Management of Chronic Hepatitis B in Pregnancy: A Consensus Report of the Study Group for Viral Hepatitis of the Turkish Society of Clinical Microbiology and Infectious Diseases

Aygen, Bilgehan; Keten, Derya; Akalın, Halis; Aşan, Ali; Bozdag, Heval; Çağır, Ünal; Demirtürk, Neşe; Eraksoy, Haluk; Erbay, Afet; Gürbüz, Yunus; İnan, Dilara; Koçulu, Safiye; Öncü, Serkan; Ozkaya, Deniz; Saltoğlu, Neşe; Sayan, Murat; Süer, Kaya; Şener, Alper; Koruk, Süda Tekin; Tuna, Nazan; Yazıcı, Saadet

doi:10.5152/kd.2013.14

Cited by 5 publications

(3 citation statements)

References 32 publications

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“…Early membrane rupture, spontaneous abortions and contact with the mother's vaginal secretions increase the vertical transmission risk of HBV. HBV DNA levels in maternal serum are the most important indicator and risk factor for transmission [9]. Many problems arise with the increasing number of refugees both in our country and around the world.…”

Section: Discussionmentioning

confidence: 99%

Analysis of HbsAg positivity rate before and after vaccination in Turkish and Syrian refugee pregnant women

İnci

Yildirim

Seçkin

et al. 2017

J Infect Dev Ctries

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Introduction: In this study, we aimed to investigate the vaccination rate in Turkish and Syrian pregnant women who gave birth in our hospital, research the difference before and after vaccination, compare these results with other studies conducted in our country and be beneficial to physicians in the follow up of this patient group, who we started to encounter rather frequently in recent months. Methodology: The data of pregnant women who were referred to Kanuni Sultan Suleyman Education and Research Hospital between January and December 2015 were retrospectively investigated. Results: A total of 4186 pregnant women, 2158 of Syrian and 2028 of Turkish, were included in this study. The rate of hepatitis B surface antigen (HbsAg) positivity was 1.4% among all pregnant women. This value was found to be 1.8% among Turkish women and 1.1% among Syrian women. Evaluation of age distribution showed that there were 30 Turkish pregnant women born after the inclusion of vaccine into the program (1998 and later), of which one was HbsAg positive. While out of 958 Syrian women born in 1991 and later, 10 were HbsAg positive. Conclusion: This study shows that the surveillance of hepatitis among pregnant women, including refugees and locals is important to protect fetus and guide in planning of preventive measures such as administration of vaccines and immunoglobulins. Timely prevention may decrease morbidity and mortality caused by hepatitis viruses.

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Section: Discussionmentioning

confidence: 99%

Analysis of HbsAg positivity rate before and after vaccination in Turkish and Syrian refugee pregnant women

İnci

Yildirim

Seçkin

et al. 2017

J Infect Dev Ctries

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“…Because there were no previous test results for hepatitis B in pregnant patients, we could not comment on this issue. It is recommended that all pregnant women be screened for HBV infection and chronic hepatitis infections should be closely observed for mother and baby's health (17,18).…”

Section: Discussionmentioning

confidence: 99%

Causes of Acute Exacerbation of Chronic Hepatitis B Infection: A Report of Case Series

C¹,

Tülek²,

Aktepe³

et al. 2015

vhd

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ÖZETObjective: In the course of chronic hepatitis B infection, acute exacerbations characterized by high ALT and HBV DNA levels may occur. Sometimes icterus and hepatic decompensation may develop in severe cases. In this study, we evaluated characteristics of patients who were diagnosed as having acute exacerbation of chronic hepatitis B and the reasons that lead to exacerbation. Materials and Methods:Patients with acute exacerbation of chronic hepatitis B followed up in a training and research hospital clinic between 2010 and 2014, were retrospectively evaluated. Acute exacerbation was diagnosed by detection of 5-fold increase or more than twice of the previous values in ALT levels and elevation of HBV DNA (>10 5 I.U) in patients with chronic hepatitis. Age, gender, known duration of hepatitis B infection, medication, HBeAg positivity and anti-HBc IgM, ALT, AST, albumin, prothrombin time and HBV DNA levels of patients were recorded.

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“…Many international organizations (Advisory Committee on Immunization Practices, World Health Organization) recommend that all pregnant women be tested for hepatitis B surface antigen (HBsAg). Even though vaccine + immune globin has been administered to the infant against HBV for many years, perinatal transmission occurs in at least in 10% of children born to mothers with high levels of viremia [ 5 , 6 ]. For this reason, oral antiviral use in the last trimester has been recommended in some pregnant women in recent years [ 7 , 8 ].…”

mentioning

confidence: 99%

Prevalence of HBsAg Seropositivity during Pregnancy and Evaluation of Vaccination Programs: A Multicenter Study in Turkey

Bilman

Tosun

Yıldız

et al. 2020

North Clin Istanbul

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OBJECTIVE: Hepatitis B virus (HBV) infection remains a global public health problem. Among its modes of transmission, vertical transmission from mother to child during pregnancy is exceedingly important. This study investigated seropositivity for hepatitis B surface antigen (HBsAg) among pregnant women aged 16–49 years and their pregnancy outcomes in several health institutions (university and state hospitals, family health centers) from seven cities in Turkey. METHODS: An Excel form was sent to the sites participating in the study, and the total number of pregnant women who were tested for HBsAg between 2010 and 2017, HBsAg positivity rates, and the ages of HBsAg-positive pregnant women was collected retrospectively. Serum samples were obtained from 204,865 pregnant women from four regions between 2010 and 2017, including 107,463 from Black Sea, 2306 from Marmara, 48,339 from East Anatolia, and 46,757 from Aegean. HBsAg levels were determined on automated devices using chemiluminescence. RESULTS: In the study, the data of 204,865 pregnant women from seven different provinces (Afyonkarahisar, Erzurum, Istanbul, Izmir, Manisa, Mus, and Rize) in different geographical regions were accessed, and HBsAg positivity was found in 2343 pregnant women (1.14%). The highest HBsAg seroprevalence was found in women who were older 26–40 years/1977–1991 birth year range on average. In the data of the present study, the number of pregnant women with HBsAg positivity among pregnant women born after the initiation of the national vaccination program and catch-up vaccination program is only 124 and constitutes 5.3% of all HBsAg-positive pregnant women CONCLUSION: In this study, it has been found that HBsAg positivity in pregnant women has been decreasing in Turkey and that it is significantly lower, especially in those born after the initiation of the national vaccination program. Continuation of national neonatal HBV vaccination with high compliance is very important.

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Management of Chronic Hepatitis B in Pregnancy: A Consensus Report of the Study Group for Viral Hepatitis of the Turkish Society of Clinical Microbiology and Infectious Diseases

Cited by 5 publications

References 32 publications

Analysis of HbsAg positivity rate before and after vaccination in Turkish and Syrian refugee pregnant women

Analysis of HbsAg positivity rate before and after vaccination in Turkish and Syrian refugee pregnant women

Causes of Acute Exacerbation of Chronic Hepatitis B Infection: A Report of Case Series

Prevalence of HBsAg Seropositivity during Pregnancy and Evaluation of Vaccination Programs: A Multicenter Study in Turkey

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