Management of chronic cough

Pavord, Ian D.; Chung, Kian Fan

doi:10.1016/s0140-6736(08)60596-6

Cited by 151 publications

(94 citation statements)

References 101 publications

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“…[3][4][5][6] Patients with unexplained chronic cough (UCC) experience significant impairments in quality of life. They endure a chronic cough that persists, often for many months or years, despite systematic investigation and treatment of known causes.…”

Section: Summary Of Recommendations and Suggestionsmentioning

confidence: 99%

“…These processes are detailed in the CHEST chronic cough guideline, 2 as well as in other cough reviews. 4,5 The completeness of this assessment and treatment approach according to the five areas of intervention fidelity (study design, training of providers, delivery of treatment, receipt, and enactment of treatment) 41 is recognized as an important paradigm in the determination of UCC. Although the studies reviewed in this assessment showed fair to good adherence to intervention fidelity, there are clearly opportunities to provide better documentation of the assessment process in published reports.…”

Section: Diagnosismentioning

confidence: 99%

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Treatment of Unexplained Chronic Cough

Gibson

Wang²,

McGarvey

et al. 2016

Chest

283

129

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Section: Summary Of Recommendations and Suggestionsmentioning

confidence: 99%

Section: Diagnosismentioning

confidence: 99%

Treatment of Unexplained Chronic Cough

Gibson

Wang²,

McGarvey

et al. 2016

Chest

283

129

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“…Unless this distinction is made, steroid therapy may be continued without evidence of response, with consequent risk of adverse events. A short-term diagnostic trial of oral corticosteroids has been recommended [36] on the basis that, in some patients, inhaled steroid therapy appears to be inadequate and high-dose prednisolone is required to control cough [37]. Other evidence, such as the effect of a tyrosine kinase inhibitor controlling not only eosinophilia but also cough in hypereosinophilic syndrome characterised by aberrant tyrosine kinase activity, is consistent with this view [37].…”

Section: The Cough Reflex Questionmentioning

confidence: 97%

Expert opinion on the cough hypersensitivity syndrome in respiratory medicine

et al. 2014

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In 2011, a European Respiratory Society Task Force embarked on a process to determine the position and clinical relevance of the cough hypersensitivity syndrome, a disorder characterised by troublesome coughing often triggered by low levels of thermal, mechanical or chemical exposure, in the management of patients with chronic cough. A 21-component questionnaire was developed by an iterative process supported by a literature review. 44 key opinion leaders in respiratory medicine were selected and interviewed as to their opinions.There was a high degree of unanimity in the responses obtained, with all opinion leaders supporting the concept of cough hypersensitivity as a clinically useful paradigm. The classic stratification of cough into asthmatic, rhinitic and reflux-related phenotypes was supported. Significant disparity of opinion was seen in the response to two questions concerning the therapy of chronic cough. First, the role of acid suppression in reflux cough was questioned. Secondly, the opinion leaders were split as to whether a trial of oral steroids was indicated to establish a diagnosis of eosinophilic cough.The cough hypersensitivity syndrome was clearly endorsed by the opinion leaders as a valid and useful concept. They considered that support of patients with chronic cough was inadequate and the Task Force recommends that further work is urgently required in this neglected area. @ERSpublications Cough hypersensitivity syndrome was clearly endorsed by opinion leaders as a valid and useful concept

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“…Chronic cough is a difficult clinical problem, partly because there is an absence of well-validated means to assess cough [1,2]. We have previously reported that the semi-automated computerised Leicester Cough Monitor detects cough accurately over 6 h and that cough frequency is increased in patients with chronic cough compared to controls [3,4].…”

Section: To the Editormentioning

confidence: 99%