Management for squamous cell carcinoma of the nasal cavity and ethmoid sinus: A single institution experience

Homma, Akihiro; Nakamaru, Yuji; Sakashita, Tetsuya; Onimaru, Rikiya; Terasaka, Shunsuke; Tsuchiya, Kunihiko; Yoshida, Daisuke; Yasuda, Kôichi; Hatakeyama, Hyōe; Furusawa, Jun; Mizumachi, Takatsugu; Kano, Satoshi; Shirato, Hiroki; Fukuda, Satoshi

doi:10.1016/j.anl.2015.02.005

Cited by 9 publications

(12 citation statements)

References 12 publications

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“…All 44 studies included information on survival data, with 35 (n = 1903) reporting on 5-year OS. 4,6-8,10,11,14-18,23-55 The weighted mean overall 5-year OS in this review was 54.5% (range, 18%-75%). Five-year OS data available on all patients undergoing surgery, open and endoscopic surgery, no surgery, radiation, surgery alone, surgery and RT, CT, and CT and RT are reported in Table 3 .…”

Section: Resultsmentioning

confidence: 72%

Prognostic Factors and Outcomes of De Novo Sinonasal Squamous Cell Carcinoma: A Systematic Review and Meta‐analysis

Nguyen¹,

Risbud²,

Birkenbeuel³

et al. 2021

Otolaryngol.--head neck surg.

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Objective To review overall survival (OS), recurrence patterns, and prognostic factors of de novo sinonasal squamous cell carcinoma (DN-SCC). Data Sources PubMed, Scopus, OVID Medline, and Cochrane databases from 2006 to December 23, 2020. Review Methods The study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Articles were required to report either recurrence patterns or survival outcomes of adults with DN-SCC. Case reports, books, reviews, meta-analyses, and database studies were all excluded. Results Forty-one studies reported on survival or recurrence outcomes. The aggregate 5-year OS was 54.5% (range, 18%-75%) from 35 studies (n = 1903). Patients undergoing open surgery were more likely to receive radiation therapy and present at an advanced stage compared to those receiving endoscopic surgery (all P < .001). Advanced T stage, presence of cervical nodal metastases, maxillary sinus primary site, and negative human papillomavirus (HPV) status were all correlated with significantly worse 5-year OS. Direct meta-analysis of 8 studies demonstrated patients with surgery were more likely to be alive at 5 years compared to those who did not receive surgery (odds ratio, 2.26; 95% CI, 1.48-3.47; P < .001). Recurrence was reported in 628 of 1471 patients from 26 studies (42.7%) with an aggregate 5-year locoregional control rate of 67.1% (range, 50.4%-93.3%). Conclusion This systematic review and meta-analysis suggests that the 5-year OS rate for DN-SCC may approach 54.5% and recurrence rate approaches 42.7%. In addition, various tumor characteristics including advanced T stage, positive nodal status, maxillary sinus origin, and negative HPV status are all associated with decreased survival.

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Section: Resultsmentioning

confidence: 72%

Prognostic Factors and Outcomes of De Novo Sinonasal Squamous Cell Carcinoma: A Systematic Review and Meta‐analysis

Nguyen¹,

Risbud²,

Birkenbeuel³

et al. 2021

Otolaryngol.--head neck surg.

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“…In contrast to our study which did not include any T4 patients, Kilic et al included patients with clinical stage T4a (22%) and T4b (5.9%). As previously stated, we selected patients in strict accordance with our institutional policy [11] . Therefore, eligible patients for surgery were patients with T1-2 disease and slightly resected T3-T4a disease.…”

Section: Discussionmentioning

confidence: 99%

“…RADPLAT consisted of super selective intraarterial infusions of cisplatin (100-120 mg/m 2 /week, 4 times) with simultaneous intravenous infusions of thiosulfate to neutralize cisplatin toxicity and conventional radiotherapy (65-70Gy) [10] . IV-CRT or RADPLAT is recommended for the treatment of unresectable tumors (T4b) or patients who refuse surgery [11] .…”

Section: Selection Criteria For Endoscopic Endonasal Surgerymentioning

confidence: 99%

The role of endoscopic resection for selected patients with sinonasal squamous cell carcinoma

et al. 2021

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Despite of rapid advances in endoscopic surgery, the gold standard for sinonasal squamous cell carcinoma (SNSCC) surgery has remained the open approach with en-block resection due to the aggressive nature of SNSCC, including frequent recurrence and high mortality rate. For that reason, few studies have focused on SNSCC treated by endoscopic surgery alone. The objective of this study was to evaluate the usefulness of endoscopic surgery for patients with SNSCC. Methods: A retrospective analysis was performed for 15 consecutive SNSCC patients who underwent endoscopic surgery without an open approach. We carefully selected patients whose tumor attachment sites could be fully visualized and completely resected through an endonasal approach. Results: Of the fifteen patients, 4 patients (27%) were diagnosed with T1, 7 (47%) with T2, 4 (27%) with T3, and no patients with T4a or T4b disease. Four of the 15 (27%) patients showed positive surgical margins. The 5-yr overall survival, disease-specific survival, and local control rate was 72.4%, 79.6%, and 92.9%, respectively. The 5-yr disease-specific survival for T1, T2, and T3 disease was 100% and 75% and 75%, respectively. Patients with negative surgical margins had a better disease-specific survival rate than did those with positive surgical margins (p = 0.0253). Conclusion: Endoscopic surgery for patients with SNSCC appears to afford an effective method in selected cases. The achievement of negative surgical margins with a good view of the tumor attachment site was considered to be critical to the management of SNSCC.

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“…Thus, there have been few reports on the treatment outcomes of patients with SN-SCC other than those occurring in the maxillary sinus. Homma et al reported 25 consecutive patients with SCC of the nasal cavity and the ethmoid sinus treated between 2000 and 2012 [29] . Four patients were diagnosed with T1, 3 with T2, 4 with T3, 7 with T4a, and 7 with T4b disease.…”

Section: Treatment Outcomes For Ees Compared To Other Approaches For mentioning

confidence: 99%

“…Although, the overall incidence of SN-SCC has been steadily and significantly declining in the past 30 years, survival has not significantly improved in this period. Unfortunately, as can be seen from the above reports, the 5-year OS for SN-SCC ranges from 40 to 53%, and this figure has not changed over the last three decades, despite advances in imaging modalities and treatment regimens [29][30][31] .…”

Section: Treatment Outcomes For Ees Compared To Other Approaches For mentioning

confidence: 99%

Endonasal endoscopic surgery for sinonasal squamous cell carcinoma from an oncological perspective

et al. 2021

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Management for squamous cell carcinoma of the nasal cavity and ethmoid sinus: A single institution experience

Cited by 9 publications

References 12 publications

Prognostic Factors and Outcomes of De Novo Sinonasal Squamous Cell Carcinoma: A Systematic Review and Meta‐analysis

Prognostic Factors and Outcomes of De Novo Sinonasal Squamous Cell Carcinoma: A Systematic Review and Meta‐analysis

The role of endoscopic resection for selected patients with sinonasal squamous cell carcinoma

Endonasal endoscopic surgery for sinonasal squamous cell carcinoma from an oncological perspective

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