Management and Outcomes of Male Breast Cancer in Zaria, Nigeria

Ahmed, Aziza; Ukwenya, Yahaya; Abdullahi, Adamu; Muhammad, I.

doi:10.1155/2012/845143

Cited by 34 publications

(58 citation statements)

References 26 publications

(66 reference statements)

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“…5.6% patients presented with early gastric cancer. 12 In the present study the prevalence of gastric carcinoma was 4.46%, with male: female ratio of 3:1 and mean age of 50years.The prevalence of carcinoma stomach was more common in rural areas and poor socio economic status. Sixty percent of patients who consumed mixed diet suffered from carcinoma stomach.…”

Section: Resultssupporting

confidence: 45%

Clinicopathological study of carcinoma stomach over a period of 5 years

2017

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INTRODUCTIONGastric cancer is the most common cancer in the world accounting for 10% of all cancers. Over all rates in men are approximately double than the females.1 There is marked difference in the incidence between north and south India. Stomach cancer admission in south India was 4 times as frequent as in north India with a remarkable preponderance of males (20: 1) versus (7:1) in rest of India. In Kashmir the incidence is 3-6 times higher than rest of India.2 Endoscopy served as primary diagnostic procedure for diagnosing carcinoma stomach and has 80% accuracy the remaining 20% are evaluated by histopathological examination. METHODSA total of 115 gastrectomy specimens received in a 5 year period at a tertiary care center in the department of pathology was analyzed. The clinical details, demographic status, socio economic status, dietary habits, intake of alcohol, smoking including their blood groups were recorded. After fixing the specimen in 10% formal saline for 24 hours the gross appearance of the specimen was studied. The gross findings were recorded following Borrmann classification. The tissue blocks from the representative portions of the lesion along with the normal tissue were taken and routinely processed. The paraffin embedded blocks were cut into 2-4 microns thick ABSTRACT Background: Gastric cancer represents one of the most frequent neoplasias. Although its incidence decreased over the last few decades in industrialized countries, it still represents nowadays a major cause of death through cancer throughout the world. The purpose of this study was to identify clinicopathological parameters in gastric carcinoma. Methods: A total of 115 gastrectomy specimen received in 5 year period at a tertiary care center was analyzed. The clinical data was recorded. After fixing the specimen in 10% formal saline for 24 hours the gross appearance of the specimen was studied. The gross findings were recorded following Borrmann classification. The tissue blocks were routinely processed and stained with H&E stain. The results were tabulated. Results: The prevalence of gastric carcinoma was 4.46%, with male: female ratio of 3:1 and mean age of 50years.The prevalence of carcinoma stomach was more common in rural areas and poor socio economic status. Sixty percent of patients who consumed mixed diet suffered from carcinoma and 82.8% had history of intake of alcohol. Carcinoma stomach was more common in A blood group. The tumor was more common in pyloric antrum (73.04%). According to Borrmann classification type II tumour was the commonest (66.09%) of the lesions. Commonest histological pattern was adenocarcinoma; intestinal type (86.72%). Conclusions:The prevalence of carcinoma stomach in the present study was 4.46%. High prevalence of gastric carcinoma was seen in patients with history of smoking, intake of alcohol and consumption of mixed diet. Carcinoma stomach was more common in A blood group followed by B blood group. Adenocarcinoma of intestinal type was the commonest.

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Section: Resultssupporting

confidence: 45%

Clinicopathological study of carcinoma stomach over a period of 5 years

2017

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“…Peritoneal metastasis is usually associated with a poor prognosis in patients with GC[3]. It may be ineffectual for patients with peritoneal metastasis to merely undergo gastrectomy and regional lymphadenectomy.…”

Section: Discussionmentioning

confidence: 99%

“…Owing to the lack of symptomatology and specific diagnosis, the 5-year survival rate of the disease is unfortunately extremely low because patients generally have high-stage disease when diagnosed[2]. Among factors leading to a poor prognosis, peritoneal metastasis is an indispensable indicator[3,4]. A previous study[4] demonstrated that peritoneal metastasis, which accounted for 50% of deaths, is the most important contributing factor of mortality in patients with GC.…”

Section: Introductionmentioning

confidence: 99%

Use of the combination of the preoperative platelet-to-lymphocyte ratio and tumor characteristics to predict peritoneal metastasis in patients with gastric cancer

Chen

Mao

et al. 2017

PLoS ONE

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The aims of the present study were to evaluate the predictive value of the platelet-to-lymphocyte ratio for peritoneal metastasis in patients with gastric cancer and to construct an available preoperative prediction system for peritoneal metastasis. A total of 1080 patients with gastric cancer were enrolled in our study. The preoperative platelet-to-lymphocyte ratio and other serum markers and objective clinical tumor characteristics were evaluated by receiver operating characteristic curves. A logistic analysis was performed to determine the independent predictive indicators of peritoneal metastasis. A prediction system that included the independent predictive indicators was constructed and evaluated by receiver operating characteristic curves. Based on the receiver operating characteristic curves, the ideal platelet-to-lymphocyte ratio cutoff value to predict peritoneal metastasis was 131.00. The logistic analysis showed that the platelet-to-lymphocyte ratio was an independent indicator to predict peritoneal metastasis. The area under the receiver operating characteristic curve was 0.599. When integrating all independent indicators (i.e., platelet-to-lymphocyte ratio, invasion depth, lymphatic invasion, pathological type), the prediction system more reliably predicted peritoneal metastasis with a higher area under the receiver operating characteristic curve (0.769). The preoperative platelet-to-lymphocyte ratio was an indicator that could be used to predict peritoneal metastasis. Our prediction system could be a reliable instrument to discriminate between patients with gastric cancer with and those without peritoneal metastasis.

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“…Databases show that up to 93% of MBC cases are of advanced disease, and that distant metastases are observed in approximately 30% of these patients at the time of diagnosis (19,46). In the current study, the most frequent involvements were bone (n=12, 70.6%), lung (n=6, 35.3%), cranial field (n=3, 17.6%), brain (n=2, 11.8%), liver (n=2, 11.8%), pleura (n=1, 5.9%), and mesentery (n=1, 5.9%).…”

Section: Discussionmentioning

confidence: 99%

“…In the current study, the most frequent involvements were bone (n=12, 70.6%), lung (n=6, 35.3%), cranial field (n=3, 17.6%), brain (n=2, 11.8%), liver (n=2, 11.8%), pleura (n=1, 5.9%), and mesentery (n=1, 5.9%). There are other case series that reported different metastatic sites, among which were bones (48.78%), lungs (29.26%), liver (17.07%), spine (up to 30%), skin, and pleura (19,46).…”

Section: Discussionmentioning

confidence: 99%

The Management and Outcomes of Male Breast Cancer

Uslukaya

Gümüş

et al. 2016

J Breasth Health

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Objective: Due to a lack of sufficient data, the treatment protocols for male breast cancer are usually the same as those used for female breast cancer. The aim of the current study was to present our clinical experience with male breast cancer. Materials and Methods:The records of 37 patients who were treated for male breast cancer in our hospital between 2004 and 2014 were reviewed retrospectively. The data of patients were recorded and analyzed.Results: The mean age of the patients was 63.03±12.36 years. Thirty-three patients (89.2%) had invasive ductal carcinoma, two (5.4%) had ductal carcinoma in situ, and two had invasive lobular carcinoma (5.4%). The most common molecular subtype was luminal A (17 cases, 45.9%). Twentynine patients with male breast cancer underwent mastectomy and two underwent breast conserving surgery. Axillary lymph node dissection was performed in 25 patients. The most common surgical procedure was modified radical mastectomy. Distant metastases were present in 17 (45.9%) patients. Overall, the 5-year survival was 60%. The 5-year survival was 100% for those with stage 0-I disease, 87% for stage II, and 42% for stage III. The 3-year survival was 14% for stage IV. Conclusion:Patients with male breast cancer presented at an older age, a later stage, and with earlier metastasis. Early metastasis and death increases with increasing stage. Poor prognosis correlates with late admission. Data from different centers should be compiled and reviewed in order to determine a specific treatment protocol for male breast cancer; each paper published reveals new data.

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Management and Outcomes of Male Breast Cancer in Zaria, Nigeria

Cited by 34 publications

References 26 publications

Clinicopathological study of carcinoma stomach over a period of 5 years

Clinicopathological study of carcinoma stomach over a period of 5 years

Use of the combination of the preoperative platelet-to-lymphocyte ratio and tumor characteristics to predict peritoneal metastasis in patients with gastric cancer

The Management and Outcomes of Male Breast Cancer

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