Management of adult soft tissue sarcomas of the head and neck

Maxillary Sinus Sarcomas: Epidemiological and Clinicopathological Experience of 25 Years in a National Reference Cancer Center

“…Second, the evaluation and monitoring of patients was based on radiographic studies with technology (hardware and software) continuously changed over the years, improving the assessment of patients. Third, the classification of sarcomas has evolved, are a heterogeneous group of at least 50 histological subtypes, each with its own histological variants classified according to their supposed origin tissue [2], but today we know that sarcomas originate from a pluripotent stem cell can differentiate into any mesenchymal component, so that today the classification is based on the phenotype of the tumor. With advances in the field of immunohistochemistry (IHC) and molecular biology: now, we can classify more properly these tumors even in small samples [3].…”

“…We used the American Join Committee on Cancer (AJCC) staging system at its seventh revision (2010), taking into account the clinical, radiological and pathological data (including surgical limits) in addition to those established by the College of American Pathologists (CAP) [9] in the same year; In summary, R2 is considered when grossly visible tumor is in the limit section, R1 is the presence of microscopic tumor at the edge section and R0 means surgical margin free of neoplasia. The histological gradificación system used was the French system FNCLCC (Fédération Nationale de Centres de Lutte Contre le Cancer) based on 3 grades [2] for which use the criteria established by Trojani [10] that evaluates necrosis, nuclear pleomorphism and mitosis. All surgical specimens or biopsies were reviewed histologically to determine the margin status, confirm the histological diagnosis and grading tumors.…”

“…One of the main determinants of the biological behavior of these sarcomas is tumor grade, which correlates with lymph node metastasis, distant metastasis, recurrence, positive margins and overall survival [2,5,22]. Gradificación systems based on histological parameters were introduced in the eighties to provide more precise information on the degree of malignancy of tumors.…”

“…Soft tissue sarcomas comprise more than 50 different histological subtypes with a wide spectrum of biological behavior, most are slow growing, locally aggressive, but lymph node metastases occur only in 3-10% and distant metastases in 28% (most commonly in lung, bone, liver and central nervous system). The metastasis are more common in high grade sarcomas [2].…”

Optimization of a Neutron Beam Shaping Assembly Design for BNCT and Its Dosimetry Simulation Based on McNPX

“…Soft-tissue sarcoma is rare, with an annual incidence around 5 per 100,000 [1]. Malignant fibrous histiocytoma, fibrosarcoma, angiosarcoma and malignant peripheral nerve sheath tumor are the most frequently found sarcoma types in the head and neck [2]. Soft tissue sarcomas account for the majority (80%) of all sarcomas in the human body and constitute about 20% of all sarcomas affecting the head and neck regions in adults and approximately 35% in children.…”