Management of Axillary Disease

Caudle, Abigail S.; Cupp, Julie A.; Kuerer, Henry Mark

doi:10.1016/j.soc.2014.03.007

Cited by 40 publications

(28 citation statements)

References 51 publications

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“…Management of axillary lymph node metastases has been a controversial but evolving area of breast cancer therapy (1)(2)(3)(4)(5). Axillary lymph node status is important in predicting local recurrence and long-term outcomes (6,7).…”

Section: Introductionmentioning

confidence: 99%

The value of positive lymph nodes ratio combined with negative lymph node count in prediction of breast cancer survival

Yang

Long

et al. 2017

J. Thorac. Dis.

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Background: Positive lymph node ratio (LNR), defined as ratio of positive lymph nodes to all lymph nodes removed, is a powerful prognostic factor in invasive breast cancer. Here we focused on the impact of negative lymph node (NLN) count on the prediction of value of LNR in breast cancer survival.Methods: Of 929 invasive breast cancer patients were enrolled in our retrospective study. We use KaplanMeier to calculate the 5-year overall survival (OS) according to different clinicopathologic parameters. The prediction value of NLN count and LNR in OS was examined.Results: The optimal cutoff of NLN count was designated as 9. Five-year OS was 77.0% and 95.0% Conclusions: High NLN count is associated with improved survival in invasive breast cancer patients.Combining NLN count with LNR could be considered as an alternative to LNR alone in prediction of postoperative breast cancer survival.

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Section: Introductionmentioning

confidence: 99%

The value of positive lymph nodes ratio combined with negative lymph node count in prediction of breast cancer survival

Yang

Long

et al. 2017

J. Thorac. Dis.

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“…Preoperative assessment of the axilla via physical examination has yielded false-negative rates (FNR) of up to 45% [ 11 ]. Imaging modalities such as ultrasonography, magnetic resonance imaging, and positron emission tomography/computed tomography have also proven to be of limited value in cN0 axilla staging [ 12 13 14 ]. Consequently, surgical staging is the gold standard for assessing the axilla in such patient group.…”

Section: Evolution Of Slnbmentioning

confidence: 99%

“…Although ALND has been the standard treatment modality in this setting, SLNB can potentially spare many of these patients from extensive axillary surgery. Concerns regarding poor identification and high FNR (up to 30% in some studies) in this setting have been expressed [ 14 61 62 ]. NACT and SLNB (upfront or post-NACT) sequencing has been debated extensively, with each approach having its advantages and disadvantages [ 58 59 ].…”

Section: Slnb After Neoadjuvant Chemotherapymentioning

confidence: 99%

Sentinel Lymph Node Biopsy in Breast Cancer: A Clinical Review and Update

et al. 2017

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Sentinel lymph node biopsy has become a standard staging tool in the surgical management of breast cancer. The positive impact of sentinel lymph node biopsy on postoperative negative outcomes in breast cancer patients, without compromising the oncological outcomes, is its major advantage. It has evolved over the last few decades and has proven its utility beyond early breast cancer. Its applicability and efficacy in patients with clinically positive axilla who have had a complete clinical response after neoadjuvant chemotherapy is being aggressively evaluated at present. This article discusses how sentinel lymph node biopsy has evolved and is becoming a useful tool in new clinical scenarios of breast cancer management.

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“…Furthermore, randomized trials are underway with the NRG designed to address the interrelationship of preoperative systemic therapy response in documented node-positive cancer and the need for PMRT and comprehensive nodal irradiation. 17 …”

Section: Impact Of Comprehensive Regional Nodal Irradiation To the Chmentioning

confidence: 99%

Sorting out the Survival Impact of Radiation Therapy in Early-Stage Invasive Breast Cancer

2014

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Management of Axillary Disease

Cited by 40 publications

References 51 publications

The value of positive lymph nodes ratio combined with negative lymph node count in prediction of breast cancer survival

The value of positive lymph nodes ratio combined with negative lymph node count in prediction of breast cancer survival

Sentinel Lymph Node Biopsy in Breast Cancer: A Clinical Review and Update

Sorting out the Survival Impact of Radiation Therapy in Early-Stage Invasive Breast Cancer

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