Management of a Hypomineralisation of the Enamel by Applying a Remineraliser Based on Zinc Hydroxyapatite (microRepair)

Solinas, Giuliana; Grabesu, V.; Lattari, M; Strinna, R.; Arnould, N.; Amodeo, AA

doi:10.1155/2021/5291858

Cited by 4 publications

(9 citation statements)

References 18 publications

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“…(Bakkal et al, 2017;Biondi et al, 2017;Restrepo et al, 2016). This approach is based on the concept that increasing the mineral component in teeth affected by MIH can lead to an improvement of the physical structure of the enamel together with its aesthetic appearance, and to the decrease of dental sensitivity (Solinas et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

“…Molar–incisor hypomineralization (MIH) is a delimited qualitative developmental defect leading to several dental complications, like hypersensitive teeth, increased susceptibility to caries, impaired chewing due to rapid tooth loss, and aesthetic defects; this condition may significantly affect patients' quality of life, so a correct diagnosis and treatment plan are strictly required (Solinas et al, 2021). To date, different clinical trials have been conducted to evaluate the efficacy of remineralizing agents like fluoride in different formulations, casein‐based mousses and amorphous calcium phosphate (CPP‐ACP), and hydroxyapatite (Bakkal et al, 2017; Biondi et al, 2017; Restrepo et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

“…In this study, the primary outcome was pain sensation in response to tactile stimulus (Wong-Baker FACES Pain Rating Scale) 56 days after randomization.The results of the trial did not show the non-inferiority in hypersensitivity relief of the toothpaste containing hydroxyapatite compared to amine fluoride; however, the hydroxyapatite group tended to be less hypersensitive. In a pediatric sample, it was demonstrated that worse oral health quality of life is associated with MIH as regard oral symptoms(Portella et al, 2019) Therefore, a reduction in hypersensitivity with domiciliary treatment could surely bring to an improvement in MIH children's quality of life, as it is one of the major concerns during both daily life and dental treatment(Mendonça et al, 2022).In their recent case report,Solinas et al (2021) described the case of a 4-years-old female patient complaining of hypersensitivity to heat and cold, even during normal breathing. The patient presented hypomineralization of the enamel on permanent upper and lower incisors and left lower first permanent molar.…”

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confidence: 99%

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Biomimetic hydroxyapatite paste for molar–incisor hypomineralization: A randomized clinical trial

et al. 2022

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ObjectivesThe aim of this randomized clinical trial was to evaluate the desensitizing and remineralizing effect of a new zinc‐hydroxyapatite‐based paste in sites affected by molar–incisor hypomineralization (MIH), by assessing dental sensitivity, tooth wear, and periodontal indexes.Materials and MethodsTwenty‐five patients with presence of 1 enamel demineralization of permanent molars and incisors in two different quadrants were recruited. After professional dental hygiene, a domiciliary hydroxyapatite‐based paste was assigned and recommended to be applied on 2 MIH teeth in one random quadrant (test group), while the 2 contralateral MIH teeth did not undergo paste application (control group). The following primary outcomes were assessed: Plaque Control Record (PCR), Bleeding Index (BI), MIH Treatment Need Index (MIH‐TNI), and Schiff Air Index (SAI).ResultsNo significant inter‐ and intragroup differences were found for PI and BI, except for both intragroup T0–T1. For MIH‐TNI, significant intergroup differences were detectable in the test group after 9 months of treatment. For SAI values, no significant differences were found in the control group, while in the test group, significant lower values were found after 1 and 3 months since baseline, respectively.Conclusions and Clinical RelevanceBiomimetic zinc‐hydroxyapatite showed a desensitizing effect when used to treat MIH.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Biomimetic hydroxyapatite paste for molar–incisor hypomineralization: A randomized clinical trial

et al. 2022

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“…A recent study by Solinas et al [17] reported that the application of biomimetic nanohydroxyapatite for the treatment of incisor and molar hypomineralization for six months in a 4-year-old patient resulted in a significant decrease in the hypersensitivity and improved the enamel appearance for the maxillary incisors. Further studies to evaluate the effect of biomimetic nanohydroxyapatite are recommended in hope that more invasive treatment options can be avoided.…”

Section: Discussionmentioning

confidence: 99%

“…Conservative methods for remineralization usually include proper oral hygiene measures, which requires patient's compliance and involves multiple applications of fluorides, and/or casein phosphopeptide-amorphous calcium phosphate containing products [14,15]. Recently, a few studies reported that the use of biomimetic hydroxyapatite containing toothpaste forms a coating on the enamel surface, promotes superficial enamel repair, and aids in preventing secondary caries around restorations [16,17,18].…”

Section: Introductionmentioning

confidence: 99%

Patient Satisfaction with Resin Infiltration Treatment for Masking Noncavitated White Spot Lesions on Anterior Maxillary Teeth: Two Case Reports

Alamoudi

Yaseen

Alharthi

et al. 2022

Case Reports in Dentistry

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Aim. We assessed patient satisfaction with resin infiltration treatment outcomes for masking postorthodontic treatment noncavitated white spot lesions on anterior maxillary teeth. Background. White spot lesions (WSLs) are opaque white areas of demineralization. The lesion may remineralize over time, but the opaque color usually remains, retaining the undesirable tooth color. Case Description: Resin infiltration (RI) was administered to two patients with a total of 10 anterior maxillary teeth diagnosed with noncavitated WSLs. Immediately after treatment, patients were asked about their comfort during the RI treatment and their level of satisfaction with treatment outcomes. Two weeks post-treatment, the two patients were asked again about their level of treatment outcome satisfaction and if they thought they needed a second treatment. Both reported that they were comfortable during the treatment and were extremely satisfied with the achieved treatment outcomes immediately and two weeks after the treatment and did not feel that they would need to seek further treatment to reach the desired outcome. Conclusion. Resin infiltration is a comfortable, conservative treatment option providing satisfactory outcomes in masking noncavitated WSLs on anterior maxillary teeth after orthodontic treatment. Clinical Significance. Resin infiltration is a conservative treatment option to mask noncavitated WSLs after orthodontic treatment.

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Remineralization Strategies for Teeth with Molar Incisor Hypomineralization (MIH): A Literature Review

Enax

Farah

Liu³

et al. 2023

Dentistry Journal

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Molar incisor hypomineralization (MIH) is a highly prevalent dental developmental disorder with a significant health burden for patients and high treatment needs, yet no comprehensive review article on all remineralization systems as a non-invasive treatment approach for MIH has been published. Typical characteristics of MIH-affected teeth are a lower mineral density and lower hardness compared to healthy teeth leading to sensitivity and loss of function. Thus, the use of formulations with calcium phosphates to remineralize MIH-affected teeth is reasonable. This review presents an up-to-date overview of remineralization studies focusing on active ingredients investigated for remineralization of MIH, i.e., casein phosphopeptide amorphous calcium phosphate (CPP-ACP), casein phosphopeptide amorphous calcium fluoride phosphate (CPP-ACFP), hydroxyapatite, calcium glycerophosphate, self-assembling peptide, and fluoride. Overall, 19 studies (in vitro, in situ, and in vivo) were found. Furthermore, an additional search for studies focusing on using toothpaste/dentifrices for MIH management resulted in six studies, where three studies were on remineralization and three on reduction of sensitivity. Overall, the studies analyzed in this review showed that MIH-affected teeth could be remineralized using calcium phosphate-based approaches. In conclusion, calcium phosphates like CPP-ACP, calcium glycerophosphate, and hydroxyapatite can be used to remineralize MIH-affected teeth. In addition to MIH-remineralization, CPP-ACP and hydroxyapatite also offer relief from MIH-associated tooth sensitivity.

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Management of a Hypomineralisation of the Enamel by Applying a Remineraliser Based on Zinc Hydroxyapatite (microRepair)

Cited by 4 publications

References 18 publications

Biomimetic hydroxyapatite paste for molar–incisor hypomineralization: A randomized clinical trial

Biomimetic hydroxyapatite paste for molar–incisor hypomineralization: A randomized clinical trial

Patient Satisfaction with Resin Infiltration Treatment for Masking Noncavitated White Spot Lesions on Anterior Maxillary Teeth: Two Case Reports

Remineralization Strategies for Teeth with Molar Incisor Hypomineralization (MIH): A Literature Review

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