Management of Breast Sarcoma

Hsu, Cary; McCloskey, Susan A.; Peddi, Parvin F.

doi:10.1016/j.suc.2016.05.004

Cited by 13 publications

(20 citation statements)

References 59 publications

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“…Excisional biopsy should not be performed unless previous attempts at diagnosis were unsuccessful [3, 10, 11]. …”

Section: Discussionmentioning

confidence: 99%

“…The published literature regarding breast sarcomas is predominantly composed of small retrospective analyses and case reports. These studies include patients with a wide variety of histologic features, treated over many decades with great variability in surgical approaches, and inconsistencies on what concerns the effectiveness of adjuvant therapies [10]. PBS is mostly diagnosed in middle-aged patients in their fifth or sixth decade of life [1, 10].…”

Section: Introductionmentioning

confidence: 99%

“…These studies include patients with a wide variety of histologic features, treated over many decades with great variability in surgical approaches, and inconsistencies on what concerns the effectiveness of adjuvant therapies [10]. PBS is mostly diagnosed in middle-aged patients in their fifth or sixth decade of life [1, 10]. The typical patient presents with a painless well-circumscribed and mobile unilateral mass, with variable size (ranging from 1 to 40 cm) and a faster growth rate compared to epithelial breast cancer [1, 10, 11].…”

Section: Introductionmentioning

confidence: 99%

“…PBS is mostly diagnosed in middle-aged patients in their fifth or sixth decade of life [1, 10]. The typical patient presents with a painless well-circumscribed and mobile unilateral mass, with variable size (ranging from 1 to 40 cm) and a faster growth rate compared to epithelial breast cancer [1, 10, 11]. The gross appearance is influenced by the specific histologic features [1, 3].…”

Section: Introductionmentioning

confidence: 99%

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A Scary Onset of a Rare and Aggressive Type of Primary Breast Sarcoma: A Case Report

Ramalho¹,

Campos²,

Rebelo³

et al. 2016

Case Rep Oncol

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Primary breast sarcoma, arising from connective tissue within the breast, is extremely rare, accounting for less than 1% of all primary breast malignancies and no more than 5% of all sarcomas. The rarity of this pathology limits most studies to case reports and small retrospective studies, which has led to a lack of consensus on the clinical management. We report a clinical case of a 52-year-old woman, perimenopausal, previously healthy, with regular breast surveillance, who presented with a large (>20 cm) and rapidly expanding hypervascularized tumor of the left breast developed over 10 days, with a very thin preulcerative skin over the last 4 days. There was no systemic dissemination. The patient was submitted to total mastectomy and excision of axillary adenopathy. The tumor was diagnosed histologically as malignant phyllodes tumor associated with areas of high-grade sarcoma. Due to rapid growth and aggressive histological characteristics, adjuvant chemotherapy and radiotherapy were performed. There is a lot of evidence that tumors larger than 5 cm are associated with a poor prognosis. Despite the poor prognosis associated with this aggressive entity, the patient had no recurrence during 5 years of follow-up. We review the relevant literature about primary breast sarcomas.

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“…Excisional biopsy should not be performed unless previous attempts at diagnosis were unsuccessful [3, 10, 11]. …”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A Scary Onset of a Rare and Aggressive Type of Primary Breast Sarcoma: A Case Report

Ramalho¹,

Campos²,

Rebelo³

et al. 2016

Case Rep Oncol

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“…Furthermore, there are no randomised trials to guide their treatment or provide prognostic factors 3 15 16. Current management strategies are limited to single institution retrospective analysis, case report and extrapolation from treatment of identical sarcomas from other parts of the body 17. In this report, we present a diagnostically challenging case of radiation-induced UPS nearly 20 years following lumpectomy and radiation therapy for invasive breast cancer of the ipsilateral breast.…”

Section: Introductionmentioning

confidence: 99%

Radiation-induced undifferentiated pleomorphic sarcoma of the breast

et al. 2020

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Breast sarcoma is a rare form of malignancy that arises from connective tissue within the breast, comprising less than 5% of all sarcomas. They develop as primary tumours or as secondary following radiation therapy. Diagnosis can be challenging as breast sarcomas are often asymptomatic and resemble benign breast tissue changes. Radiation-induced breast sarcomas present in various forms with an average latency period of 10–20 years following initial radiation therapy. Angiosarcomas are the most common form, while other types such as undifferentiated pleomorphic sarcomas remain rare. Here, we report a case of radiation-induced undifferentiated pleomorphic breast sarcoma in a 75-year-old woman that developed nearly 20 years following breast conserving surgery and radiation for invasive ductal carcinoma. The patient initially noticed a mass in 2017 on self-examination. The mammogram, ultrasound and biopsy at the time showed a benign 2.2 cm nodular fasciitis without malignancy. The mass grew rapidly in the next 6 months to 5.6 cm and repeat biopsy diagnosed undifferentiated pleomorphic sarcoma. The mass abutted the pectoralis muscle but staging workup ruled out distant metastasis and the patient underwent wide local resection of the mass with clear margins. The patient subsequently underwent further postoperative radiation due to insufficient posterior margin width on wide local excision, as chest wall resection would have been required for a wider posterior margin. Prognosis for postradiation sarcomas is generally poor with 27%–36% 5-year survival, with surgical resection as the main line of treatment. The patient currently remains disease-free after 15 months of surveillance.

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Nonepithelial Malignancies of the Breast

Soybir¹

2019

Breast Disease

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Management of Breast Sarcoma

Cited by 13 publications

References 59 publications

A Scary Onset of a Rare and Aggressive Type of Primary Breast Sarcoma: A Case Report

A Scary Onset of a Rare and Aggressive Type of Primary Breast Sarcoma: A Case Report

Radiation-induced undifferentiated pleomorphic sarcoma of the breast

Nonepithelial Malignancies of the Breast

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