Management and outcome of metastatic melanoma during pregnancy

Pagès, Cécile; Robert, Caroline; Thomas, Luc; Maubec, Ève; Sassolas, B.; Granel‐Brocard, F.; Chevreau, Christine; Raucourt, Sixtine de; Leccia, Marie‐Thérèse; Fichet, D; Khammari, Amir; Boitier, F.; Stoebner, P; Dalac, S.; Célérier, P.; Aubin, F.; Viguier, Manuelle

doi:10.1111/j.1365-2133.2009.09240.x

Cited by 59 publications

(24 citation statements)

References 31 publications

(46 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These latter studies used appropriate control groups and considered stage of disease and important prognostic factors such as tumor thickness and location. Even those rare reports of stage III and IV melanoma in pregnant women who undergo therapy did not show a difference in survival when compared with nonpregnant patients (Pagès et al, 2010). However, some of the more recent large cohort studies do not separate MM that is diagnosed during pregnancy from MM that is diagnosed during what the authors view as the pre- and post-partum period.…”

Section: Introductionmentioning

confidence: 91%

Prognosis for women diagnosed with melanoma during, before, or after pregnancy: Weighing the evidence

Todd

Driscoll

2017

International Journal of Women's Dermatology

View full text Add to dashboard Cite

Approximately one third of women who are diagnosed with malignant melanoma are of childbearing age. Therefore, it is not surprising that some studies have found malignant melanoma to be one of the most common malignancies diagnosed in pregnant women. The impact of pregnancy-related hormonal changes on melanoma development and progression remains controversial. Women undergo immunologic changes during pregnancy that may decrease tumor surveillance. Additionally, hormone receptors are found on some melanomas. Unfortunately, many of the past and even recent studies that have been published and are reviewed herein did not uniformly use appropriate control groups, account for confounding covariates, or employ appropriate statistical analysis, which makes it difficult to rely on the conclusions they reach. However, a review of the better controlled and preponderant studies demonstrates that pregnancy-associated melanomas are not associated with a poorer prognosis.

show abstract

Section: Introductionmentioning

confidence: 91%

Prognosis for women diagnosed with melanoma during, before, or after pregnancy: Weighing the evidence

Todd

Driscoll

2017

International Journal of Women's Dermatology

View full text Add to dashboard Cite

show abstract

“…The European Society for Medical Oncology currently recommends the same treatment standards for a patient diagnosed with MM, regardless of the pregnancy status [15]. Preventive measures including frequent dermatological examinations and prompt biopsy of any suspicious lesion, particularly for high-risk women, remains the most important method of treatment for women in pregnancy.…”

Section: Treatment Optionsmentioning

confidence: 99%

Melanoma in pregnancy – where we are?

Iżycki¹,

Kerrigan²,

Kaźmierczak³

2013

View full text Add to dashboard Cite

SummaryWith rising rates of melanoma and women bearing children at older ages, the incidence of malignant melanoma in pregnancy will continue to increase. Initial reports in the 1950s portrayed a belief of the medical community that pregnant women who were diagnosed with malignant melanoma suffered a poorer prognosis. Numerous studies since then have shown that this is not the case, and pregnancy has not been shown to have a negative impact on the prognosis of malignant melanoma. Various mechanisms of hormones affecting malignant melanoma have been proposed, although nothing conclusive has been found. And although very rare, fetal metastasis is a serious risk and needs to be kept under consideration. Continual research and period reviews are necessary to best understand any effects of pregnancy on malignant melanoma, guide research, and maximize patient care.Key words: melanoma malignum, pregnancy. StreszczenieCzerniak złośliwy stanowi 25% wszystkich nowotworów diagnozowanych w czasie ciąży. Wstępne doniesienia z początku lat 50. poprzedniego stulecia postulowały gorsze rokowanie w zakresie całkowitych przeżyć oraz okresu wolnego od choroby w przypadku kobiet w ciąży ze zdiagnozowanym czerniakiem. Sugerowano istnienie mechanizmu wieloczynnikowej immunosupresji promującej progresję nowotworu oraz wpływ hormonów płciowych na wzrost proliferacyjnej aktywności komórek czerniaka. Jednak kolejne dane literaturowe wykluczyły możliwość istnienia negatywnej korelacji pomiędzy ciążą a dynamiką rozwoju i stopniem zaawansowania klinicznego czerniaka. Sprzeczne doniesienia naukowe, a także rozbieżne wnioski dotyczące ryzyka przerzutów czerniaka złośliwego do płodu narzucają konieczność kontynuowania badań klinicznych w celu lepszego zrozumienia wpływu ciąży na rozwój czerniaka.Słowa kluczowe: czerniak złośliwy, ciąża.

show abstract

“…50 However, the use of multiple, consecutive CT studies with direct exposure to the fetus has the potential to exceed threshold levels. In the setting of repeat exposures, consultation with a medical physicist is necessary to verify …”

Section: X-raymentioning

confidence: 99%

Cancer in Pregnancy

Backes

Moorehead

Nelin

2011

Clinical Obstetrics &Amp; Gynecology

View full text Add to dashboard Cite

Cancer during pregnancy represents a potential conflict between optimal maternal treatment and fetal development. Traditionally, clinicians operated under the assumption that cancer treatment during pregnancy is incompatible with normal fetal development. However, recent evidence suggests that many diagnostic and treatment modalities cause little or no harm to the developing fetus. As such, both maternal and neonatal interests should be considered when developing management strategies for pregnant cancer patients. In this review, we will discuss issues related to fetal and neonatal health associated with conventional diagnostic and treatment approaches in the care of pregnant women with cancer. In addition, we offer recommendations on strategies to maximize fetal outcomes in pregnancies complicated by cancer.

show abstract

Management and outcome of metastatic melanoma during pregnancy

Cited by 59 publications

References 31 publications

Prognosis for women diagnosed with melanoma during, before, or after pregnancy: Weighing the evidence

Prognosis for women diagnosed with melanoma during, before, or after pregnancy: Weighing the evidence

Melanoma in pregnancy – where we are?

Cancer in Pregnancy

Contact Info

Product

Resources

About