Management of Cancer Symptoms: Pain, Depression, and Fatigue: Evidence Report /Technology Assessment, Number 61

Carr, Daniel B.; Goudas, Leonidas C.; Lawrence, Deborah A.; Pirl, William F.; Lau, Joseph; DeVine, Deirdre; Kupelnick, Bruce; Miller, K.

doi:10.1037/e439612005-001

Cited by 88 publications

(82 citation statements)

References 2 publications

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“…1,5 That report estimated cancerrelated pain, depression, and fatigue to range from 14% to 100%, 1% to 42% and 4% to 91%, respectively, including studies of all cancer types and across the cancer (5) 3.76 (4) 3.4 (3) 2.66 (2) 2.6 (2) 2.7 (2) 2.77 (2) 2.08 (1) 1.08 (0)…”

Section: Discussionmentioning

confidence: 99%

Symptom burden and performance status in a population‐based cohort of ambulatory cancer patients

Barbera

Seow

Howell

et al. 2010

Cancer

196

128

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BACKGROUND. For ambulatory cancer patients, Ontario has standardized symptom and performance status assessment population-wide, using the Edmonton Symptom Assessment System (ESAS) and Palliative Performance Scale (PPS). In a broad cross-section of cancer outpatients, the authors describe the ESAS and PPS scores and their relation to patient characteristics. METHODS. This is a descriptive study using administrative healthcare data. RESULTS. The cohort included 45,118 and 23,802 patients' first ESAS and PPS, respectively. Fatigue was most prevalent (75%), and nausea least prevalent (25%) in the cohort. More than half of patients reported pain or shortness of breath; about half of those reported moderate to severe scores. Seventy-eight percent had stable performance status scores. On multivariate analysis, worse ESAS outcomes were consistently seen for women, those with comorbidity, and those with shorter survivals from assessment. Lung cancer patients had the worst burden of symptoms. CONCLUSIONS. This is the first study to report ESAS and PPS scores in a large, geographically based cohort with a full scope of cancer diagnoses, including patients seen earlier in the cancer trajectory (ie, treated for cure). In this ambulatory cancer population, the high prevalence of numerous symptoms parallels those reported in palliative populations and represents a target for improved clinical care. Differences in outcomes for subgroups require further investigation. This research sets the groundwork for future research on patient and provider outcomes using linked administrative healthcare data. Cancer 2010;116:5767-76.

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Section: Discussionmentioning

confidence: 99%

Symptom burden and performance status in a population‐based cohort of ambulatory cancer patients

Barbera

Seow

Howell

et al. 2010

Cancer

196

128

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“…Pain is a common problem in these patients, such that approximately 75% of those with advanced stage cancer experience pain, yet inadequate or dissatisfactory management is prevalent (12,24). Despite the high prevalence of cancer-related pain and the associated disability, it is frequently undertreated (4,6,7,10,30,35).…”

Section: Kanpolat Y Et Al: Ct-guided Percutaneous Cordotomy For Intrmentioning

confidence: 99%

Ct-guided percutaneous cordotomy for intractable pain in what is more than a disease: lung malignancies

Kanpolat

Özdemi̇r²,

Al‐Beyati³

2012

Turkish Neurosurgery

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AIm: Lung cancer is the leading cause of cancer-related mortality worldwide. Pain is a common problem in these patients, yet inadequate or dissatisfactory management is prevalent. mAterIAl and methOds: Between 1987 and 2012, 224 patients with intractable pain were treated with computerized tomography (CT)-guided cordotomy. Among them, 210 had intractable pain due to malignancies. The majority of the cases were diagnosed as pulmonary malignancies (108 patients). Sixty-seven were pulmonary carcinoma, 26 mesothelioma and 15 Pancoast tumors. results: After cordotomy, 98.13% of cancer patients reported initial pain relief. Minimum and maximum preoperative scores of the Karnofsky Performance Scale were 20 and 70, versus postoperative scores of 40 and 90 (p<0.001). The median preoperative VAS score was 8 (6-9). On the first postoperative day, the score dropped sharply to 0 (0-8) (p<0.001). In this selected series of 108 percutaneous cordotomy procedures, as well as in the total series of 224 patients, there was no mortality or major morbidity.COnClusIOn: CT-guided percutaneous cordotomy is an effective procedure that should be used in the treatment of cancer-related pain problems. We suggest that cordotomy should be preferred as soon as possible in patients who fail to respond to the classic analgesic therapy. BulGulAr: Kordotomi uygulaması sonrasında kanser hastalarının % 98,13'ü ağrılarının başlangıçta geçtiğini bildirdiler. Karnofsky Performans Skalası skorlarının preoperatif minimum ve maksimum değerleri 20-70 iken, postoperatif değerler 40-90 idi (p<0,001). Preoperatif VAS skoru ortanca değeri 8 (6-9) idi. Postoperatif ilk günde bu skor bariz olarak 0 (0-8)'a düşmüştür (p<0,001). Toplam 224'lük seride olduğu gibi, seçilen 108 hastanın olduğu perkütan kordotomi serisinde de mortalite veya major morbidite yoktur. sOnuÇ: BT rehberliğinde perkütan kordotomi etkili bir yöntem olup kansere bağlı inatçı ağrıların tedavisinde kullanılması gereklidir. Önerimiz, kordotominin, klasik analjezik terapilere yanıt vermeyen hastalarda zaman kaybedilmeden tercih edilmesi ve kullanılması yönündedir.

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“…In particular, it aims to enhance quality of life at the end of life (eol) 1 . Without effective health care interventions, many cancer patients have uncontrolled symptoms, poor quality of life, and unnecessary suffering [2][3][4][5][6][7][8][9] . The literature suggests that, over time, cancer care is becoming more aggressive near the eol 10,11 .…”

Section: Introductionmentioning

confidence: 99%

Quality of End-of-Life Cancer Care in Canada: A Retrospective Four-Province Study Using Administrative Health Care Data

et al. 2015

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Management of Cancer Symptoms: Pain, Depression, and Fatigue: Evidence Report /Technology Assessment, Number 61

Cited by 88 publications

References 2 publications

Symptom burden and performance status in a population‐based cohort of ambulatory cancer patients

Symptom burden and performance status in a population‐based cohort of ambulatory cancer patients

Ct-guided percutaneous cordotomy for intractable pain in what is more than a disease: lung malignancies

Quality of End-of-Life Cancer Care in Canada: A Retrospective Four-Province Study Using Administrative Health Care Data

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