Management of Cardiorenal Metabolic Syndrome in Diabetes Mellitus: A Phytotherapeutic Perspective

Song, Min-Young; Davies, Neal M.; Roufogalis, Basil D.; Huang, Tom

doi:10.1155/2014/313718

Cited by 13 publications

(12 citation statements)

References 119 publications

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“…DM causes most of its morbidity and mortality through the damage or failure of different organs and tissues, including arteries, heart, kidneys, nerves, and retina . The prevention of DM involves glycemic monitoring, healthy eating, and physical activity practicing.…”

Section: Dm and Disrupted Metal Balancementioning

confidence: 99%

Dissecting copper homeostasis in diabetes mellitus

2017

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Diabetes Mellitus (DM) is characterized by elevated blood glucose levels (hyperglycemia). It can occur due to impaired secretion or action of the hormone insulin, which is produced by pancreatic beta-cells to promote the entry of glucose into the cells. It is known that hyperglycemia has an important role in the production of reactive oxygen species in all types of DM and that an imbalance of transition metal as Cu and Fe plays a pivotal role in stimulating the oxidative stress. Different levels of some transition metals, as Cu, Fe, Mn, and Zn has been reported comparing diabetic animal models with the control group. An increased Cu status is also described in diabetic patients. Homeostasis of Cu depends on distinct proteins, where Cu(I)-ATPases are important transmembrane proteins for acquisition, active transport, distribution and elimination of Cu ions. In this review we first provide an overview of the literature about the relationship between diabetes and copper, the modulation of Cu(I)-ATPases activity and protein expression in DM, to next discuss the alternative treatments for diabetes using Cu chelation. V C 2017 IUBMB Life, 69(4): [255][256][257][258][259][260][261][262] 2017

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Section: Dm and Disrupted Metal Balancementioning

confidence: 99%

Dissecting copper homeostasis in diabetes mellitus

2017

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“…Given this cluster of modifiable outcomes, as well as their progressive pathophysiological changes, a variety of complementary and alternative medicinal approaches, such as practice of regular exercise, consumption of functional foods and traditional herbal preparations, have been adopted in addition to the pharmacological regimens commonly used at distinct stages of MetS ( Rubio-Ruiz et al, 2013 ). In this scenario, herbal medicines have emerged as the leading source of bioactive molecules to target MetS because of their large-scale phytochemical diversity, which includes numerous flavonoids, and polyphenolic-related compounds ( Arts and Hollman, 2005 ; Galleano et al, 2012 ; Song et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Polyphenol-Rich Extract of Syzygium cumini Leaf Dually Improves Peripheral Insulin Sensitivity and Pancreatic Islet Function in Monosodium L-Glutamate-Induced Obese Rats

et al. 2016

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Syzygium cumini (L.) Skeels (Myrtaceae) has been traditionally used to treat a number of illnesses. Ethnopharmacological studies have particularly addressed antidiabetic and metabolic-related effects of extracts prepared from its different parts, especially seed, and pulp-fruit, however. there is a lack of studies on phytochemical profile and biological properties of its leaf. As there is considerable interest in bioactive compounds to treat metabolic syndrome and its clustered risk factors, we sought to characterize the metabolic effects of hydroethanolic extract of S. cumini leaf (HESc) on lean and monosodium L-glutamate (MSG)-induced obese rats. HPLC-MS/MS characterization of the HESc polyphenolic profile, at 254 nm, identified 15 compounds pertaining to hydrolysable tannin and flavanol subclasses. At 60 days of age, both groups were randomly assigned to receive HESc (500 mg/kg) or vehicle for 30 days. At the end of treatment, obese+HESc exhibited significantly lower body weight gain, body mass index, and white adipose tissue mass, compared to obese rats receiving vehicle. Obese rats treated with HESc showed a twofold increase in lipolytic activity in the periepididymal fat pad, as well as, brought triglyceride levels in serum, liver and skeletal muscle back to levels close those found in lean animals. Furthermore, HESc also improved hyperinsulinemia and insulin resistance in obese+HESc rats, which resulted in partial reversal of glucose intolerance, as compared to obese rats. HESc had no effect in lean rats. Assessment of ex vivo glucose-stimulated insulin secretion showed HESc potentiated pancreatic function in islets isolated from both lean and obese rats treated with HESc. In addition, HESc (10-1000 µg/mL) increased glucose stimulated insulin Syzygium cumini Dual Effect in MSG-Obese Rats secretion from both isolated rat islets and INS-1E β-cells. These data demonstrate that S. cumini leaf improved peripheral insulin sensitivity via stimulating/modulating β-cell insulin release, which was associated with improvements in metabolic outcomes in MSG-induced obese rats.

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“…In Iran, similar to other countries, diabetes is a major health problem and has a high prevalence (around 24%) (Haghdoost et al, 2009). Nowadays, there is a great deal of effort to discover drugs from traditional medicine and enthnopharmacological knowledge to control and/or cure diabetes mellitus by natural products (Chawla et al, 2013;Jarald et al, 2008;Samad et al, 2009;Song et al, 2014;Upendra Rao et al, 2010;Wang and Wylie-Rosett, 2008).…”

Section: Introductionmentioning

confidence: 99%