Management of anal intraepithelial neoplasia and anal squamous cell carcinoma at a tertiary referral centre with a dedicated infectious diseases unit: an 18-year review

Foley, Megan Power; Kelly, Maureen; Kerr, Colm; Kennedy, Cormac; Gallagher, David J.; Gillham, Charles; Mehigan, Brian; McCormick, Paul; Bergin, Colm; Larkin, John

doi:10.1007/s00384-020-03640-9

Cited by 6 publications

(2 citation statements)

References 40 publications

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“…10 However, it has been reported in an Irish anal cancer population that HPV-positive patients were diagnosed significantly younger. 11 The impact of p16 status on histological characteristics Our data does not show a significant relationship between p16 INK4a positivity and tumour stage, nodal status, LVSI or PNI. This is consistent with previous studies.…”

Section: Hpv Prevalence In An Irish Penile Cancer Cohortcontrasting

confidence: 53%

The relationship of human papillomavirus positivity with tumor characteristics in an Irish penile cancer population

Browne

Foley

O'Kelly

et al. 2022

CUAJ

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Introduction: Penile cancer is a rare malignancy, with a European-wide annual incidence rate of 1/100 000 males. Approximately one-third of cases are attributable to human papillomavirus (HPV) infection. p16INK4a is a recognized surrogate marker for HPV infection in penile cancer. University Hospital Waterford (UHW) is the national referral center for penile cancer in Ireland. We report the prevalence of HPV infection and histological characteristics of an Irish penile cancer cohort using p16INK4a as a surrogate marker. Methods: Patients who attended UHW for penile cancer surgery between June 2015 and November 2020 were entered into a prospectively maintained database. Clinical, histopathological, and outcome data were collected. Results: Over the study period, 70 patients with a histological diagnosis of penile squamous cell carcinoma had staining for p16INK4a, of whom 64% were positive. p16INK4a positive patients were significantly younger at diagnosis, with a mean age of 61±15 years compared to 68±12 (p <0.05). Of note, 97% of tumors with high-risk histology were p16INK4a positive (p<0.001). p16INK4a positivity was more prevalent among higher-grade tumors (p<0.02). Interestingly, p16INK4a status was not associated with recurrence-free or overall survival. Conclusions: Our data is representative of the Irish landscape in penile cancer over the last five years. Using p16INK4a staining, we demonstrate a high rate of HPV prevalence in penile cancer cases in our patient cohort, which is associated with prognostically worse tumor subtypes. This would suggest that HPV vaccination of adolescent boys is a useful public health intervention in preventing penile cancer in the Irish male population.

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Section: Hpv Prevalence In An Irish Penile Cancer Cohortcontrasting

confidence: 53%

The relationship of human papillomavirus positivity with tumor characteristics in an Irish penile cancer population

Browne

Foley

O'Kelly

et al. 2022

CUAJ

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“…Patients at risk for anal cancer include PLWH, MSM, women diagnosed with HPV-related gynaecological precancerous lesions or cancer, solid organ transplant recipients (SOTR), patients with autoimmune diseases as well as smokers (31)(32)(33)(34)(35)(36)(37). One of the common links between patients at risk is an immunocompromised status (viral or anti-rejection medication).…”

Section: Anal Cancermentioning

confidence: 99%

Diagnosis and screening for anal intraepithelial neoplasia in Belgium: position statement

Roelandt¹,

Looze²,

Schepper³

et al. 2022

AGEB

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Anal cancer is an uncommon malignancy, comprising only 2.5% of all gastrointestinal malignancies and similar to cervical cancer, the human papillomavirus (HPV) is responsible for the majority of anal cancers. Over the last decades there has been an up to 3-fold increased incidence seen in specific populations at risk such as persons living with HIV (PLWH), men who have sex with men (MSM), woman diagnosed with HPV-related gynaecological precancerous lesions or cancer, solid organ transplant recipients (SOTR) and patients with autoimmune diseases. Although international practice is evolving increasingly towards active screening for and treatment of anal cancer precursors in at-risk groups, currently no organised screening program is in effect in Belgium. Currently, differerent screening options as well as treatment modalities are available. Before commencing a nationwide organised screening program, essential decisions on screening strategies need to be made, based on both scientific as well as financial and logistical facts.

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Our experience in the short-term diagnostic-therapeutic management of the patient with anal dysplasia

Martínez

Casanovas²,

Vilaplana³

et al. 2023

Cirugía Española (English Edition)

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Management of anal intraepithelial neoplasia and anal squamous cell carcinoma at a tertiary referral centre with a dedicated infectious diseases unit: an 18-year review

Cited by 6 publications

References 40 publications

The relationship of human papillomavirus positivity with tumor characteristics in an Irish penile cancer population

The relationship of human papillomavirus positivity with tumor characteristics in an Irish penile cancer population

Diagnosis and screening for anal intraepithelial neoplasia in Belgium: position statement

Our experience in the short-term diagnostic-therapeutic management of the patient with anal dysplasia

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