Mercedes; Aguilar-Munoa, Soledad; Gegúndez-Fernández, J.A.; Díaz-Valle, D.; Muñoz-Hernández, A.M.; Benítez-del-Castillo, J.M.

doi:10.1016/j.oftale.2020.04.005

Cited by 3 publications

(3 citation statements)

References 24 publications

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“…Regenerating agent (RGTA, Cacicol) is a matrix containing large polymers mimicking heparan sulfates. In a retrospective study corneal ulcers, which were unresponsive to conventional therapy, healed after usage of Cacicol in 9 cases out of 11 [ 16 ]. A recombinant nerve growth factor (Cenegermin, Oxervate) has the effect on epithelial proliferation and improved sensory functions of the cornea for patients with neurotrophic keratitis [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Neurotrophic Keratitis Due to Congenital Corneal Anesthesia with Deafness, Hypotonia, Intellectual Disability, Face Abnormality and Metabolic Disorder: A New Syndrome?

et al. 2022

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Neurotrophic keratitis is a rare degenerative disease of the cornea that can lead to corneal ulceration, scarring, and significant visual impairment. It most commonly occurs in adults and is rarely diagnosed in children. Congenital corneal anesthesia is an extremely rare condition that requires appropriate ophthalmologists’ attention in making diagnosis and treatment decisions. This condition usually presents in infancy or early childhood and is characterized by rare blinking rate, decreased tearing or a corneal ulcer that is unresponsive to treatment. In this case report, we describe a patient with multiple systemic and neurological disorders who presented to the ophthalmology department due to corneal erosion unresponsive to treatment. Brain magnetic resonance imaging confirmed bilateral trigeminal hypoplasia and the diagnosis of neurotrophic keratopathy due to bilateral congenital corneal anesthesia was made. The discrepancy between clinical signs and symptoms or treatment non-response in cases of corneal erosions should alert the ophthalmologists to suspect trigeminal dysfunction. MRI is the gold standard to confirm congenital corneal anesthesia and to differentiate from other possible neurotrophic keratitis causes.

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Section: Discussionmentioning

confidence: 99%

Neurotrophic Keratitis Due to Congenital Corneal Anesthesia with Deafness, Hypotonia, Intellectual Disability, Face Abnormality and Metabolic Disorder: A New Syndrome?

et al. 2022

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“…The NGF-loaded BPC can release NGF up to two months in vitro but further in vivo studies of NK experimental models are required to determine its efficacy in treating this blinding corneal condition. RGTA has also been successfully tested in the treatment of NK by providing binding sites for growth factors to promote healing [105][106][107][108] . In this thesis, we have shown that RGTA does not improve the already rapid epithelial closure following laser ablation of the anterior cornea in healthy rabbits.…”

Section: Discussionmentioning

confidence: 99%

Advanced surgeries, medicines and materials for corneal regeneration

Xeroudaki

2022

Linköping University Medical Dissertations

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“…The use of topical regenerating agent (RGTA; Cacicol20®; OTR3, Paris, France) has been described. [ 47 48 49 50 51 ] Complete healing in 73% of cases (8/11) with NK after a mean period of 8.7 weeks was seen in one study. [ 48 ] However, Arvola et al .…”

Section: Neurotrophic Keratopathymentioning

confidence: 99%

Neurotization of the human cornea – A comprehensive review and an interim report

Ramappa

Rathi

Bothra

et al. 2022

Indian Journal of Ophthalmology

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We present a comprehensive review of existing literature on surgical corneal neurotization (SCN) as a treatment modality for neurotrophic keratopathy (NK) with an interim report of seven cases where SCN was performed using the indirect approach and followed up till 18 months postoperatively to look for improvement in ocular surface, corneal sensations, and nerve regeneration by using in vivo confocal microscopy (IVCM). A literature search was performed for publications with keywords “corneal nerves,” “neurotization,” “esthesiometry,” “corneal anesthesia,” and “neurotrophic keratopathy.” All literature available till December 31, 2020 was reviewed and included to describe NK and its management options, particularly SCN. NK is associated with absent or reduced corneal sensations and is managed using a step-ladder algorithm ranging from medical management for symptomatic relief to surgical corneal neurotization. Both direct and indirect approaches of SCN have a favorable outcome with reduced surgical morbidity in the indirect approach using sural nerve graft. Post neurotization, corneal sensation recovery may take up to 3–6 months, while nerve regeneration on confocal microscopy can take as long as 6 months–1 year.

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Management of corneal neurotrophic ulcers with Cacicol®-RGTA (ReGeneraTing Agent): a case series

Cited by 3 publications

References 24 publications

Neurotrophic Keratitis Due to Congenital Corneal Anesthesia with Deafness, Hypotonia, Intellectual Disability, Face Abnormality and Metabolic Disorder: A New Syndrome?

Neurotrophic Keratitis Due to Congenital Corneal Anesthesia with Deafness, Hypotonia, Intellectual Disability, Face Abnormality and Metabolic Disorder: A New Syndrome?

Advanced surgeries, medicines and materials for corneal regeneration

Neurotization of the human cornea – A comprehensive review and an interim report

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