Mammographic density and its interaction with other breast cancer risk factors in an Asian population

Wong, Chow Cher; Lim, Grace; Gao, Fei; Jakes, Rupert; Offman, Judith; Chia, Kee Seng; Duffy, Stephen W.

doi:10.1038/sj.bjc.6606085

Cited by 63 publications

(68 citation statements)

References 19 publications

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“…Secondly, it may be possible to reduce or even eliminate confounding with BMI by choosing an absolute (rather than relative) density measure. 37,38 Classic anthropo metric measures of adiposity (BMI and waist circumference) have been shown to be as good for adjusting density as adiposity measures from whole body estimated by dual x-ray absorptiometry and CT. 39 It is not yet clear whether relative or absolute breast density is a better predictor of risk. 22,25,38 Vachon et al 40 found that absolute dense area had a similar risk predictive potential as percent density.…”

Section: Breast Density and Breast Cancer Riskmentioning

confidence: 99%

Clinical and epidemiological issues in mammographic density

et al. 2011

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High mammographic density is associated with an increased risk of breast cancer, and of all known breast cancer risk factors has the greatest attributable fraction. Mammographic density is estimated to account for 16% of all breast cancers, but can be altered by endogenous and exogenous hormonal factors, and generally declines with age. Confounding factors such as age, parity, menopausal status and BMI make the interpretation of mammographic density particularly challenging. Furthermore, none of the established means of measuring mammographic density are entirely satisfactory because they are time consuming or subjective. It is hoped that by adding information regarding mammographic density to existing models of breast cancer risk assessment, the accuracy of individual risk assessments can be improved. Although mammographic density has clearly been shown to be a powerful factor for predicting the risk of developing breast cancer, its potential role in assessing hormonal preventive regimens and helping to tailor screening algorithms cannot be fully realized until we have more-precise, simple and reproducible density measures.

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Section: Breast Density and Breast Cancer Riskmentioning

confidence: 99%

Clinical and epidemiological issues in mammographic density

et al. 2011

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“…Known breast cancer risk factors such as late age at first birth, nulliparity, and postmenopausal hormone therapy are positively associated with mammographic density [7,8]. Increasing age, low parity, and body mass index (BMI), however, are negatively associated with mammographic density [9,10].…”

Section: Introductionmentioning

confidence: 99%

Alcohol intake and mammographic density in postmenopausal Norwegian women

Qureshi

Couto

Hofvind

et al. 2011

Breast Cancer Res Treat

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Mammographic density is a strong risk factor for breast cancer. While alcohol intake has been associated with increased breast cancer risk, the association between alcohol consumption and mammographic density is not clear. We assessed the association between alcohol consumption and mammographic density among women who participated in the Norwegian Breast Cancer Screening Program in 2004. Mammographic density was assessed on digitized mammograms from 2,251 postmenopausal women aged 50-69 years, using a computer assisted method. Current intake of beer, wine (red and white), and liquor was assessed using a validated food frequency questionnaire. Non-drinkers were defined as complete abstainers (i.e., those who reported no intake of any type of alcohol). We used multivariate linear regression models to estimate least square means of percent mammographic density by categories of alcohol intake with adjustment for potential confounders. We also checked for possible effect modification by stratifying the analyses by age, body mass index, and hormone therapy. The mean percent mammographic density was almost similar for drinkers 18.3% (95% CI: 17.6-18.9%) and non-drinkers 17.8% (95% CI: 16.1-19.4%) (P = 0.59). There was no indication that amount of alcohol consumed was associated with percent mammographic density, with a mean percent density among women with the highest intake (>90 g of alcohol per week) of 18.2% (95% CI: 16.9-19.0%), only slightly different from that of non-drinkers 18.3% (17.3-19.6%) (P for trend = 0.99). There was no association between any type of alcohol consumed and mammographic density.There was no effect modification by body mass index, age, or hormone therapy use. We found no evidence of an association between alcohol intake and percent mammographic density.

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“…Previous studies from Western countries have shown that women with extremely dense breasts (75 % or more dense tissue in breasts) have four to six times greater risk of developing breast cancer than women with fatty breasts (25 % or less dense tissue in breasts) [22][23][24][25][26][27][28][29][30]. Reports from Asian countries, mainly from Japan, have also identified dense breast tissue as a risk factor for breast cancer [31][32][33].…”

Section: Breast Density As a Risk Factor For Breast Cancermentioning

confidence: 93%

Breast density: the trend in breast cancer screening

Machida¹,

Tozaki

Shimauchi

et al. 2015

Breast Cancer

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The primary modality for breast cancer screening is mammography. Recent investigations, however, have indicated that an insufficient number of life-threatening cases have been detected by mammography while mammography can often results in a large number of overdiagnoses. To make breast cancer screening more effective, potential factors that influence screening efficacy need to be elucidated. Breast density is one of limiting factors for breast cancer detection using mammography. In this article, influence of breast density on breast screening is explained. Current topics related to breast density, objective assessment of breast density using applications, revision of breast composition classification in Breast Imaging-Reporting and Data System Mammography fifth edition, and legislative movement regarding breast density in the United States, are also mentioned in this review article.

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Mammographic density and its interaction with other breast cancer risk factors in an Asian population

Cited by 63 publications

References 19 publications

Clinical and epidemiological issues in mammographic density

Clinical and epidemiological issues in mammographic density

Alcohol intake and mammographic density in postmenopausal Norwegian women

Breast density: the trend in breast cancer screening

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