Management of Bacillus Calmette-Guérin osteomyelitis/osteitis in immunocompetent children—A systematic review

Lin, Wen-Li; Chiu, Nan-Chang; Lee, Pin-Hui; Huang, Angela; Huang, Fu‐Yuan; Chi, Hsin; Huang, Daniel Tsung-Ning; Chan, Pei-Chun

doi:10.1016/j.vaccine.2015.07.039

Cited by 42 publications

(73 citation statements)

References 36 publications

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“…Several complications have been reported after the routine immunization program of BCG vaccine. Although some of these are normal vaccine reactions, unexpected complications have been noted [3][4][5][6][7][8][9]. Adverse reactions may be affected with some factors like patient's age, vaccine strains, dosage, erroneous administration, and disturbance of cellular immunity [11].…”

Section: Discussionmentioning

confidence: 99%

“…These lesions heal with scar in approximately 3 months. Although BCG vaccine complications are so rare, in literature erythema, soreness, abscess formation, purulent drainage, ulcer, keloid scar, blistering, regional lymphadenopathy, disseminated BCG-itis, osteomyelitis and osteitis have been reported in some cases [3][4][5][6][7][8][9]. There is no consensus on the treatment of local complications of BCG vaccine.…”

Section: Introductionmentioning

confidence: 99%

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Local Cutaneous Complications After Bacille Calmette-Guerin Vaccine: Experience of a Single Center

et al. 2017

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Background: Bacille Calmette-Guerin (BCG) vaccine may cause some cutaneous complications at the injection site. Although some of these are normal reactions, unexpected complications may be seen. Clinical features, treatment modalities and outcomes of these complications have not been clearly defined in literature. We aimed to determine the local cutaneous complications after BCG vaccine and clinical experiences in our hospital.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Local Cutaneous Complications After Bacille Calmette-Guerin Vaccine: Experience of a Single Center

et al. 2017

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“…Thus, patients undergoing diagnostic procedures instead of surgical interventions may avoid major complications. 8 A previous study presents a case of an infant with BCG osteomyelitis at the proximal tibia with growth disturbance resulting from curettage/biopsy. 9 A meta-analysis was conducted to reveal possible risk factors for the recurrence of the BCG infection.…”

Section: Discussionmentioning

confidence: 99%

Orthopedic Complications in Former Bacillus Calmette-GuÉrin Osteitis Patients

Pöyhönen

Pauniaho

Kröger

et al. 2016

Pediatric Infectious Disease Journal

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“…By contrast, those with BCG osteomyelitis often present with relatively localised symptoms. Of the various symptoms, local tenderness, swelling, and antalgic posturing are the three most commonly reported in the literature [10][11][12] . The clinical manifestations of our cases were comparable with those of previous studies.…”

Section: Discussionmentioning

confidence: 99%

Long-term follow-up of osteomyelitis caused by Bacille Calmette-Guérin vaccination in immunocompetent children

Tsai

Chen

Lai

2020

Sci Rep

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No standard treatment for Bacille Calmette-Guérin (BCG)-associated osteomyelitis, a rare but serious complication of the BCG vaccine, has been established. This study explored the short-and longterm outcomes of surgical intervention for BCG-associated osteomyelitis. Four patients with BCG osteomyelitis aged 9-21 months when diagnosed and treated at the Department of Orthopedics, Kaohsiung Veterans General Hospital, Taiwan, between January 2001 and April 2019 were analysed. Radiography revealed osteolytic lesions of the involved sites. Magnetic resonance imaging revealed physeal involvement in three patients. Debridement was performed for all four patients. One patient then underwent additional arthroscopy because of suspect intra-articular involvement. Specimens obtained intraoperatively were sent for pathology, culture, and to the national reference mycobacterial laboratory for BCG detection using polymerase chain reaction. All four patients had positive results for Mycobacterium bovis and satisfactory short-term results. Functional monitoring using QuickDASH or the Lower Extremity Functional Scale revealed excellent long-term outcomes despite tiny limb length discrepancy observed during follow-up in two patients. Prompt diagnosis plus proper intervention is required to prevent further major complications of BCG osteomyelitis. Minimally invasive debridement led to positive clinical outcomes and is therefore recommended.

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Management of Bacillus Calmette-Guérin osteomyelitis/osteitis in immunocompetent children—A systematic review

Cited by 42 publications

References 36 publications

Local Cutaneous Complications After Bacille Calmette-Guerin Vaccine: Experience of a Single Center

Local Cutaneous Complications After Bacille Calmette-Guerin Vaccine: Experience of a Single Center

Orthopedic Complications in Former Bacillus Calmette-GuÉrin Osteitis Patients

Long-term follow-up of osteomyelitis caused by Bacille Calmette-Guérin vaccination in immunocompetent children

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