AIm: Lung cancer is the leading cause of cancer-related mortality worldwide. Pain is a common problem in these patients, yet inadequate or dissatisfactory management is prevalent. mAterIAl and methOds: Between 1987 and 2012, 224 patients with intractable pain were treated with computerized tomography (CT)-guided cordotomy. Among them, 210 had intractable pain due to malignancies. The majority of the cases were diagnosed as pulmonary malignancies (108 patients). Sixty-seven were pulmonary carcinoma, 26 mesothelioma and 15 Pancoast tumors. results: After cordotomy, 98.13% of cancer patients reported initial pain relief. Minimum and maximum preoperative scores of the Karnofsky Performance Scale were 20 and 70, versus postoperative scores of 40 and 90 (p<0.001). The median preoperative VAS score was 8 (6-9). On the first postoperative day, the score dropped sharply to 0 (0-8) (p<0.001). In this selected series of 108 percutaneous cordotomy procedures, as well as in the total series of 224 patients, there was no mortality or major morbidity.COnClusIOn: CT-guided percutaneous cordotomy is an effective procedure that should be used in the treatment of cancer-related pain problems. We suggest that cordotomy should be preferred as soon as possible in patients who fail to respond to the classic analgesic therapy. BulGulAr: Kordotomi uygulaması sonrasında kanser hastalarının % 98,13'ü ağrılarının başlangıçta geçtiğini bildirdiler. Karnofsky Performans Skalası skorlarının preoperatif minimum ve maksimum değerleri 20-70 iken, postoperatif değerler 40-90 idi (p<0,001). Preoperatif VAS skoru ortanca değeri 8 (6-9) idi. Postoperatif ilk günde bu skor bariz olarak 0 (0-8)'a düşmüştür (p<0,001). Toplam 224'lük seride olduğu gibi, seçilen 108 hastanın olduğu perkütan kordotomi serisinde de mortalite veya major morbidite yoktur. sOnuÇ: BT rehberliğinde perkütan kordotomi etkili bir yöntem olup kansere bağlı inatçı ağrıların tedavisinde kullanılması gereklidir. Önerimiz, kordotominin, klasik analjezik terapilere yanıt vermeyen hastalarda zaman kaybedilmeden tercih edilmesi ve kullanılması yönündedir.