Management guidelines for acute infective diarrhoea / gastroenteritis in infants

Wittenberg, Dankwart Friedrich

doi:10.7196/samj.5243

Cited by 19 publications

(17 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this way, complications and risks can be avoided, such as serious dehydration, electrolyte disturbances, and altered nutrient absorption and digestion with worsening nutritional status. Such complications can lead to increased requirements for enteral or parenteral rehydration and nutrition, and hospitalization [1,2,17]. Thus, treatments such as gelatin tannate, with the potential to enhance efficacy of oral rehydration therapy and obviate the need for enteral or parenteral intervention, clearly warrant detailed investigation.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Gelatin Tannate Against Symptoms of Acute Diarrhea in Pediatric Patients

et al. 2017

View full text Add to dashboard Cite

BackgroundAcute diarrhea is the second most common cause of morbidity and mortality worldwide, especially in children aged ≤3 years. Some drugs (e.g., the mucoprotector gelatin tannate) plus a reduced osmolality oral rehydration solution (ORS) may effectively reduce symptom duration and severity. The current trial was therefore designed to assess the efficacy and safety of gelatin tannate in pediatric patients with acute diarrhea.Material/MethodsThis was a randomized, controlled, double-blind, parallel-group, single-center study comparing gelatin tannate plus ORS (103 patients) with ORS plus placebo (100 patients) in children aged 3 months to 12 years with infectious or noninfectious acute diarrhea. Details about stool consistency and total time to resolution of diarrhea comprised the primary study endpoints. Secondary study endpoints included symptoms of diarrhea at 12, 24, 36, 48, and 72 hours after the first dose of study medication.ResultsFrom 12 hours onwards, the incidence of watery stools was significantly lower in the gelatin tannate group than in the ORS group (at 12 hours: 59.2% vs. 77.0%; p=0.01). The same was true for stool frequency (at 12 hours: mean 2 vs. 3 stool productions in the previous 12 hours; p<0.01). At all timepoints during the study, the proportion of patients with Stool Decrease Index improvement was significantly greater (p<0.01) in the gelatin tannate group than in the placebo group (at 12 hours: 66.6% vs. 33.3%; p<0.01).ConclusionsGelatin tannate plus ORS is an effective and safe option for the treatment of acute diarrhea in children. Significant symptom relief is evident 12 hours after starting treatment.

show abstract

Section: Discussionmentioning

confidence: 99%

Evaluation of Gelatin Tannate Against Symptoms of Acute Diarrhea in Pediatric Patients

et al. 2017

View full text Add to dashboard Cite

show abstract

“…12 The relatively low incidence of the disease in newborns is the result of several factors: breastfeeding and the universal practice of giving birth at home in rural villages, and improvements in social and educational standards and medical care in advanced countries. 13,14 Otherwise, newborns are particularly susceptible to enteric infections in early life, due to reduced local and systemic immune response, absence of an adequate intestinal flora, and reduced gastric acidity. In the newborn, the protective role of gastric motility and of the intestinal mucus is still uncertain.…”

Section: Introduction and Epidemiologymentioning

confidence: 99%

Management strategies in the treatment of neonatal and pediatric gastroenteritis

Ciccarelli¹,

Stolfi²,

Caramia³

2013

IDR

View full text Add to dashboard Cite

Acute gastroenteritis, characterized by the onset of diarrhea with or without vomiting, continues to be a major cause of morbidity and mortality in children in mostly resource-constrained nations. Although generally a mild and self-limiting disease, gastroenteritis is one of the most common causes of hospitalization and is associated with a substantial disease burden. Worldwide, up to 40% of children aged less than 5 years with diarrhea are hospitalized with rotavirus. Also, some microorganisms have been found predominantly in resource-constrained nations, including Shigella spp, Vibrio cholerae, and the protozoan infections. Prevention remains essential, and the rotavirus vaccines have demonstrated good safety and efficacy profiles in large clinical trials. Because dehydration is the major complication associated with gastroenteritis, appropriate fluid management (oral or intravenous) is an effective and safe strategy for rehydration. Continuation of breastfeeding is strongly recommended. New treatments such as antiemetics (ondansetron), some antidiarrheal agents (racecadotril), and chemotherapeutic agents are often proposed, but not yet universally recommended. Probiotics, also known as “food supplement,” seem to improve intestinal microbial balance, reducing the duration and the severity of acute infectious diarrhea. The European Society for Paediatric Gastroenterology, Hepatology and Nutrition and the European Society of Paediatric Infectious Diseases guidelines make a stronger recommendation for the use of probiotics for the management of acute gastroenteritis, particularly those with documented efficacy such as Lactobacillus rhamnosus GG, Lactobacillus reuteri, and Saccharomyces boulardii. To date, the management of acute gastroenteritis has been based on the option of “doing the least”: oral rehydration-solution administration, early refeeding, no testing, no unnecessary drugs.

show abstract

“…(6) Preventive elements included Rota and measles vaccination, promotion of early and exclusive breast-feeding with vitamin A supplementation, promotion of hand washing with soap, improvement of water supply including treatment and safe storage of household water, and promotion of community-wide sanitation. (7) Supplementations with zinc and probiotics have been shown to reduce severity and duration of diarrhea; however evidence does not support the use of antisecretary, antimotility and binding agents.…”

Section: Int J Adv Res 4(12) 416-421mentioning

confidence: 99%

Comparative Study of Efficiency of Zinc Integration in Acute Diarrhea.

Dabour¹,

Esmail²,

Assar³

et al. 2016

IJAR

View full text Add to dashboard Cite

Management guidelines for acute infective diarrhoea / gastroenteritis in infants

Cited by 19 publications

References 36 publications

Evaluation of Gelatin Tannate Against Symptoms of Acute Diarrhea in Pediatric Patients

Evaluation of Gelatin Tannate Against Symptoms of Acute Diarrhea in Pediatric Patients

Management strategies in the treatment of neonatal and pediatric gastroenteritis

Comparative Study of Efficiency of Zinc Integration in Acute Diarrhea.

Contact Info

Product

Resources

About