Management of cataract in Werner syndrome

A 36-year-old male presented with young-onset diabetes and advanced peripheral vascular disease. He had a history of bilateral juvenile cataracts and premature aged appearance. Closer scrutiny unraveled multiple endocrine and nonendocrine abnormalities. Genetic studies revealed a novel pathogenic variant (homozygous c.3233+2T>c) confirming and expanding the mutation spectrum of Werner syndrome. This report highlights the need for precise diagnosis, which has important implications for prognosis and genetic counseling.

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Werner Syndrome

Monteiro

Pavithran

Nampoothiri

et al. 2021

Journal of Diabetology

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Management of cataract in Werner syndrome

Abstract: Werner syndrome (WS) is a rare progressive disorder. It is characterized by the appearance of unusually accelerated aging (progeria) including bilateral senile cataract. Here, we report a successful management of hypermature cataract in WS.

Cited by 1 publication

References 6 publications

Werner Syndrome

Werner Syndrome

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