Management of a diabetic foot ulcer with a Myrtle (M. communis) gel based on Persian medicine: A case report

Khodaie, Seyed-Ali; Khalilzadeh, Saeid Hossein; Emadi, Fatemeh; Kamalinejad, Mohammad; Hajati, Razieh Jafari; Naseri, Mohsen

doi:10.1016/j.aimed.2020.08.008

Cited by 7 publications

(2 citation statements)

References 17 publications

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“…Many products of traditional medicine are prepared from the extract or essential oil of this plant (35,36). In Persian medicine, it was believed that Myrtle possessed wound healing, hemostatic, and astringent effects (37). According to Persian medicine manuscripts, the combination of sugar and aqueous extract of M. communis fruit as a syrup is an ancient remedy for pneumonia accompanied by coughs and diarrhea (38).…”

Section: Myrtus Communis Lmentioning

confidence: 99%

Efficiency of Herbal Medicines in Containment of COVID-19

Sarahroodi

2021

Electron Physician

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Background: SARS-CoV-2 is the causative agent of the novel coronavirus disease (COVID-19). This virus is responsible for the pandemic which has resulted in the current global health crisis. Remdesivir is now used as an FDA-approved medication in addition to some emergency use authorization (EUA) agents such as Actemra (Tocilizumab), Sotrovimab, and REGEN-COV (Casirivimab and Imdevimab) to contain the COVID-19 infection. However, they are not 100% effective in all cases, and there are several hundreds of daily deaths worldwide. Furthermore, since nearly one year as of the beginning of global vaccination, various vaccines have been evaluated not completely efficient in containing new variants of SARS-CoV-2, although they have significantly reduced mortality. Herbal medicines with evidence-based beneficial effects can have positive roles in immunity enhancement, prevention of infection, and antiviral effects. This review presents the updates of some herbal medicines that may have potential effects on the containment of the COVID-19, especially those with antitussive, antipyretic, anti-viral, anti-inflammatory, and antioxidant effects. Methods: In this narrative review, a thorough literature review was conducted on the entries of Google Scholar, PubMed, Web of Science (Clarivate Analytics), Scopus and, and Science Direct published since 2019. This study includes the recently published papers, randomized clinical trials (RCTs), and World Health Organization updates about the COVID-19. The inclusion criteria were the papers that described the effects of the most efficient types of herbal medicines on the containment of the COVID-19. Results: Analyzing nearly more than 40 medicinal plants, we found seven herbals (Myrtus communis, Zingiber officinale, Allium Sativum, Nigella Sativa, Glycyrrhiza glabra, and Thymus Vulgaris) that might have some positive effects on deferent stages of the COVID-19. Conclusion: Since some herbal medicines might help alleviate or relieve the symptoms of the COVID-19 or have other therapeutic effects, randomized controlled trials should be conducted to confirm these effects.

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Section: Myrtus Communis Lmentioning

confidence: 99%

Efficiency of Herbal Medicines in Containment of COVID-19

Sarahroodi

2021

Electron Physician

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“…2 Several organ failures are the end of long-term hyperglycemia. 3 Diabetes is the main cause of diseases and deaths in developing and developed countries, and the burden on health services is heavy. Among the different complications, those related to diabetes are the most serious and fatal diseases.…”

Section: Introductionmentioning

confidence: 99%

In vivo Performance of a Hydrogel of Tribulus terrestris in Alloxan induced Diabetic Rats

Singh¹,

Kumar²,

Yaduvanshi³

et al. 2023

Ind. J. Pharm. Edu. Res

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Background: Diabetes is one of the most important factors in chronic injuries. The gold standard for treating diabetic foot ulcers includes debridement of wounds, management of all infections, revascularization when indicated, and non-loading of ulcers. Traditionally, the aerial parts of Tribulus terrestris L. (Zygophyllaceae) are used in the folklore for the treatment of various kinds of wounds. Materials and Methods: Based on the evaluation of phytochemicals, a hydrogel of the hydroalcoholic and the aqueous of T. terrestris were prepared in this study. It was subjected to evaluation of the different parameters. The hydrogel of hydroalcoholic extract and aqueous extract was brown in color, uniform and non-irritant. It was further evaluated for pH, spreadability and viscosity. Furthermore, the in vivo performance of the hydrogel was evaluated in alloxan monohydrate induced diabetic rats. Results: In excision wound model and incision wound model topical application of 5% hydroalcoholic extract hydrogel in diabetic Wistar albino rat showed remarkable repair effects. It significantly (***p<0.001) enhanced the rate of % wound contraction. It also exhibited significant (***p<0.001) content of hydroxyproline and extremely high tensile strength (***p<0.001) as compared to the diabetic control group. It may be due to enhanced collagen synthesis. The histopathological examination of 5% hydroalcoholic extract hydrogel of T. terrestris L. treated rats showed skin architecture which was comparable to the normal group. The diabetes-induced group rats' wounds failed to heal even 25 days post the infliction of the wounds. Our model precisely reproduced the pathophysiology of diabetic ulcers and can serve as a valid alternative model for diabetic foot ulcer and to explore new therapies. Conclusion: The results strongly support that the hydrogel of the hydroalcoholic extract of T. terrestris seems to be a novel and promising biomaterial used for wound healing applications.

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Misuse of traditional knowledge can compromise research, practice and policy: It doesn’t need to, we just need to take it more seriously

Wardle¹

2022

Advances in Integrative Medicine

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Management of a diabetic foot ulcer with a Myrtle (M. communis) gel based on Persian medicine: A case report

Cited by 7 publications

References 17 publications

Efficiency of Herbal Medicines in Containment of COVID-19

Efficiency of Herbal Medicines in Containment of COVID-19

In vivo Performance of a Hydrogel of Tribulus terrestris in Alloxan induced Diabetic Rats

Misuse of traditional knowledge can compromise research, practice and policy: It doesn’t need to, we just need to take it more seriously

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