Management of a hypertensive ulcer with an epidermal growth factor-based formulation

Hernández-Cañete, Carlos M; Betancourt, Blas Y

doi:10.12968/jowc.2008.17.9.30935

Cited by 3 publications

(1 citation statement)

References 14 publications

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“…Except for becaplermin treatment of diabetic ulcers, randomized controlled trial results using topical growth factors for chronic wounds have been disappointing, 17 suggesting that growth factors might be rapidly degraded by wound proteases or that wound cells have decreased proliferative ability. To date, no medical management of HLU has emerged, 23 and surgical management by grafting, to achieve complete healing, remains the most promising treatment strategy but should be evaluated in a randomized controlled trial.…”

Section: Resultsmentioning

confidence: 99%

Topical Treatment of Hypertensive Leg Ulcers With Platelet-Derived Growth Factor-BB

Senet

Vicaut²,

Bénéton³

et al. 2011

Arch Dermatol

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Setting: Ambulatory or hospitalized patients from 17 dermatology departments. Patients: Among 64 consecutive randomized patients with 1 or more hypertensive leg ulcers who fulfilled all inclusion criteria, 59 received the allocated intervention, and findings were analyzed. Intervention: Becaplermin gel (human recombinant platelet-derived growth factor-BB, 0.1%, in hydrogel) or hydrogel dressing was applied, both in doses of 1 cm/ cm 2 , once daily for 8 weeks. Follow-up continued for 4 weeks beyond the final gel application. Main Outcome Measures: The primary end point was complete wound closure rate after 8 weeks of treatment. Secondary end points were percentages of patients with complete wound closure at week 12; changed ulcer area after treatment vs baseline; and changed ulcerrelated pain and health-related quality of life during the study. Results: Complete wound closure rates were comparable after 8 weeks for becaplermin (5 of 28 patients) and hydrogel (3 of 31 patients) (8 percentage-point difference; 95% confidence interval,-10% to 26%). No statistically significant differences were observed between the 2 groups for percentages of complete closure at week 12, changed ulcer area at week 8, or changed ulcer-related pain and quality of life during the study (PϾ.05 for all comparisons). Conclusions: Topical becaplermin gel is not superior to hydrogel dressing for hypertensive leg ulcer wound closure. Surgical management by grafting remains the most promising treatment strategy but requires further evaluation.

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Section: Resultsmentioning

confidence: 99%