Management of Benign Salivary Gland Conditions

Bolk, Kody G.; Mueller, Kurt; Phalke, Neelam; Walvekar, Rohan R.

doi:10.1016/j.suc.2022.01.001

Cited by 2 publications

(6 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There is a paucity of literature examining specific symptom differences between sialadenitis due to sialolithiasis compared to disease from ductal stenosis. Possible reasons for symptom differences include that salivary duct stenosis tends to affect multiple or bilateral glands, whereas sialolithiasis typically presents unilaterally and in the SMGs 2,4 . Stenosis also can be associated with other autoimmune disorders, such as Sjogren's and IgG4‐related disease, which can complicate presentation with other symptoms such as xerostomia 4 .…”

Section: Discussionmentioning

confidence: 99%

“…Possible reasons for symptom differences include that salivary duct stenosis tends to affect multiple or bilateral glands, whereas sialolithiasis typically presents unilaterally and in the SMGs 2,4 . Stenosis also can be associated with other autoimmune disorders, such as Sjogren's and IgG4‐related disease, which can complicate presentation with other symptoms such as xerostomia 4 . Ductal stenosis also proves to be a challenging diagnosis because many imaging techniques are not able to consistently detect ductal abnormalities 16 .…”

Section: Discussionmentioning

confidence: 99%

“…Patients with less severe disease are usually managed medically with oral hydration, sialagogues, and antibiotics. However, for chronic, recurrent, and symptomatic disease, sialendoscopy‐assisted surgeries are minimally invasive interventions used to manage obstructive salivary disease while preserving the involved glands 4 …”

mentioning

confidence: 99%

“…However, for chronic, recurrent, and symptomatic disease, sialendoscopy-assisted surgeries are minimally invasive interventions used to manage obstructive salivary disease while preserving the involved glands. 4 The variable etiologies and intermittent nature of chronic sialadenitis disease limit our knowledge of the predictors for patient improvement with surgery. Validated patient-reported outcome measures (PROMs) such as the Multidisciplinary Salivary Gland Society (MSGS), Oral Health Impact Profile (OHIP-14), Chronic Obstructive Sialadenitis Symptoms Questionnaire (COSS), and the Obstructive Salivary Problem Impact Test (SPIT) have been designed or modified to assess sialadenitis symptoms.…”

mentioning

confidence: 99%

See 3 more Smart Citations

Comparison of Chronic Sialadenitis Symptom Burden in Patients With Sialolithiasis Versus Stenosis Before and After Sialendoscopy

Bhat,

Gulati,

Ryan

et al. 2024

Otolaryngol.--head neck surg.

View full text Add to dashboard Cite

ObjectiveTo define symptomatology and responses to treatment in chronic sialadenitis from sialolithiasis versus duct stenosis and establish a minimal clinically significant difference (MCID) in the validated Obstructive Salivary Problem Impact Test (SPIT).Study DesignProspective, cohort.SettingTertiary‐care center.MethodsPatients completed the SPIT questionnaire at presentation and 3 to 6 months after surgery. SPIT scores and domains were compared between patients with symptomatic sialolithiasis and those with stenosis of a major salivary gland.ResultsSeventy‐nine patients completed the SPIT, including 43 (54%) with sialolithiasis and 36 (46%) with stenosis. Stenosis patients displayed greater baseline scores compared to sialolithiasis patients (45.4 ± 19.9 vs 33.3 ± 18.5, P < .013). Frequency and severity of gland swelling and pain (21.9 ± 8.9 vs 17.1 ± 9.6, P = .02) and functional/psychosocial impact subscores were greater in the stenosis versus sialolithiasis groups (18.0 ± 10.9 vs 11.3 ± 9.4, P < .01). For 43 patients who underwent surgical intervention, SPIT scores improved at 3 to 6 months postoperatively in all domains (−18.6 ± 19.4, P < .01). Degree of improvement did not differ between sialolithiasis versus stenosis groups (−22.0 ± 20.9 vs −13.3 ± 15.8, P = .13). The MCID in SPIT score was found to be −13 points. A postoperative SPIT score of less than 10 suggested symptom resolution.ConclusionWhen compared to sialolithiasis, chronic salivary obstruction from stenosis is associated with greater baseline SPIT scores, indicating poorer sialadenitis‐related quality of life due to greater symptom frequency and functional impact. Based on SPIT survey outcomes, a score decrease of 13 points or SPIT score <10 represent significant symptom improvement.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Comparison of Chronic Sialadenitis Symptom Burden in Patients With Sialolithiasis Versus Stenosis Before and After Sialendoscopy

Bhat,

Gulati,

Ryan

et al. 2024

Otolaryngol.--head neck surg.

View full text Add to dashboard Cite

show abstract

“…Numerous diseases and medical conditions can also affect SG function. SG inflammation, referred to as sialadenitis, can result from SG bacterial or viral infection or recurrent inflammatory disorders and is more prone to occur with hyposalivation and/or duct obstruction [ 46 ]. An incurable autoimmune disease, Sjögren’s syndrome, and radiation therapy for the treatment of head and neck cancer affect many individuals worldwide.…”

Section: Salivary Gland Diseases and Dysfunctionmentioning

confidence: 99%

Bioengineering in salivary gland regeneration

et al. 2022

View full text Add to dashboard Cite

Salivary gland (SG) dysfunction impairs the life quality of many patients, such as patients with radiation therapy for head and neck cancer and patients with Sjögren’s syndrome. Multiple SG engineering strategies have been considered for SG regeneration, repair, or whole organ replacement. An in-depth understanding of the development and differentiation of epithelial stem and progenitor cells niche during SG branching morphogenesis and signaling pathways involved in cell–cell communication constitute a prerequisite to the development of suitable bioengineering solutions. This review summarizes the essential bioengineering features to be considered to fabricate an engineered functional SG model using various cell types, biomaterials, active agents, and matrix fabrication methods. Furthermore, recent innovative and promising approaches to engineering SG models are described. Finally, this review discusses the different challenges and future perspectives in SG bioengineering.

show abstract

Management of Benign Salivary Gland Conditions

Cited by 2 publications

References 61 publications

Comparison of Chronic Sialadenitis Symptom Burden in Patients With Sialolithiasis Versus Stenosis Before and After Sialendoscopy

Comparison of Chronic Sialadenitis Symptom Burden in Patients With Sialolithiasis Versus Stenosis Before and After Sialendoscopy

Bioengineering in salivary gland regeneration

Contact Info

Product

Resources

About