Management of Clear Cell Odontogenic Carcinoma: A Case Report

Memtsa, Pinelopi Theopisti; Papadopoulou, Aikaterini; Vachtsevanos, Konstantinos; Tzitzikas, Ioannis

doi:10.14740/jmc3080w

Cited by 4 publications

(4 citation statements)

References 6 publications

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“…However, this may be more reflective of the biology of their disease than treatments associated with worse outcomes, as those with distant metastases also had worse survival compared with those with only localised disease. As a result, chemotherapy is largely regarded as a palliative measure 15. There are no publications involving management with immunotherapy or targeted therapies.…”

Section: Discussionmentioning

confidence: 99%

Case of metastatic clear cell odontogenic carcinoma with response to chemoimmunotherapy

Robertson,

Robbins,

2024

BMJ Case Rep

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Our patient initially presented with 6 months of left jaw pain and gingival bleeding, leading to the discovery of a radiolucent left maxillary mass on dental evaluation. A biopsy confirmed clear cell odontogenic carcinoma, and the patient was treated with definitive surgery and radiation for localised disease. Unfortunately, the patient was found to have pulmonary metastases 3 months after initial management and was subsequently treated with a combination of cytotoxic chemotherapy and immunotherapy with a partial response. To our knowledge, this is the first case demonstrating the successful use of chemoimmunotherapy in metastatic clear cell odontogenic carcinoma.

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Section: Discussionmentioning

confidence: 99%

Case of metastatic clear cell odontogenic carcinoma with response to chemoimmunotherapy

Robertson,

Robbins,

2024

BMJ Case Rep

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“…The clear cell variant of mucoepidermoid carcinoma (MEC) may complicate the differential diagnosis, but MEC exhibits at least focally solid nests of tumour cells consisting of a mixture of epidermoid, mucous and intermediate cells 11 . Moreover, most MEC are positive for CK7, which is negative in CCOC akin to squamous cell carcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, up to 70% of cases of MEC demonstrate a specific chromosomal translocation t (11;19) (q21;p13), which creates the MECT1‐MAML2 fusion transcript. This could be used to establish the diagnosis 11 …”

Section: Discussionmentioning

confidence: 99%

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Biphasic clear cell odontogenic carcinoma: An aggressive metastatic neoplasm

et al. 2021

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Introduction The recent classification of odontogenic tumours includes the entities clear cell odontogenic carcinoma (CCOC) and clear cell ameloblastoma (CCAM) under the unifying name CCOC. The lack of ameloblastic differentiation in many cases of CCOC, its more aggressive behaviour and unique molecular profile suggest a distinct entity which merits its own standing in the classification of odontogenic carcinomas. Case report A 53‐year‐old male presented with excessive hyperplastic tissue in the anterior maxilla. Microscopic examination disclosed a biphasic clear cell neoplasm with nests of polygonal clear cells, surrounded by intensely eosinophilic flattened cells. The tumour cells were immunoreactive for MNF 116, CK 14, CK 19, CK 5 and EMA. The proliferation index, Ki67, was low and its expression, similar to the basal‐cell‐specific cytokeratins (CK 14 and CK5), was confined to the peripheral cells. Molecular studies confirmed EWSR1 gene rearrangements. An anterior maxillectomy was performed, supplemented with radiotherapy. Three years after resection, multiple metastatic bodies were detected in the lung and the patient passed away 1 year later. Conclusion This case further supports the notion that CCOC with biphasic histomorphology appears to have a high mortality rate, and it may be wise to treat and monitor these patients more aggressively.

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