Mammographic Breast Density Profile of Jordanian Women With Normal and Breast Cancer Findings

Al-Mousa, Dana S; Alakhras, Maram; Spuur, Kelly; Alewaidat, Haytham; Rawashdeh, Mohammad; Abdelrahman, Mostafa; Brennan, Patrick C.

doi:10.1177/1178223420921381

Cited by 5 publications

(5 citation statements)

References 33 publications

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“…20 In the largest study to date, involving 73,974 Korean women, metabolic syndrome and its components were associated with dense breasts (MD-D) in premenopausal women, while in both premenopausal and postmenopausal women high blood glucose and insulin resistance were positively associated with dense breasts. 22 Our findings on MD have validity; the distribution of MD categories [25][26][27] in this study and the inverse relation between MD and age and BMI 25 27-29 are consistent with the available literature. Further, the registered prevalence of the studied risk factors is in keeping with reports from Saudi Arabia and the world.…”

Section: Original Researchsupporting

confidence: 89%

Association of Mammographic Density and Benign Breast Calcifications Individually or Combined with Hypertension, Diabetes, and Hypercholesterolemia in Women ≥40 Years of Age: A Retrospective Study

Al-Mohaissen

Alkhedeiri

Almadani

et al. 2022

Journal of Investigative Medicine

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Recent evidence has linked certain mammographic characteristics, including breast calcifications (Bcs) and mammographic density (MD), with atherosclerotic cardiovascular disease risk factors in women, but data are limited and inconsistent. We aimed to evaluate the association of MD and/or Bcs with hypertension, diabetes, and hypercholesterolemia in women ≥40 years of age. Through hospital electronic records, we retrospectively identified mammograms of non-pregnant women aged ≥40 years and without breast cancer and retrieved reports and relevant data. MD and Bcs were recorded; risk factor status was diagnosed based on treatment profile and clinical and laboratory data. In total, 1406 women were included. MD was inversely related to hypertension, diabetes, hypercholesterolemia, triglyceride levels, age, and body mass index (BMI) (p value for trend <0.001). Bcs were positively associated with hypertension, diabetes, hypercholesterolemia, age, BMI, and elevated creatinine (p<0.05). Controlling for age and BMI, MD category A (MD-A) was independently associated with hypercholesterolemia; Bcs were independently associated with diabetes. Combining MD-A with Bcs did not increase the odds significantly. Analysis for additive interactions revealed a significant interaction between MD-A and BMI, increasing the odds of hypertension, and a trend for increased odds of diabetes by adding MD-A and/or Bcs to BMI. Decreased MD and presence of Bcs are associated with hypertension, diabetes, and hypercholesterolemia in women ≥40 years of age. MD-A may represent a new obesity index independently associated with hypercholesterolemia and additive to hypertension risk. Bcs are independently associated with diabetes. Combining MD and Bcs did not improve the odds significantly, which may reflect mechanistic differences.

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Section: Original Researchsupporting

confidence: 89%

Association of Mammographic Density and Benign Breast Calcifications Individually or Combined with Hypertension, Diabetes, and Hypercholesterolemia in Women ≥40 Years of Age: A Retrospective Study

Al-Mohaissen

Alkhedeiri

Almadani

et al. 2022

Journal of Investigative Medicine

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“…Figure 2 shows that high density MBD (heterogeneously and dense categories) accounted for 62.4 % of all participants. This is higher than the reported percentage among women in the USA (23) and lower than the reported percentage among women in Jordon (24).…”

Section: Resultscontrasting

confidence: 73%

Factors Associated with Mammographic Breast Density among Premenopausal and Menopausal Women in Karachi Pakistan

Shamsi

Afzal

Shamsi

et al. 2021

Preprint

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Background: There are no studies done to evaluate the distribution of mammographic breast density and factors associated with it among Pakistani women. Methods: Participants included 477 women, who had received either diagnostic or screening mammography at two hospitals in Karachi Pakistan. Mammographic breast density was assessed using the Breast Imaging Reporting and Data System. In person interviews were conducted using a detailed questionnaire, to assess risk factors of interest, and venous blood was collected to measure serum vitamin D level at the end of the interview. To determine the association of potential factors with mammographic breast density, multivariable polytomous logistic regression was used. Results: High-density mammographic breast density (heterogeneously and dense categories) was found in 62.4 % of women. There was a significant association of both heterogeneously dense and dense breasts with women of a younger age group < 45 years (OR= 2.68, 95% CI= 1.60-4.49) and (OR= 4.83, 95% CI= 2.54-9.16) respectively. Women with heterogeneously dense and dense breasts vs. fatty and fibroglandular breasts had a higher history of benign breast disease (OR = 1.90, 95% CI= 1.14–3.17) and (OR= 3.61, 95%CI= 1.90-6.86) respectively. There was an inverse relationship between breast density and body mass index. Women with dense breasts and heterogeneously dense breasts had lower body mass index (OR= 0.94 95% CI= 0.90-0.99) & (OR= 0.81, 95%CI= 0.76-0.87) respectively. There was no association of mammographic breast density with serum vitamin D levels, diet, and breast cancer. Conclusion: The findings of a positive association of higher mammographic density with younger age and benign breast disease and a negative association between body mass index and breast density are important findings that need to be considered in developing screening guidelines for the Pakistani population.

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“…The high percentage of high MBD (62.4%) in Pakistani women is important information and will be helpful in planning or advising for an organized screening mammography program in Pakistan in future. This is higher than the reported percentage among women in the USA [ 47 ] and lower than the reported percentage among women in Jordon [ 48 ]. High density breast, on one hand, increases the rates of false-negative diagnosis and on the other hand, there is a requirement of additional tests.…”

Section: Discussioncontrasting

confidence: 76%

Factors associated with mammographic breast density among women in Karachi Pakistan

et al. 2021

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Background There are no studies done to evaluate the distribution of mammographic breast density and factors associated with it among Pakistani women. Methods Participants included 477 women, who had received either diagnostic or screening mammography at two hospitals in Karachi Pakistan. Mammographic breast density was assessed using the Breast Imaging Reporting and Data System. In person interviews were conducted using a detailed questionnaire, to assess risk factors of interest, and venous blood was collected to measure serum vitamin D level at the end of the interview. To determine the association of potential factors with mammographic breast density, multivariable polytomous logistic regression was used. Results High-density mammographic breast density (heterogeneously and dense categories) was high and found in 62.4% of women. There was a significant association of both heterogeneously dense and dense breasts with women of a younger age group < 45 years (OR 2.68, 95% CI 1.60–4.49) and (OR 4.83, 95% CI 2.54–9.16) respectively. Women with heterogeneously dense and dense breasts versus fatty and fibroglandular breasts had a higher history of benign breast disease (OR 1.90, 95% CI 1.14–3.17) and (OR 3.61, 95% CI 1.90–6.86) respectively. There was an inverse relationship between breast density and body mass index. Women with dense breasts and heterogeneously dense breasts had lower body mass index (OR 0.94 95% CI 0.90–0.99) and (OR 0.81, 95% CI 0.76–0.87) respectively. There was no association of mammographic breast density with serum vitamin D levels, diet, and breast cancer. Conclusions The findings of a positive association of higher mammographic density with younger age and benign breast disease and a negative association between body mass index and breast density are important findings that need to be considered in developing screening guidelines for the Pakistani population.

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Mammographic Breast Density Profile of Jordanian Women With Normal and Breast Cancer Findings

Cited by 5 publications

References 33 publications

Association of Mammographic Density and Benign Breast Calcifications Individually or Combined with Hypertension, Diabetes, and Hypercholesterolemia in Women ≥40 Years of Age: A Retrospective Study

Association of Mammographic Density and Benign Breast Calcifications Individually or Combined with Hypertension, Diabetes, and Hypercholesterolemia in Women ≥40 Years of Age: A Retrospective Study

Factors Associated with Mammographic Breast Density among Premenopausal and Menopausal Women in Karachi Pakistan

Factors associated with mammographic breast density among women in Karachi Pakistan

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