The response of the dentoalveolar apparatus to infection is characterized by inflammation which may result in tooth resorption .External apical root resorption in permanent dentition is usually pathological. Local factors are the most frequent causes of resorption, especially excessive pressure and inflammation. Depending upon the type of resorption and etiology, different treatment regimens have been proposed. The risk of development of inflammatory or replacement root resorption is high if not timely managed. Endodontic intervention is required soon after the occurrence of trauma, in an attempt to prevent or delay inflammatory root resorption. The present case demonstrates external root resorption arrest and formation of an apical barrier by conventional endodontic therapy combined with calcium hydroxide dressing and a mineral trioxide aggregate (MTA) apical plug. The upper right central incisor and lateral incisior exhibited severe external root resorption, and a periapical radiolucent lesion received root canal treatment combined with calcium hydroxide dressing for over 1 month. The dressing was renewed every 15 days, and the coronal portion was sealed with composite resin. After detection of the apical barrier, a MTA apical plug backfilled with guttapercha was performed and the access cavity was restored with composite resin. The patient has been regularly recalled every 6 months, and no symptoms or signs have been noted. Radiography showed the apical lesion healed and the external root resorption had been arrested after18 month follow up.