Management and outcome of middle ear adenomatous neuroendocrine tumours: A systematic review

Engel, Michelle S D; Lans, Rik J. L. van der; Jansen, Jeroen C.; Leemans, C. René; Bloemena, Elisabeth; Lissenberg‐Witte, Birgit I.; Rijken, Johannes A.; Smit, Conrad F.; Hensen, Erik F.

doi:10.1016/j.oraloncology.2021.105465

Cited by 6 publications

(7 citation statements)

References 78 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, there is insufficient knowledge about the usage and effectiveness of petrosectomy in patients with middle ear tumors (particularly MeNETs). It is believed that MeNETs are low-grade malignant lesions with benign cell morphology that locally reoccur in 15-25 % of cases and metastasize in 7-9% of cases (mostly to cervical lymph nodes) [ 15 , 16 ]. The mean follow-up time published before 2018 was approximately 55 months.…”

Section: Discussionmentioning

confidence: 99%

“…Radiotherapy or chemotherapy should be used only in complicated cases with distant metastases. Further studies on its efficacy are needed [ 7 , 16 , 20 ].…”

Section: Discussionmentioning

confidence: 99%

“…Prevention of it is a matter of debate, but the patient was informed about the possible risks before each operation. In general, the reported overall five and 10-year survival rate in MeNET patients is positive, with 94% and 92%, respectively [ 16 ]. While our article highlights a rare occurrence of dura mater infiltration in the temporal fossa by the MeNET after complete tumor resection and a median follow-up time of 156 months (13 years), it is important to recognize that this is constrained by the limited scope of a single case.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Late Recurrence of a Rare Middle Ear Neuroendocrine Tumor With an Intracranial Extension to the Temporal Fossa: A Case Report

Kvaščevičius¹,

Lesinskas²,

Petroška³

et al. 2023

Cureus

View full text Add to dashboard Cite

We report a clinical case of an extremely rare neuroendocrine tumor of the right middle ear (MeNET) that recurred after 13 years with a local extension into the right temporal fossa. In the current medical literature, there are approximately 150 cases of MeNETs and even fewer cases with more than 10 years of follow-up, recurrence, and intracranial tumor progression. Therefore, we believe that this paper can make an important contribution to the existing and future knowledge about this disease. The purpose of this article is to present our experience in treating such a rare neoplasm in a 35-year-old woman. The patient initially complained of worsening hearing in her right ear over the past year. The final diagnosis was made based on the findings of computed tomography (CT), magnetic resonance imaging (MRI), and histological and immunohistochemical evaluation of excisional biopsies of the original and recurrent tumors. The primary tumor masses were removed with clear resection margins, and the ossicular chain was reconstructed. The patient has been monitored clinically and radiologically with temporal bone CTs every year and MRIs three times in general since then. A postoperative audiogram showed remaining mixed hearing loss in the right ear that eventually worsened as the tumor grew. Tumor recurrence and progression after 156 months (13 years) were seen on CT and MRI, requiring further treatment. After resection of the recurrent tumor, paresis of the right facial nerve developed, which was treated with dexamethasone. The surgical treatment caused the initial symptoms to disappear, but the facial nerve paresis persisted with mild functional improvement. The patient is not receiving adjuvant radiotherapy and is being monitored closely because the tumor may recur in the future.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Radiotherapy or chemotherapy should be used only in complicated cases with distant metastases. Further studies on its efficacy are needed [ 7 , 16 , 20 ].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Late Recurrence of a Rare Middle Ear Neuroendocrine Tumor With an Intracranial Extension to the Temporal Fossa: A Case Report

Kvaščevičius¹,

Lesinskas²,

Petroška³

et al. 2023

Cureus

View full text Add to dashboard Cite

show abstract

“…Head and neck NEN are a rare and diverse group of tumors. NEN in the middle ear are particularly uncommon, as epithelial cells with neuroendocrine features typically do not reside there [ 4 ]. The gastrointestinal tract and lungs are the most frequent locations for NEN [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

“…The gastrointestinal tract and lungs are the most frequent locations for NEN [ 3 ]. Previous studies have proposed that middle-ear neuroendocrine tumors originate from neural crest cells [ 4 ]. The first reported case of a middle ear adenoma, referred to as an “adenomatous tumor,” was documented by Derlacki and Barney in 1976.…”

Section: Introductionmentioning

confidence: 99%

Middle Ear Neuroendocrine Tumor Mimicking As Chronic Otitis Media

Sukumaran¹,

Ong²,

Ping³

et al. 2023

Cureus

View full text Add to dashboard Cite

Neuroendocrine neoplasms (NEN) of the head and neck are a rare and diverse group of tumors. Here, we report a case of a 40-year-old man presenting with symptoms resembling chronic left otitis media, including left ear otorrhea, otalgia, and reduced hearing. Otoscopic examination revealed a whitish mass located behind the tympanic membrane. The patient underwent examination under anesthesia and left cortical mastoidectomy, and a histopathological examination of the middle ear biopsy indicated the presence of an epithelial tumor with neuroendocrine differentiation, suggestive of middle ear adenoma. A staging CT scan performed three months after the mastoidectomy showed a hypodensity in the middle ear cavity, with no significant bony erosion, which could potentially indicate a residual or recurrent tumor. Consequently, a radical mastoidectomy was performed. The histopathological examination confirmed the presence of middle ear adenoma with neuroendocrine differentiation.

show abstract

A carcinoid tumor of the middle ear masquerading as a glomus tympanicum presenting with temporal lobe hemorrhage in a 70-year-old woman: Case report and review of the literature

Chang¹,

Silva²,

Torres³

et al. 2022

Neurochirurgie

View full text Add to dashboard Cite

Management and outcome of middle ear adenomatous neuroendocrine tumours: A systematic review

Cited by 6 publications

References 78 publications

Late Recurrence of a Rare Middle Ear Neuroendocrine Tumor With an Intracranial Extension to the Temporal Fossa: A Case Report

Late Recurrence of a Rare Middle Ear Neuroendocrine Tumor With an Intracranial Extension to the Temporal Fossa: A Case Report

Middle Ear Neuroendocrine Tumor Mimicking As Chronic Otitis Media

A carcinoid tumor of the middle ear masquerading as a glomus tympanicum presenting with temporal lobe hemorrhage in a 70-year-old woman: Case report and review of the literature

Contact Info

Product

Resources

About