A 33-year-old woman with hypertrophic cardiomyopathy (HCM) presents for a septal myectomy. The preoperative transthoracic echocardiogram shows normal left ventricular (LV) function, severe hypertrophy of the interventricular septum, and systolic anterior motion (SAM) of the anterior mitral valve leaflet (AMVL) with moderate mitral regurgitation (MR). The resting peak gradient through the LV outflow tract (LVOT) is elevated at 67 mm·Hg.
DISCUSSIONSAM is defined as the anterior translation of 1 or both mitral valve (MV) leaflets into the LVOT during systole. 1 The extent of this translation is variable and leads to differing degrees of SAM, ranging from no hindrance to blood flow to profound LVOT obstruction (LVOTO) and cardiovascular collapse. This variability results from the dynamic nature of SAM, because its presence and severity depend on the loading conditions and contractile state of the heart. 2 Decreased LV end-diastolic volume and systemic vascular resistance, as well as increased LV contractility and chronotropy can all precipitate or exacerbate SAM. The clinical significance of SAM depends on the degree of LVOTO, which corresponds to the onset, extent, and duration of mitral-septal contact. 2 The treatment of hemodynamically significant SAM focuses on alleviating LVOTO. While SAM is a common cause of LVOTO, there are also other potential etiologies (Table 1).