Management and outcomes of neonates with down syndrome admitted to neonatal units

Mann, Jake; Statnikov, E; Modi, Neena; Johnson, Nik; Springett, A; Morris, Joan K.

doi:10.1002/bdra.23513

Cited by 11 publications

(10 citation statements)

References 17 publications

(18 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Home oxygen therapy was prescribed for 16% of NICU infants with T21 and only 3% of controls. A similar finding was published in a case-control study of infants in over 100 neonatal units, in which 11% of infants with T21 and 3% of control infants were prescribed home oxygen ( 3 ).…”

Section: Discussionsupporting

confidence: 79%

“…Figure 3 shows that the number of hypoxemia events was significantly higher for infants with T21 compared to controls during the whole NICU stay, and the difference was even greater in the final NICU week. Through the entire stay, infants with T21 had a median of 10 ( 7 , 23 ) events/day versus 7 ( 3 , 13 ) events/day for control infants, p=0.0064. In the final week before discharge home, there was an even greater difference in number of hypoxemia events in infants with versus controls (median 13 ( 7 , 24 ) events/day versus 7 ( 3 , 14 ), p=0.0008).…”

Section: Resultsmentioning

confidence: 97%

“…Through the entire stay, infants with T21 had a median of 10 ( 7 , 23 ) events/day versus 7 ( 3 , 13 ) events/day for control infants, p=0.0064. In the final week before discharge home, there was an even greater difference in number of hypoxemia events in infants with versus controls (median 13 ( 7 , 24 ) events/day versus 7 ( 3 , 14 ), p=0.0008).…”

Section: Resultsmentioning

confidence: 97%

See 2 more Smart Citations

Hypoxemia in infants with trisomy 21 in the neonatal intensive care unit

et al. 2021

View full text Add to dashboard Cite

Objective Newborns with Trisomy 21 (T21) often require NICU hospitalization. Oxygen desaturations are frequently observed in these infants, even in the absence of congenital heart defects (CHD). We hypothesized that T21 NICU patients have more hypoxemia than those without T21. Design All infants with T21 without significant CHD discharged home from the NICU between 2009–2018 were included (n=23). Controls were matched 20:1 for gestational age and length of stay. We compared daily severe hypoxemia events (SpO 2 <80% for ≥10 seconds) for the whole NICU stay and the pre-discharge week. Results Infants with T21 showed significantly more daily hypoxemia events during their entire NICU stay (median 10 versus 7, p=0.0064), and more so in their final week (13 versus 7, p=0.0008). Conclusion NICU patients with T21 without CHD experience more severe hypoxemia events than controls, particularly in the week before discharge. Whether this hypoxemia predicts or contributes to adverse outcomes is unknown.

show abstract

Section: Discussionsupporting

confidence: 79%

Section: Resultsmentioning

confidence: 97%

Section: Resultsmentioning

confidence: 97%

See 1 more Smart Citation

Hypoxemia in infants with trisomy 21 in the neonatal intensive care unit

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Our patients experienced a high rate of neonatal complications with 70.6% requiring NICU stay as new-borns, indicating the importance of appropriate medical readiness and intervention from birth to discharge [4,22]. Infants required oxygen in over 60% of admits and 60% required phototherapy.…”

Section: Neonatal Complicationsmentioning

confidence: 88%

Pediatric Comorbidities and Medical Complications Identified in Children with Down Syndrome

Hickey¹,

Wolter‐Warmerdam²,

Hickey³

et al. 2017

J Down Syndr Chr Abnorm

View full text Add to dashboard Cite

Objective: Children with Down syndrome (DS) have an increased risk of neonatal complications and comorbidities compared to the general population; however, the incidence, optimal screening intervals and outcomes in this population are uncertain. The purpose of this study is to phenotypically define this population of children with DS using a large multi-age and ethnic sample and current American Academy of Pediatrics (AAP) Guidelines testing practices.Method: This is a retrospective review of a large cohort of 1,108 children with DS (male=602; mean age at initial contact: 5.72 years, SD ± 5.51) who received care at the Sie Center for Down Syndrome (SCDS) at The Children's Hospital Colorado from 2011 and 2016. Clinical data were collected from a prospective patient clinic database. Clinical details were collected, which included demographics, prenatal and birth history and complications, comorbidities, procedures, treatment plans and outcomes.Results: Medical complications requiring admission to the neonatal intensive care unit were identified in 70.6% of children with DS. Frequent causes for these neonatal admissions included: Required oxygen (60.7%), feeding problem (48.2%), Respiratory Distress Syndrome (21.4%) and pulmonary hypertension (14.7%). Incidence of medical comorbidities in our population with DS included cardiac defects (64.3%), abnormal sleep study (71.1%), abnormal thyroid study (29.1%), pulmonary aspiration (12.2%), celiac disease (5.0%) and pulmonary arterial hypertension (28.3%). Conclusion:Clinical data provides results from one of the largest investigations at a single pediatric hospital for children and young adults with DS in the US. This study describes the comorbidities affecting individuals with DS more accurately by applying AAP guidelines in studying a larger population than previously defined. This result improves our understanding of the incidence and identification of medical conditions in children with DS and reinforces recommendations on medical care screening for individuals with DS.

show abstract

“…While much has been published about prenatal rates of Down syndrome detection with various screening test and termination rates following a prenatal diagnosis, less is known about the incidence of a prenatal diagnosis in live born infants with Down syndrome or their neonatal outcomes (de Graaf, Buckley, & Skotko, 2016; Hurford, Hawkins, Hudgins, & Taylor, 2013). A recent study from England estimated that 46% of all neonates with Down syndrome are requiring intensive care as neonates with prematurity being a significant contributing factor (Mann et al, 2016). What is not yet understood is what medical and/or surgical issues are driving this need for advanced care.…”

Section: Introductionmentioning

confidence: 99%

Neonatal complications of Down syndrome and factors necessitating intensive care

Seither

Tabbah

Tadesse

et al. 2020

American J of Med Genetics Pt A

View full text Add to dashboard Cite

Limited knowledge exists about how frequently newborns with Down syndrome receive a prenatal diagnosis, require intensive care, and what surgical and medical factors are contributory. A retrospective cohort study was performed for patients with a diagnosis of Down syndrome born in 2013 and 2014 who sought care at Cincinnati Children's Hospital Medical Center during the first year of life. Data were extracted from the electronic medical record through the first year of life including need for intensive care as a newborn, prenatal diagnosis, and medical and surgical complications. Of the 129 patients in the study, 65% required intensive care as newborns. The presence of a structural abnormality that required surgical correction in the neonatal period and certain types of congenital heart disease not requiring surgical intervention in the neonatal period were positively associated with the need for intensive care. A minority of infants, 8%, had a confirmed prenatal diagnosis. A majority of newborns with Down syndrome required intensive care following birth while a minority had any concern for the diagnosis prenatally. Improving prenatal diagnostic rates would allow for better prenatal counseling and delivery planning, while targeting therapeutic interventions for this population is needed to improve outcomes.

show abstract

Management and outcomes of neonates with down syndrome admitted to neonatal units

Cited by 11 publications

References 17 publications

Hypoxemia in infants with trisomy 21 in the neonatal intensive care unit

Hypoxemia in infants with trisomy 21 in the neonatal intensive care unit

Pediatric Comorbidities and Medical Complications Identified in Children with Down Syndrome

Neonatal complications of Down syndrome and factors necessitating intensive care

Contact Info

Product

Resources

About