Management of choroidal metastasis using external beam radiotherapy: a retrospective study and review of the literature

Youbi, Z.; Enachescu, C.; Caraivan, I.; Zineb, Bennani; Majdouline, Khounigere; Léa, Kotzki; Pierre-Marie, P.; Pierre, S. Marie; Yossi, Sena

doi:10.20517/2394-4722.2017.07

Cited by 4 publications

(3 citation statements)

References 25 publications

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“…Earlier case series reported a 12%-rate of toxicity with conventional EBRT [9], but a recent case series reported no late toxicity and no grade-2-3 acute toxicity with this approach [10]. This difference is perhaps due to a shorter follow-up period in the later publication although the advancement and refinement of radiotherapy techniques may have been an important contributory factor as well.…”

Section: Discussionmentioning

confidence: 96%

Bilateral Choroidal Metastases In Triple-Negative Breast Cancer: Radiotherapy And Eribulin For Vision Preservation And Prolong Survival

Hasbullah

Zulkiffli²,

Dicken

2021

Indonesian Journal of Cancer

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Introduction: Choroidal metastases are infrequent in breast cancer, but if they present, they usually signify the disseminated disease and poor prognosis. The challenges in treating choroidal metastases are not only to prolong survival but also to preserve vision, improving the quality of life. Case Presentation: Our patient was firstly diagnosed with stage-three triple-negative breast cancer at the age of 32 years. She had surgery, adjuvant chemotherapy with anthracycline regime, as well as adjuvant radiotherapy. Her disease firstly recurred two years later with pleural effusion, but it was controlled with six cycles of docetaxel. She was in remission until ten years later when she presented with a worsening dry cough and progressive blurring of vision in both eyes. CT restaging showed multiple sub-centimeter bilateral lung nodules, singular pleural metastases, and multiple bone metastases. Choroidal metastases were also confirmed with the ophthalmological assessment which includes CT of the orbit. She received short-course palliative radiotherapy followed immediately by eribulin. Then, she started monthly bisphosphonates. She was able to read again four months after radiotherapy, and her vision remains normal to date. The latest PET scans showed no FDG avid disease in the lungs with pleural metastases significantly reduced in size. Bone metastases remain stable and asymptomatic. It has been nearly four years since the diagnosis of choroidal metastases. She is still on eribulin at an adjusted dose and interval. She remains asymptomatic from her bone, lung, and choroidal metastases. Conclusions: Short-course radiotherapy to the orbit, followed by continuous administration of eribulin, can lead to prolonged survival with a good quality of life in triple-negative breast cancer with choroidal metastases

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Section: Discussionmentioning

confidence: 96%

Bilateral Choroidal Metastases In Triple-Negative Breast Cancer: Radiotherapy And Eribulin For Vision Preservation And Prolong Survival

Hasbullah

Zulkiffli²,

Dicken

2021

Indonesian Journal of Cancer

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“…The dose fractionation schedules of RT markedly varied. Although many schedules were reported in retrospective series, most studies adopted schedules of 30-40 Gy in 10-20 fractions [5,6,[8][9][10]14,16,[18][19][20][21][22][23][24][25][26][27][28][29]. In prospective studies, Wiegel et al [7] employed a schedule of 40 Gy in 20 fractions, while Bellmann et al [30] adopted schedules of stereotactic RT with 12-20 Gy in 1 fraction or 30 Gy in 10 fractions.…”

Section: Findings Of Recent Studies On Radiation Therapy For Choroida...mentioning

confidence: 99%

Clinical Outcomes of Radiation Therapy for Choroidal Metastases and A Literature Review

NIWA,

TOMITA,

MIYAKAWA

et al. 2022

Kurume Med. J.

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Ocular metastasis is the most common intraocular tumor but choroidal metastasis (CM) is rare. Bloch and Gartner [1] performed post-mortem examinations on the eye and orbit of 230 cancer patients and detected metastases in 28 eyes, with an overall incidence of 12%. Nelson et al. [2] also found intraocular metastases in 9% of 716 eyes. On the other hand, the incidence of clinically symptomatic cases was reported to

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“…No visual degradation was found with use of EBRT. 25 Despite its widespread use, treatment is not without local ocular side effects including cataract formation, radiation retinopathy, radiation optic neuropathy, exposure keratopathy, and iris neovascularization amongst others. 26,27 Unfortunately, multiple treatment sessions are required as the total dose needed to kill a tumor is too toxic to be given in one session, which may prove problematic given the majority of patients with advanced disease states.…”

Section: Differential Diagnosesmentioning

confidence: 99%

Background, Treatment and Management in a Patient with Bilateral Choroidal Metastases

Moore¹,

Yeh²,

Ferrucci

2020

CRO (Clinical &Amp; Refractive Optometry) Journal

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Choroidal metastasis refers to a tumor that stems from a primary malignancy elsewhere in the body and spreads to the choroid through blood circulation. While once considered rare, choroidal metastasis is now considered the most common adult intraocular malignancy. Due to advances in treatments, extended life expectancy in those diagnosed with cancer has increased the prevalence of choroidal metastasis. Along with ultrasound and fluorescein angiography, newer ocular imaging techniques are clinically accessible to aid in the diagnosis and management of the tumors. Different treatment strategies are also available to best suit the patient’s systemic and ocular states. This case report reviews the background, treatment and management of a patient with choroidal metastases. CE Notification: This article is available as a COPE accredited CE course. You may take this course for 1-hour credit. Read the article and take the qualifying test to earn your credit. Click here to Enroll (https://www.crojournal.com) Please check COPE course expiry dates prior to enrollment. The COPE course test must be taken before the course expiry date.

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Management of choroidal metastasis using external beam radiotherapy: a retrospective study and review of the literature

Cited by 4 publications

References 25 publications

Bilateral Choroidal Metastases In Triple-Negative Breast Cancer: Radiotherapy And Eribulin For Vision Preservation And Prolong Survival

Bilateral Choroidal Metastases In Triple-Negative Breast Cancer: Radiotherapy And Eribulin For Vision Preservation And Prolong Survival

Clinical Outcomes of Radiation Therapy for Choroidal Metastases and A Literature Review

Background, Treatment and Management in a Patient with Bilateral Choroidal Metastases

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