Management of a parturient with high-grade osteosarcoma of the proximal femur: a multidisciplinary approach

Quaye, A.A.; Raskin, Kevin A.; Ecker, J.L.; Leffert, Lisa

doi:10.1016/j.ijoa.2010.03.013

Cited by 7 publications

(2 citation statements)

References 10 publications

(10 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It occurs mainly in children and adolescents with a very high tendency for local invasion and early systemic metastases (1,2). Generally, it is considered an aggressive malignancy that arises from mesenchymal origin which exhibits osteoblastic differentiation and produces malignant osteoid matrix (2).…”

Section: Introductionmentioning

confidence: 99%

Sinomenine prevents metastasis of human osteosarcoma cells via S phase arrest and suppression of tumor-related neovascularization and osteolysis through the CXCR4-STAT3 pathway

Xie

Ren

Lin

et al. 2016

International Journal of Oncology

View full text Add to dashboard Cite

Abstract. Osteosarcoma is the most common primary malignant tumor of the bone. The long-term survivals continue to be unsatisfactory for patients with metastatic and recurrent disease. Metastasis is still a severe challenge in osteosarcoma treatment. Sinomenine, an alkaloid from traditional Chinese medicine, has been proved to possess potent antitumor and anti-invasion effect on various cancers. However, the effect of sinomenine on human osteosarcoma and the underlying mechanisms remains unknown. We report here that sinomenine inhibited proliferation by inducing S phase arrest and suppressing the clone formation. Significant inhibitory effects were found in invasion and metastasis in osteosarcoma, but little cytotoxicity was observed in tested concentrations. Exposure to sinomenine resulted in suppression of invasion and migration in osteosarcoma cells as well as tube formation ability in the human umbilical vein endothelial cells (HUVEC) and U 2 OS cells. Furthermore, it demonstrated that CXCR4 played a key role contributing to invasion in osteosarcoma which is considered to be a core target site in sinomenine treatment. Sinomenine inhibited invasion by suppressing CXCR4 and STAT3 phosphorylation then downregulating the expression of MMP-2, MMP-9, RANKL, VEGF downstream. In addition, then RANKL-mediated bone destruction stimulated by osteoclastogenesis and VEGF-related neovascularization were restrained. Importantly, in vivo, sinomenine suppressed proliferation, osteoclastogenesis and bone destruction. Through these various comprehensive means, sinomenine inhibits metastasis in osteosarcoma. Taken together, our results revealed that sinomenine caused S phase arrest, inhibited invasion and metastasis via suppressing the CXCR4-STAT3 pathway and then osteoclastogenesis-mediated bone destruction and neovascularization in osteosarcoma. Sinomenine is therefore a promising adjuvant agent for metastasis control in osteosarcoma.

show abstract

Section: Introductionmentioning

confidence: 99%

Sinomenine prevents metastasis of human osteosarcoma cells via S phase arrest and suppression of tumor-related neovascularization and osteolysis through the CXCR4-STAT3 pathway

Xie

Ren

Lin

et al. 2016

International Journal of Oncology

View full text Add to dashboard Cite

show abstract

“…The existing literature contains only anecdotal individual case reports and small studies on cancers during pregnancy [3][4][5][6][7]. This review was undertaken to report the anesthetic management of labor and delivery in patients at our institution who were diagnosed with cancer before and during pregnancy.…”

Section: Introductionmentioning

confidence: 99%

Anesthetic management during labor and delivery: a 21-year review of women with cancer in a tertiary care center

Tharmaratnam

Balki

2012

Journal of Clinical Anesthesia

View full text Add to dashboard Cite

Ostéosarcome

Fuzier¹

2015

Prise en Charge Des Maladies Rares en Anesthésie Et Analgésie Obstétricales

View full text Add to dashboard Cite

Management of a parturient with high-grade osteosarcoma of the proximal femur: a multidisciplinary approach

Cited by 7 publications

References 10 publications

Sinomenine prevents metastasis of human osteosarcoma cells via S phase arrest and suppression of tumor-related neovascularization and osteolysis through the CXCR4-STAT3 pathway

Sinomenine prevents metastasis of human osteosarcoma cells via S phase arrest and suppression of tumor-related neovascularization and osteolysis through the CXCR4-STAT3 pathway

Anesthetic management during labor and delivery: a 21-year review of women with cancer in a tertiary care center

Ostéosarcome

Contact Info

Product

Resources

About