Management of Aortic Arch Aneurysm Using Profound Hypothermia and Circulatory Arrest

Mahfood, Saade; Qazi, Anjum; García, Jorge; Mispireta, Luis A.; Corso, Paul J.; Smyth, Nicholas P.D.

doi:10.1016/s0003-4975(10)61946-7

Cited by 41 publications

(3 citation statements)

References 15 publications

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“…Indeed, the perfusion time was 137 minutes, and the patient recovered without neurological abnormalities. (2,5,8,9). They hypothesized that the ischaemic tolerance of the spinal cord is increased by deep hypothermia.…”

Section: Adjuncts For Aortic Arch Replacementmentioning

confidence: 99%

Near-total aortic replacement for acute type A dissection in a patient with Marfan syndrome

et al. 2003

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Section: Adjuncts For Aortic Arch Replacementmentioning

confidence: 99%

Near-total aortic replacement for acute type A dissection in a patient with Marfan syndrome

et al. 2003

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“…Hypothermia at temperatures of 20°C is an effective method of protecting the brain [4], and permits toleration of brain ischemia for 40-60 min. Therefore, Correspondence to: Haiime Kin, MD deep hypothermic circulatory arrest has been used as a supportive measure during cardiac surgery [5,6]. However, the duration of ischemia that the brain can withstand under hypothermia has been assessed mainly clinically, and the safe duration of circulatory arrest using deep hypothermic circulatory arrest has not yet been clearly defined.…”

Section: Introductionmentioning

confidence: 99%

Hippocampal Neuronal Death following Deep Hypothermic Circulatory Arrest in Dogs: Involvement of Apoptosis

Kin,

Ishibashi,

Nitatori

et al. 1999

Cardiovascular Surgery

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This study was undertaken to evaluate the histological nature of brain damage caused by deep hypothermic circulatory arrest during cardiopulmonary bypass. Total body cooling to 15°C and rewarming were performed with a conventional cardiopulmonary bypass technique using the femoral artery and vein. Dogs were assigned to one of three groups. In group 1 ( n = 4), cardiopulmonary bypass was maintained in a state of deep hypothermia (15°C) for 90 min, group 2 animals ( n = 5) underwent 60 min of deep hypothermic circulatory arrest at 15°C, and group 3 ( n = 6) underwent 90 min of deep hypothermic circulatory arrest at 15°C. All dogs were killed by perfusion fixation 72 h after cardiopulmonary bypass. The CA1 regions of the hippocampi were examined by light and electron microscopy. Biotinylated dUTP was used for nick-end labeling of apoptotic cells mediated by terminal deoxytransferase. No morphological change was observed in group 1 dogs, and very little in group 2 dogs. More severe neuronal damage was observed in group 3. The nuclei of many cells were shrunken and showed nick-end labeling. Dense chromatin masses were detected electron microscopically in the nuclei of CA1 pyramidal cells. Neuronal cell death observed in CA1 pyramidal cells 72 h after 90 min of deep hypothermic circulatory arrest at 15°C involves apoptosis. Therefore, according to this model, the maximum duration of deep hypothermic circulatory arrest should not be allowed to exceed 60 min.

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“…part of the aorta include hypothermic cardiopulmonary bypass (CPB) with selective cerebral perfusion (SCP)," hypothermic CPB with circulatory arrest [4][5][6][7] and hypothermic CPB with retrograde cerebral perfusion.' Usui9 reviewed early clinical results in retrograde cerebral perfusion and selective cerebral perfusion in Japanese many institutions, and found those circulatory support techniques and surgical procedures differed greatly among institutions during aortic arch surgery.…”

mentioning

confidence: 99%

Cerebral protection selection in aortic arch surgery for patients with preoperative complications of cerebrovascular disease

Akashi

Tayama

Fujino

et al. 2000

Jpn J Thorac Caridovasc Surg

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Management of Aortic Arch Aneurysm Using Profound Hypothermia and Circulatory Arrest

Cited by 41 publications

References 15 publications

Near-total aortic replacement for acute type A dissection in a patient with Marfan syndrome

Near-total aortic replacement for acute type A dissection in a patient with Marfan syndrome

Hippocampal Neuronal Death following Deep Hypothermic Circulatory Arrest in Dogs: Involvement of Apoptosis

Cerebral protection selection in aortic arch surgery for patients with preoperative complications of cerebrovascular disease

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