Management and Treatment of COVID-19: The Chinese Experience

Abstract

With more than 1,800,000 cases and 110,000 deaths globally, COVID-19 is one of worst infectious disease outbreaks in history. This paper provides a critical review of the available evidence regarding the lessons learned from the Chinese experience with COVID-19 prevention and management. The steps that have led to a near disappearance of new cases in China included rapid sequencing of the virus to establish testing kits, which allowed tracking of infected persons in and out of Wuhan. In addition, aggressive quarantine measures included the R ESUM EAvec plus de 1 800 000 cas et 110 000 d ecès dans le monde, la COVID-19 est l'une des pires eclosions de maladies infectieuses de l'histoire. Ce document pr esente un examen critique des constats disponibles concernant les leçons tir ees de l'exp erience chinoise en matière de pr evention et de gestion de la COVID-19. Les mesures qui ont conduit à la quasi-disparition des nouveaux cas en Chine comprenaient le s equençage rapide du virus pour etablir des trousses de tests, ce qui a permis de suivre les personnes infect ees à l'int erieur et à Since mid-December 2019, there has been a worldwide outbreak of coronavirus disease (COVID)e19, caused by SARS-CoV-2 (formerly 2019-nCoV or HCoV-19) and first detected in Wuhan, China. The incubation period is 1-14 days (mean 5-6 days) in most cases, but can be as long as 24 days. 1 The most commonly seen characteristics of COVID-19 are fever, cough, and abnormal chest computed tomography. 2,3 At present, the Chinese chrysanthemum bat is thought to be the origin of SARS-CoV-2, based on sequence homology of 96% between SARS-CoV-2 and Bat-CoV-RaTG13. 4,5 The pangolin has been proposed as an intermediate host, but this has not been confirmed. 6,7 Human-to-human transmission of SARS-CoV-2 occurs mainly via respiratory droplets, 1 direct contact, 1 asymptomatic transmission, 8,9 and intrafamilial transmission. 3 SARS-CoV-2 can affect any demographic, including senior citizens, children, and pregnant women. 3,10 According to the World Health Organisation (WHO),

Exosomes Derived from Bone Marrow Mesenchymal Stem Cells as Treatment for Severe COVID-19

“…rates are estimated as high as 60%-79% in patients requiring noninvasive oxygen support [25,26], our preliminary findings suggest that ExoFlo may be a preventative measure against progression to invasive oxygen support and mechanical ventilation, though further studies with randomized controlled trials (RCTs) are warranted to prove efficacy. In total, 75% of cohort B (16/20) recovered, as evidenced by discharge from the hospital, demonstrating a profound reversal of disease progression and suggesting that the optimal time to administer ExoFlo is early in the cytokine storm.…”

“…This study demonstrated profound reversal of hypoxia, immune reconstitution, and downregulation of cytokine storm in patients hospitalized with severe COVID-19 following a single intravenous dose of bone marrow derived exosomes, with no adverse effects attributable to the treatment. Ultimately, the application of bone-marrow-derived exosomes may extend far beyond SARS-CoV-2 ARDS or COVID-19, spanning a myriad of inflammatory disease states, including classic ARDS, chronic obstructive pulmonary disease, sepsis, autoimmune disease, and cancer [26][27][28][29][30][31][32][33][34]. Further clinical studies are warranted to investigate safety and efficacy.…”

Anxiety and Depression Symptoms of Patients in Fangcang Shelter Hospital During the COVID-19 Outbreak in China: a Web-Based Cross-Sectional Study

“…Based on P < 0.10 as screening covariates, family member con rmed COVID-19(χ 2 = 3.334, P = 0.068), number of current physical symptoms(χ 2 = 18.760, P < 0.001), symptoms change after hospitalization(χ 2 = 5.952, P = 0.051), poor sleep quality(χ 2 = 5.449, P = 0.020)were related factors of anxiety symptom, please refer to Table 1; Gender(χ 2 = 17.169, P < 0.001), education level(χ 2 = 5.264, P = 0.072), smoking history(χ 2 = 4.039, P = 0.044), drinking history(χ 2 = 3.024 P = 0.082), family member con rmed COVID-19(χ 2 = 4.707, P = 0.030), number of current physical symptoms(χ 2 = 14.812, P < 0.001), Symptoms change after hospitalization(χ 2 = 4.696 P = 0.096), Poor sleep quality(χ 2 = 4.696, P = 0.046) were the related factors of depression symptom, please refer to Table 1. (7,12). By using Spearman correlation tests, PSQI scores were signi cant positively associate with SAS scores(r = 0.177, P = 0.002)) and SDS scores(r = 0.327, P 0.001).…”

“…we know very little about the psychological effects of patients with COVID-19. [11] To control the source of infection and save lives, China adopted strategies and tactics including establishment of Fangcang shelter hospitals in Hubei Province [12]. Fangcang shelter hospital is a novel public health concept which was developed and used for the rst time in China to tackle the coronavirus disease2019 (COVID-19) outbreak [13].…”

Efficiency of Online Course of Medical Statistics in Nanjing Medical University During the COVID-19 Epidemic

“…[1][2][3]The COVID-19 pandemic has led to the closure of schools in many countries. [4,5] University as a secondary teaching platform, and QQ group as an online Q&A platform.…”