Management of colorectal cancers

Lewis, Ruth; Flynn, Andrea; Dean, M.; Melville, A; Eastwood, Alison; Booth, Andrea

doi:10.1136/qshc.2004.011817

Cited by 1 publication

(1 citation statement)

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“…Colorectal cancer is thought to result from a complex interaction between inherited susceptibility and environmental factors, as indicated by genetics and experimental and epidemicological studies [3][4][5]. Approximately 75% of patients have neither a clear family history nor any known predisposing condition [6]. According to observational studies that had been performed, development of CRC may be related to environmental factors such as high calorie intake, high consumption of red meat (especially if overcooked), high consumption of saturated fat, low consumption of fruit, vegetables and fibre, high alcohol intake, obesity, cigarette smoking, and a sedentary lifestyle [7].…”

Section: Introductionmentioning

confidence: 99%

Plasma Concentrations of Some Trace Element and Heavy Metals in Patients with Metastatic Colon Cancer

Özgür¹,

Demır²,

Doğan³

et al. 2013

JCT

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Purpose: It is well known that trace elements and heavy metals play a significant role in human health and disease. These elements play an important role in different metabolic pathways of cells and tissues. Trace element deficiency or excess is implicated in the development or progression of some cancers. We present a study which investigates serum/ plasma levels of trace-heavy elements in metastatic colon cancer patients and healthy subjects. Methods: Blood samples were collected from 29 healthy subjects and 40 patients with metastatic colon cancer in Oncology Department of Medical School of Yuzuncu Yil University. In both groups, the serum levels of copper (Cu), magnesium (Mg), lead (Pb), chromium (Cr), zinc (Zn) selenium (Se), manganese (Mn), and cadmium (Cd) were determined. Results: Higher levels of Cu, Mg, Pb, Cr, Zn, Mn and Cd were seen in patients with metastatic colon cancer compared to healthy subjects and these findings were statistically significant (p < 0.05). Se levels were noted to be lower in patients with colon cancer in comparison to healthy subjects and this finding was also statistically significant (p < 0.05). Conclusions: According to our findings there was significant diffence in trace elements and heavy metals levels between healthy subjects and metastatic colon cancer patients. Therefore heavy metal and trace elements may have prognostic significance in complex disorders including colon cancer. However, further comprehensive studies are needed in order to advance our understanding of the relationship between heavy metal and trace elements and their role in cancers.

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Section: Introductionmentioning

confidence: 99%