Mammography with Computer-aided Detection: Reproducibility Assessment—Initial Experience

Zheng, Bin; Hardesty, Lara A.; Poller, William R.; Sumkin, Jules H.; Golla, Sara

doi:10.1148/radiol.2281020489

Cited by 46 publications

(27 citation statements)

References 14 publications

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“…30 Zheng and coworkers reported that the sensitivity for the detection of clustered microcalcifications is high at 96% but that sensitivity for mass is only 66.7% to 70.8%. 31 The authors also noted that the abnormalities in their study were visible on both views and that they were not particularly subtle. Further improvements must be achieved in the detection of masses for CAD systems to be sufficiently reliable for general use, and for the possibility of achieving the increased sensitivity of a second reader.…”

Section: How Frequently Are Breast Cancers Missed By Mammography?mentioning

confidence: 77%

Mammographic Diagnosis of Breast Cancer

Mitnick¹

2005

Breast Cancer

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Section: How Frequently Are Breast Cancers Missed By Mammography?mentioning

confidence: 77%

Mammographic Diagnosis of Breast Cancer

Mitnick¹

2005

Breast Cancer

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“…Their results are not akin to ours (100% for malignant calcifications, 85% for high-risk calcifications and 61% for benign calcifications) and this may represent the differences from using direct (our study) vs indirect CAD (with digitisation of images) systems. In the field of CAD, the issue of reliability and reproducibility, which has been shown to be far from perfect in screen-film mammography (SFM) [2,13,14] as a result of mechanical scanning, virtually does not exist in FFDM since the mechanical process of scanning is avoided and CAD software is directly applied to the digital mammogram. Amorphous calcifications are frequently overlooked on SFM and can contribute to a substantial number of missed carcinomas [9,12,15,16].…”

Section: Discussionmentioning

confidence: 99%

“…Computer-aided detection (CAD) systems help radiologists with the perception of the cancer, marking regions of interest on the screen. The use of CAD software primarily in full-field digital mammography (FFDM), also known as direct CAD (d-CAD), does not require digitisation of the films and by definition, once an image is acquired, the CAD detection result will be reproducible when the same d-CAD scheme is applied repeatedly to such an image [2].…”

mentioning

confidence: 99%

Evaluation of breast amorphous calcifications by a computer-aided detection system in full-field digital mammography

Scaranelo¹,

Eiada²,

Bukhanov³

et al. 2012

BJR

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Objectives: The purpose of this study was to evaluate the performance of a direct computer-aided detection (d-CAD) system integrated with full-field digital mammography (FFDM) in assessment of amorphous calcifications. Methods: From 1438 consecutive stereotactic-guided biopsies, FFDM images with amorphous calcifications were selected for retrospective evaluation by d-CAD in 122 females (mean age, 56 years; range, 35-84 years). The sensitivity, specificity, accuracy and false-positive rate of the d-CAD system were calculated in the total group of 124 lesions and in the subgroups based on breast density, mammographic lesion distribution and extension. Logistic regression analysis was used to stratify the risk of malignancy by patient risk factors and age. Results: The d-CAD marked all (36/36) breast cancers, 85% (11/13) of the high-risk lesions and 80% (60/75) of benign amorphous calcifications (p,0.01) correctly. The sensitivity, specificity and diagnostic accuracy for the combined malignant and ''highrisk'' lesions was 96, 80 and 86%, respectively. The likelihood of malignancy was 29%. There was no significant difference between the marking of fatty or dense breasts (p.0.05); however, d-CAD marks showed differences for small (,7 mm) lesions (p50.02) and clustered calcifications (p50.03). The false-positive rate of d-CAD was 1.76 marks per full examination. Conclusion: The d-CAD system correctly marked all biopsy-proven breast cancers and a large number of biopsy-proven high-risk lesions that presented as amorphous calcifications. Given our 29% likelihood of malignancy, imaging-guided biopsy appears to be a reasonable recommendation in cases of amorphous calcifications marked by d-CAD.

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“…Contradicting these unpublished data of the companies, it is now well accepted that the reproducibility of CAD systems with a secondary digitization of conventional images is limited by its nature. The first study describing this lack of technology was published by Malich et al in 2000; other studies have supported these findings [74][75][76].…”

Section: Reliabilitymentioning

confidence: 90%

CAD for mammography: the technique, results, current role and further developments

2006

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CAD systems, developed to assist the radiologist in the detection of suspicious lesions on mammograms, are currently controversially discussed. The highly sensitive detection of malignant structures including priors by CAD is linked with a low specific performance and a high rate of falsely positive markings. This causes controversial results regarding the effect of CAD systems for the diagnosing radiologist. This review aims to give an overview of the current literature, to state the currently discussed controversial results of CAD and to give an outlook on the next developments, which are not limited to senology, but include many other applications of CAD systems in radiology.

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Mammography with Computer-aided Detection: Reproducibility Assessment—Initial Experience

Cited by 46 publications

References 14 publications

Mammographic Diagnosis of Breast Cancer

Mammographic Diagnosis of Breast Cancer

Evaluation of breast amorphous calcifications by a computer-aided detection system in full-field digital mammography

CAD for mammography: the technique, results, current role and further developments

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