Management and outcome of cervical cancer diagnosed in pregnancy

Bigelow, Catherine A.; Horowitz, Neil S.; Goodman, Annekathryn; Growdon, Whitfield B.; Carmen, Marcela del; Kaimal, Anjali J

doi:10.1016/j.ajog.2016.10.034

Cited by 32 publications

(34 citation statements)

References 21 publications

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Section: Early and Long-term Outcomes Of Patients Diagnosed With Cervmentioning

confidence: 88%

“…As for the outcomes of these cases, it seems that the presence of the pregnancy does not influence significantly the early or long-term evolution 20,25 . An interesting study regarding the management and outcomes of cervical cancer patients diagnosed during pregnancy was published by Bigelow et al in the American Journal of Surgery in 2017 20 . The study included 28 such patients diagnosed and treated between 1997 and 2013 at Brigham and Women's Hospital and Massachusetts General Hospital who were matched 1:2 with contemporaneous, non-pregnant women with cervical cancer diagnosed within the same period of time.…”

Section: Early and Long-term Outcomes Of Patients Diagnosed With Cervmentioning

confidence: 88%

“…Moreover, the results reported so far in literature are rather conflicting, a standard therapeutic guideline not being available yet. While in the study conducted by Bigelow et al 20 (in which the majority of cases were diagnosed with FIGO stage IB lesions) completing the pregnancy and giving birth after the 36 th week did not influence the overall oncologic outcome of the patients, Xia et al reported opposite results: in their study it seemed that patients who decided to delay the oncologic treatment in order to prioritise the pregnancy reported a poorer overall survival 21 . However, the Chinese study included more advanced stages of the disease, most cases presenting tumors larger than 4 cm and a more aggressive biological subtype 21 .…”

Section: Locally Advanced Stagesmentioning

confidence: 90%

“…The study concluded that patients developing cervical cancer during pregnancy report similar outcomes with non-pregnant patients; however, a key factor is represented by the gestational age at diagnosis. As for the obstetrical outcomes, all women who continued the pregnancy delivered in the late preterm period without significant complication; the single parameter which was modified was the amount of blood loss, significantly higher in cases in which radical surgery was performed at the time of caesarean section 20 .…”

Section: Early and Long-term Outcomes Of Patients Diagnosed With Cervmentioning

confidence: 99%

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Management of cervical cancer during pregnancy– literature review

Bodog¹,

Bacalbaşa²,

Bălescu³

et al. 2018

Arch Balk Med Union

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Approche du cancer du col utérin pendant la grossesse-revue de la littérature Bien que l'incidence exacte des cas de cancer du col de l'utérus chez la femme enceinte ne soit pas connue, il s'agit sans aucun doute de la tumeur maligne gynécologique la plus courante diagnostiquée pendant la grossesse. L'association entre les deux entités ne semble pas influencer les résultats oncologiques. Cependant, la gestion de ces cas reste un véritable défi pour l'obstétricien et pour le gynéco-oncologue, se battre pour deux vies étant nécessaire. De plus, en raison de la rareté des cas, il n'existe pas de directives standard, la stratégie thérapeutique n'est influencée que par de petites séries de cas et des études observationnelles. Ceci est une revue de la littérature des options thérapeutiques actuelles disponibles pour la gestion de tels cas.

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Section: Early and Long-term Outcomes Of Patients Diagnosed With Cervmentioning

confidence: 88%

Section: Early and Long-term Outcomes Of Patients Diagnosed With Cervmentioning

confidence: 88%

Section: Locally Advanced Stagesmentioning

confidence: 90%

Section: Early and Long-term Outcomes Of Patients Diagnosed With Cervmentioning

confidence: 99%

See 2 more Smart Citations

Management of cervical cancer during pregnancy– literature review

Bodog¹,

Bacalbaşa²,

Bălescu³

et al. 2018

Arch Balk Med Union

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“…In a recent cohort study by Bigelow et al ( 28 ), a planned C-section was the preferred delivery method in cases of confirmed malignancy; vaginal deliveries performed on patients with microinvasive cancer or an unconfirmed diagnosis were not shown to affect disease progression and survival or cause perinatal complications. Despite these results, the authors concluded that elective C-section could be suggested as the optimal management, in view of potential local recurrence and distal metastasis ( 29 , 30 , 31 , 32 , 33 ).…”

Section: Pre-invasive and Invasive Lesions Of The Cervix During Pregnmentioning

confidence: 99%

Current management of gynecologic cancer in pregnancy

Iavazzo¹,

Minis²,

Gkegkes³

2018

J Turkish German Gynecol Assoc

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Cancer during pregnancy is a particularly challenging complication. The incidence has increased in recent years due to childbearing at advanced maternal ages due to career choices and/or the development of reproductive technology. Approximately two thirds of cancer cases during pregnancy comprise invasive cervical cancers and breast cancer. Cancer during gestation is characterized by a need for specialized treatment due to major changes in the hormonal profile (estrogen-progesterone), metabolism (enhancement of anabolism), hemodynamic changes (hyperdynamic circulation), immunologic changes (cell-mediated and humoral immunity), and increased angiogenesis (increased blood flow towards the uterus). Moreover, the management of such patients is based on the trimester of pregnancy, type and stage of cancer, and informed consent of the mother based on her wishes. The optimal treatment of cancer during pregnancy remains elusive because there are limited data from retrospective studies with small samples. As a result, it is crucial that data regarding survival of the women and long-term follow-up of the children from different cancer centers and registries are shared. This need is dictated by the fact that the incidence of cancer during pregnancy will continue to rise as child-bearing age continues to increase.

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Cancer and Pregnancy

Litton

2019

Holland‐Frei Cancer Medicine

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Overview The diagnosis of cancer during pregnancy is a clinical and emotional challenge for both the patient and the caregivers. A multidisciplinary approach including medical oncologists, surgeons, radiation oncologists, and obstetrics is vital to coordinate the treatment of the mother and the monitoring of the fetus. The available data regarding the treatment of cancer during pregnancy, including staging, surgery, radiation, and systemic therapy as well as outcomes for the patients and the children exposed to chemotherapy in utero is reviewed.

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Management and outcome of cervical cancer diagnosed in pregnancy

Cited by 32 publications

References 21 publications

Management of cervical cancer during pregnancy– literature review

Management of cervical cancer during pregnancy– literature review

Current management of gynecologic cancer in pregnancy

Cancer and Pregnancy

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