Management and Outcome of Gallbladder Carcinoma with Obstructive Jaundice: a Retrospective Study from Eastern Nepal

Pandit, Narendra; Yadav, Tek Narayan; Awale, Laligen; Mahat, Barun; Adhikary, Shailesh

doi:10.1007/s42399-020-00317-w

Cited by 3 publications

(1 citation statement)

References 17 publications

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“…Out of 30% of patients who underwent curative intent surgery, a median overall survival of 28 months after a median follow-up of 42 months (12–64 months) was reported. Our published study has shown, curative resection was possible in 9% (5/56) patients in GBC with obstructive jaundice 17 . Thus, with reference to our study, GBC with jaundice can no longer be considered as a contraindication to resection, albeit with a low rate.…”

Section: Discussionmentioning

confidence: 83%

Resectability and prognosis of gallbladder cancer: a cross-sectional study of 100 cases from a tertiary care centre of Eastern Nepal

Pandit

Neupane

Nalbo

et al. 2023

Annals of Medicine &Amp; Surgery

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Background: Gallbladder cancer (GBC) is the fifth most common neoplasm of the digestive tract and has an overall incidence of 3 per 100 000 people. Only 15–47% of the preoperatively known GBC are suitable for resection. The objective of the study was to investigate the resectability and prognosis of GBC patients. Materials and methods: It is a prospective observational study including all cases of primary cancers of the gallbladder in the Department of Surgical Gastroenterology at a tertiary care center over the period from January 2014 to December 2019. The primary endpoint was resectability and overall survival. Results: During the study period, 100 patients with GBC were reported. The mean age at the time of diagnosis was 52.5 years, with a female predominance (67%). The curative intent resection (radical cholecystectomy) was possible in 30 (30%) patients; while 18 (18%) required palliative surgical treatment. The overall survival of the entire group was 9 months; while those patients who underwent surgery with curative intent had a median overall survival of 28 months after a median follow-up of 42 months. Conclusion: This study found that only one-third of patients achieve radical surgery with curative intent. Overall, the prognosis of patients is poor with a median survival of less than a year due to the advanced stage disease. Multimodality treatment, screening ultrasound, and neo-/adjuvant therapy may improve survival.

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Section: Discussionmentioning

confidence: 83%

Resectability and prognosis of gallbladder cancer: a cross-sectional study of 100 cases from a tertiary care centre of Eastern Nepal

Pandit

Neupane

Nalbo

et al. 2023

Annals of Medicine &Amp; Surgery

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Impact of enhanced recovery pathway in 408 gallbladder cancer resections

Joshi

Thomas

Patkar

et al. 2022

HPB

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Resectability and Prognosis of Gallbladder Cancer: An experience of 100 cases from a tertiary care centre of Eastern Nepal

Pandit¹,

Neupane

Nalbo³

et al. 2022

Preprint

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Background Gallbladder cancer (GBC) is the fifth most common neoplasm of the digestive tract and has an overall incidence of 3 per 100000 people. Only 15%-47% of the preoperatively known GBC are suitable for resection. The objective of the study was to investigate the resectability and prognosis of GBC patients. Methods It is a prospective observational study including all cases of primary cancers of the gallbladder in the Department of Surgical Gastroenterology, B.P. Koirala Institute of Health Sciences (BPKIHS), over the period from January 2014 to December 2019. The primary endpoint was resectability and overall survival. Results During the study period, 100 patients with GBC were reported. The mean age at the time of diagnosis was 52.5 years, with a female predominance (67%). The curative intent resection (radical cholecystectomy) was possible in 30 (30%) patients; while 18 (18%) required palliative surgical treatment. The overall survival of the entire group was 9 months; while those patients who underwent surgery with curative intent had median overall survival of 28 months after median follow-up of 42 months. Conclusion This study found that only one-third of patients achieve radical surgery with curative intent. Overall, the prognosis of patients is poor with median survival of less than a year due to the advanced stage disease. Multimodality treatment, screening ultrasound, neo-/adjuvant therapy may improve survival.

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Management and Outcome of Gallbladder Carcinoma with Obstructive Jaundice: a Retrospective Study from Eastern Nepal

Cited by 3 publications

References 17 publications

Resectability and prognosis of gallbladder cancer: a cross-sectional study of 100 cases from a tertiary care centre of Eastern Nepal

Resectability and prognosis of gallbladder cancer: a cross-sectional study of 100 cases from a tertiary care centre of Eastern Nepal

Impact of enhanced recovery pathway in 408 gallbladder cancer resections

Resectability and Prognosis of Gallbladder Cancer: An experience of 100 cases from a tertiary care centre of Eastern Nepal

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