Congenital nasolacrimal duct obstruction (CNLDO) is the most common cause of persistent lacrimation with secretion in the eye, in children. Symptoms appear in approx. 5% of neonates and infants. Most often it is caused by presence of an abnormal membrane in the distal segment of the nasolacrimal duct (Hasner' s valve), hence usually we are dealing with congenital obstruction of the nasolacrimal duct. Much less often, difficulties in the outflow of tears in children is caused by stenosis of the nasolacrimal duct or, for example, absence of lacrimal points and ducts. An increased risk of tear duct obstruction occurs in children with Down syndrome, hemifacial hypoplasia, midfacial anomalies, craniosynostoses, Goldenhar syndrome, and cleft syndromes. Obstruction of the lacrimal duct and the associated blockage in the outflow of tears causes several symptoms, including retention of tears, wet and clustered eyelashes, presence of secretion in the conjunctival sac (initially mucous, then mucopurulent or purulent) accumulating on the edges of eyelids and on eyelashes, and retention of pathological content in the lacrimal sac. Those symptoms develop in the first month of life. In 30% of children with congenital nasolacrimal duct obstruction, problems with outflow of tears occur bilaterally. In these cases, complex obstruction in the upper part of the nasolacrimal ducts (lacrimal ducts, lacrimal sac, upper part of the nasolacrimal duct) is more common, rather than obstruction at Hasner's valve level. Main complications of CNLDO are: dacryocystitis, inflammation of orbital soft tissue, upper respiratory tract infection, more frequent anisometropia and amblyopia on the side of obstructed lacrimal ducts. The diagnosis of CNLDO is based mostly on characteristic clinical symptoms.