Management of cardiovascular disease risk in chronic inflammatory disorders

Kaplan, Mariana J.

doi:10.1038/nrrheum.2009.29

Cited by 62 publications

(58 citation statements)

References 136 publications

(125 reference statements)

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“…The degree of inflammation, as assessed by high sensitivity CRP, cytokines or antineutrophil cytoplasmic antibodies (ANCA) also predicts cardiovascular mortality and morbidity [1]. These observations suggest that arterial stiffness and cardiovascular mortality and morbidity should be increased in subjects with systemic inflammation [24][25][26][27][28][29][30][31][32][33][34]. However, some data concerning this are conflicting [35].…”

Section: Introductionmentioning

confidence: 99%

Arterial Distensibility in Chronic Inflammatory Rheumatic Disorders

Yıldız¹

2010

TOCMJ

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Abstract:The pulse wave velocity (PWV), as an indicator of arterial distensibility, may play an important role in the stratification of patients based on the cardiovascular risk. PWV inversely correlates with arterial distensibility and relative arterial compliance. Decreased arterial distensibility alters arterial blood pressure and flow dynamics, and disturbes coronary perfusion. Systemic immune and inflammatory diseases, such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are associated with increased morbidity and mortality, predominantly due to adverse cardiovascular events. Systemic inflammation in these disorders may alter arterial compliance and arterial distensibility and, through this effect, lead to accelerated atherosclerosis. We have demonstrated an increase in the carotid-femoral (aortic) PWV that is a technique in which large artery elasticity is assessed from analysis of the peripheral arterial waveform, in patients with chronic inflammatory conditions such as RA, SLE, familial Mediterranean fever (FMF), Wegener's granulomatosis (WG), sarcoidosis, psoriasis and psoriatic arthritis except Behçet's disease (BD). In this review, the issue of arterial stiffness in RA, SLE, as well as WG, psoriasis, FMF, BD, sarcoidosis, systemic sclerosis (SS) and Takayasu's arteritis (TA) is overviewed.

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Section: Introductionmentioning

confidence: 99%

Arterial Distensibility in Chronic Inflammatory Rheumatic Disorders

Yıldız¹

2010

TOCMJ

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“…Over the past decade, it has become evident that upregulation of inflammation and autoimmune aggression in certain systemic disorders such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) may substantially accelerate atherogenesis and increase the risk of vascular events [10][11][12]. Basic and clinical research studies in this *Address correspondence to this author at the Boğaziçi University, Department of Molecular Biology and Genetics, 34342 Bebek/Istanbul, Turkey; Tel: +90(212) 359-77-84; Fax: +90 (212) 287-2468; E-mail: sahru.yuksel@boun.edu.tr field have led to the emergence of a new biomedical discipline, vascular rheumatology [13], which aims to clarify pathophysiology of rheumatic diseases and co-morbidities and to propose recommendations for primary and secondary prevention of vascular events in the general population.…”

Section: Introductionmentioning

confidence: 99%

Familial Mediterranean Fever as an Emerging Clinical Model of Atherogenesis Associated with Low-Grade Inflammation

Yüksel¹,

Ayvazyan²,

Gasparyan³

2010

TOCMJ

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Numerous inflammatory and innate immune pathways are involved in atherogenesis. Elaboration of clinical models of inflammation-induced atherogenesis may further advance our knowledge of multiple inflammatory pathways implicated in atherogenesis and provide a useful tool for cardiovascular prevention. Familial Mediterranean fever (FMF) is a chronic inflammatory disorder with profiles of inflammatory markers close to that seen in the general population. In a few recent studies, it has been shown that endothelial dysfunction, increased atherosclerotic burden and activation of platelets accompany attack-free periods of FMF. Colchicine is proved to be useful in suppression of inflammation in FMF. Preliminary basic and clinical studies suggest that this relatively safe drug may be useful for cardiovascular protection in patients with FMF and in the general population. Multinational prospective studies are warranted to further elaborate clinical model of inflammation-induced atherosclerosis associated with FMF.

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“…31 Several studies have revealed that atherogenesis is highly accelerated by upregulated inflammation and autoimmune attacks in highgrade inflammatory disorders such as rheumatoid arthritis and SLE. 32,33 Relationship between atherogenesis and low-grade inflammatory conditions such as ankylosing spondylitis and FMF has been relatively recently suggested and studies about this relationship build up over time. [34][35][36] However, studies investigating carotid atherosclerosis in FMF found less aggressive course of atherogenesis than atherogenesis in highgrade inflammatory disorders.…”

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confidence: 99%

Glutathione-S-Transferase Variants are not Associated With Increased Carotid Intima-Media Thickness in Turkish Familial Mediterranean Fever Patients

Gürbüz

Bağcı²,

Hüzmelí

et al. 2016

Arch Rheumatol

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Objectives: This study aims to evaluate the carotid intima-media thickness (CIMT) in patients diagnosed with familial Mediterranean fever (FMF) and investigate whether there is a relationship between glutathione-S-transferase (GST) gene polymorphisms and CIMT. Patients and methods: Sixty FMF patients (17 males, 43 females; mean age: 31.43±11.36 years; range 18 to 45 years) and 60 healthy controls (22 males, 38 females; mean age: 29.8±5.82 years; range 18 to 40 years) were enrolled in this study. Polymerase chain reaction-restriction fragment length polymorphism methods were carried out to assess GST polymorphisms. CIMT was measured by carotid ultrasonography. Biochemical parameters were also evaluated using biochemical methods. Results: Right and left CIMT of FMF patients were statistically significantly higher than that of control group (CIMT right p=0.001 and CIMT left: p=0.033). There was no significant association in terms of GST polymorphisms between FMF and control groups. No significant association was observed between GST polymorphisms and CIMT. Low density lipoprotein, erythrocyte sedimentation rate, and fibrinogen levels were significantly higher in the patient group (p<0.05). The difference between groups was not significant in terms of other biochemical parameters (p>0.05). Conclusion: Although no significant association was observed between GST polymorphisms and CIMT in FMF patients and controls, CIMT was statistically significantly higher in FMF patients compared to controls.

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Management of cardiovascular disease risk in chronic inflammatory disorders

Cited by 62 publications

References 136 publications

Arterial Distensibility in Chronic Inflammatory Rheumatic Disorders

Arterial Distensibility in Chronic Inflammatory Rheumatic Disorders

Familial Mediterranean Fever as an Emerging Clinical Model of Atherogenesis Associated with Low-Grade Inflammation

Glutathione-S-Transferase Variants are not Associated With Increased Carotid Intima-Media Thickness in Turkish Familial Mediterranean Fever Patients

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