Management of Adult Syphilis: Key Questions to Inform the 2015 Centers for Disease Control and Prevention Sexually Transmitted Diseases Treatment Guidelines: Table 1.

Abstract

A panel of experts generated 8 "key questions" in the management of adult syphilis. A systematic literature review was conducted and tables of evidence were constructed to answer these important questions. Penicillin is the drug of choice to treat syphilis. Doxycycline to treat early and late latent syphilis is an acceptable alternate option if penicillin cannot be used. There is no added benefit to enhanced antimicrobial therapy when treating human immunodeficiency virus-infected persons with syphilis. If a patient misses a dose of penicillin in a course of weekly therapy for late syphilis, clinical experience suggests that an interval of 10-14 days between doses might be acceptable before restarting the sequence of injections. Pharmacologic considerations suggest that an interval of 7-9 days between doses, if feasible, may be more optimal. Missed doses are not acceptable for pregnant women. A cerebrospinal fluid examination to diagnose neurosyphilis is recommended in persons diagnosed with tertiary syphilis (eg, cardiovascular syphilis or late benign syphilis), persons with neurological signs or symptoms consistent with neurosyphilis, and asymptomatic persons whose serological titers do not decline appropriately following recommended therapy and in whom reinfection is ruled out. Infection and reinfection rates, particularly among men who have sex with men, are high. Frequent serological screening of this population appears to be the most cost-efficient intervention. The Centers for Disease Control and Prevention continues to recommend the use of the traditional rapid plasma reagin-based screening algorithm. The positive predictive value for syphilis associated with an isolated unconfirmed reactive treponemal chemiluminescence assay or enzyme immunoassay is low if the epidemiological risk and clinical probability for syphilis are low. Among pregnant women with serodiscordant serologies ( positive treponemal tests and a negative nontreponemal test), the risk of vertical transmission from mother to infant is low. Several important questions regarding the management of syphilis remain unanswered and should be a priority for future research.

Late Neurosyphilis and Tertiary Syphilis in Guangdong Province, China: Results from a Cross-sectional Study

“…As a result, a greater proportion of syphilis cases progress to neurosyphilis and tertiary syphilis. Many studies and reports recommend that physicians should screen neurosyphilis in patients with clinical signs and symptoms of central nervous system involvement, HIV infection, serum titer > = 1:32 or with documented treatment failure of syphilis101718. It has been advised that China should adapt the same recommendation and should initiate screening as early as possible.…”

Syphilitic Proctitis

“…From 2005 to 2013, the Centers for Disease Control and Prevention estimated that the number of primary and secondary syphilis cases reported had almost doubled from 8,724 to 16,663. (2).…”

Syphilis

“…Penicillin G benzathine (2.4 million units intramuscularly) once weekly for three weeks is the standard therapy for late syphilis [43]. If the patient misses a dose or more than 14 days have elapsed since the prior dose, the course should be reinitiated [56]. Patients with gummatous or cardiovascular infection should have a CSF examination prior to therapy to assess for neurosyphilis.…”