Management of Airway Manifestations of Relapsing Polychondritis

Sarodia, Bipin D.; Dasgupta, Asok; Mehta, Atul C.

doi:10.1378/chest.116.6.1669

Cited by 123 publications

(75 citation statements)

References 15 publications

(50 reference statements)

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“…Airway management along with early pharmacotherapy can lead to relief of symptoms. 2,7,9 Glucocorticoids, other immunosuppressive agents (such as methotrexate, cyclophosphamide, colchicine, and azathioprine), and anti-tumor necrosis factor agents have been used with varying outcomes [10][11][12][13][14][15][16] Relapse of the disease is common when therapy is tapered off.…”

Section: Discussionmentioning

confidence: 99%

Respiratory Failure Secondary to Relapsing Polychondritis

2014

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Section: Discussionmentioning

confidence: 99%

Respiratory Failure Secondary to Relapsing Polychondritis

2014

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“…6 Most patients with airway manifestations are stabilized with supportive treatment. 8 Noninvasive ventilation could be a treatment of choice for airway involvement in relapsing polychondritis to keep the narrowed airways from collapsing. 9 In the case we reported, the obstruction was so severe as to result in acute respiratory failure and NPPE.…”

Section: Discussionmentioning

confidence: 99%

Relapsing Polychondritis With Initial Presentations of Recurrent Negative-Pressure Pulmonary Edema and Acute Respiratory Failure

Wu¹,

Li²,

Hung³

et al. 2014

Respir Care

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Relapsing polychondritis is a rare autoimmune disease causing inflammation in cartilaginous structures and other tissues throughout the body. Negative-pressure pulmonary edema (NPPE) due to laryngeal swelling from relapsing polychondritis is rare and has not been reported. Here, we report a case of relapsing polychondritis in an 18-y-old female who presented with recurrent NPPE and acute respiratory failure, which was diagnosed initially as ARDS during the influenza season.

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“…Airway involvement is considered to be a major prognostic factor (14). Inflammation and destruction of tracheobronchial cartilages caused airway edema, airway collapse (tracheobronchomalacia), and cicatricial stenosis of the airways.…”

Section: Discussionmentioning

confidence: 99%

“…The disappearance of the tracheal cartilage ring by bronchoscopy suggested advanced cartilage destruction, consistent with a flow-volume curve indicating the pattern of intrathoracic airway stenosis. Since common causes of death in RPC patients included respiratory failure and airway infection, insertion of a tracheobronchial stent must be considered (3,14).…”

Section: Discussionmentioning

confidence: 99%

A Patient with Relapsing Polychondritis who Had Been Diagnosed as Intractable Bronchial Asthma

et al. 2012

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A 62-year-old woman, diagnosed as bronchial asthma 3 years previously, was admitted due to acute severe dyspnea. Physical examination revealed saddle nose, flare/swelling of the ear auricles, and stridor. Computed tomography demonstrated thickening of tracheal/bronchial walls and stenosis of the lumen that deteriorated on expiration, suggesting tracheobronchomalacia. Auricle biopsy indicated cartilage destruction. Based on these findings, the patient was diagnosed as relapsing polychondritis. As demonstrated in this case, relapsing polychondritis involving airways might be misdiagnosed as bronchial asthma due to stridor and transient corticosteroid-related improvement. Early diagnosis is necessary to prevent irreversible airway stenosis and progression to tracheobronchomalacia.

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Management of Airway Manifestations of Relapsing Polychondritis

Cited by 123 publications

References 15 publications

Respiratory Failure Secondary to Relapsing Polychondritis

Respiratory Failure Secondary to Relapsing Polychondritis

Relapsing Polychondritis With Initial Presentations of Recurrent Negative-Pressure Pulmonary Edema and Acute Respiratory Failure

A Patient with Relapsing Polychondritis who Had Been Diagnosed as Intractable Bronchial Asthma

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