Management and Complications of Short Bowel Syndrome: an Updated Review

Abstract

Short bowel syndrome (SBS) is defined as loss of bowel mass from surgical resection, congenital defects, or disease. Intestinal failure (IF) includes the subset of SBS unable to meet nutrition needs with enteral supplements and requires parenteral nutrition (PN). The parenteral treatment of SBS is now a half-century old. Recent pharmacologic treatment (GLP-2 analogues) has begun to make a significant impact in the care and ultimate management of these patients such that the possibility of reducing PN requirements in formerly PN-dependent patients is a now a real possibility. Finally, newer understanding and possible treatment for some of the complications related to IF have more recently evolved and will be an emphasis of this report. This review will focus on developments over the last 10 years with the goal of updating the reader to new advances in our understanding of the care and feeding of the SBS patient.

Impact of gastrointestinal disease states on oral drug absorption – implications for formulation design – a PEARRL review

“…Short bowel syndrome (SBS) is a malabsorption disorder as a result of the loss of a large part of the bowel due to surgical resection, congenital defects or disease resulting in a remaining intestinal length of less than 200 cm . The diminished intestinal surface area impedes absorption and, thus, causes the dehydration and malnutrition with micronutrients and macronutrients of patients with SBS which cannot always be overcome with enteral supplements .…”

Fecal microbiota signatures of adult patients with different types of short bowel syndrome

“…Short bowel syndrome (SBS) has been defined as loss of bowel or enterocyte mass from surgical resection, congenital defects, or disease . In adults, most cases occur as a consequence of massive small bowel resection due to postoperative complications, mesenteric vascular disease, Crohn's disease, and trauma .…”

“…Short bowel syndrome (SBS) has been defined as loss of bowel or enterocyte mass from surgical resection, congenital defects, or disease. 1 In adults, most cases occur as a consequence of massive small bowel resection due to postoperative complications, mesenteric vascular disease, Crohn's disease, and trauma. 2 The remaining small intestine lacks sufficient surface area and functional capacity to fully digest and absorb nutrients, resulting in frequent dependency on parenteral nutrition (PN).…”

Growth Hormone Resistance—Special Focus on Inflammatory Bowel Disease

“…Depending on the resected area, the absorption of water, minerals, vitamins, fat, protein, or other nutrients may be compromised [33]. …”