Mammary Hypertrophy Is Not Associated with Increased Estrogen Receptors

Jabs, Arthur D.; Frantz, Andrew G.; Smith-Vaniz, Alison; Hugo, Norman E.

doi:10.1097/00006534-199007000-00010

Cited by 24 publications

(45 citation statements)

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“…Local hypersensitivity of oestrogen receptors for oestrogen has been postulated, 5 but it is not a universal finding. 7 Breast hypertrophy is uncommon at <12 years of age, given that it tends to occur around the time of normal female menarche (average in our community 12.8 years).…”

Section: Discussionmentioning

confidence: 85%

Virginal breast hypertrophy of an 11‐year‐old girl

Koves

Zacharin

2007

J Paediatrics Child Health

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Section: Discussionmentioning

confidence: 85%

Virginal breast hypertrophy of an 11‐year‐old girl

Koves

Zacharin

2007

J Paediatrics Child Health

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“…The findings that human mammary stromal cells from breast tissue of young teenage girls and pregnant women are similar and contain the greatest number of estrogen receptor alpha protein and progesterone receptor protein support this hypothesis [15]. Morimoto et al [9] suggested that the etiology of JHB is related to local hypersensitivity of estrogen receptors for estrogen [16], compared with usual mammary hypertrophy in which the status of estrogen receptors was found to be irrelevant to the hypertrophy.…”

Section: Discussionmentioning

confidence: 94%

“…In all our patients, despite long pedicle, areola-nipple complex survived. In spite of the common practice of reduction surgery, almost all surgeons who cared for more than one patient with JHB concluded that nearly all breast reduction procedures fail and needed to be repeated [2][3][4][5][6][7][8][9][10]. In only two presentations (including our patient number two), the arrest of breast enlargement was achieved after one reduction surgery [4].…”

Section: Discussionmentioning

confidence: 99%

“…Gigantomastia is treated surgically by breast reduction or simple, total, or subcutaneous mastectomy. Almost all patients described in the literature after surgery developed recurrent breast enlargement and underwent repeated breast reduction or subcutaneous mastectomy [2][3][4][5][6][7][8][9][10]. Baker et al [4] suggested that older patients may be treated definitively with reduction surgery alone, and young patients should be treated by subcutaneous mastectomy because of high rate of recurrence.…”

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confidence: 99%

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Familial juvenile hypertrophy of the breast

Govrin-Yehudain

Kogan

Cohen

et al. 2004

Journal of Adolescent Health

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“…JHB is a rare condition leading to gigantomastia unilateral or bilaterally in peripubertal females. 2,[6][7][8] The first case of JHB was reported by Durston in 1669. 3,6,9 and only 75 cases reported ever since.…”

mentioning

confidence: 99%

Modification of wise pattern based design with free nipple areolar complex graft in a case of juvenile hypertrophy of the breasts

Prasetyono¹,

Guizot²

2008

Med J Indones

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Reduction mammoplasty with wise pattern based design modification 13 Modification of wise pattern based design with free nipple areolar complex graft in a case of juvenile hypertrophy of the breasts Theddeus OH Prasetyono, Vivi V Guizot Abstrak Juvenile hypertrophy of the breast (JHB) merupakan gigantomastia unilateral atau bilateral pada wanita peripubertal dan merupakan kasus jarang. Kelainan ini terbatas pada payudara berupa pertumbuhan dan perkembangan yang tidak normal. Pembesaran payudara bilateral atau unilateral tidak hanya mengakibatkan gangguan fisik tetapi juga psikis. Etiologinya sulit ditentukan, tetapi kelainan ini menggambarkan adanya hipersensitifitas organ akibat gangguan regulasi endokrin. Terapi terbaik berupa pembedahan yaitu mastektomi atau mammaplasti reduksi. Laporan ini menyajikan kasus seorang wanita berusia 30 tahun dengan JHB. Pertumbuhan payudara kirinya dimulai saat pubertas dan terus membesar selama setahun. Operasi dilaksanakan berupa reduksi mammaplasti dengan wise pattern based design. Setelah dua tahun pasien tidak memiliki tanda-tanda rekurensi dan kedua payudaranya tampak simetris dengan parut yang memuaskan. (Med J Indones 2008; AbstractJuvenile hypertrophy of the breast (JHB) is a rare condition leading to gigantomastia unilaterally or bilaterally in peripubertal females. The pathology is limited usually to the breast, with otherwise normal growth and development and without any other deformities. The rapid bilateral or unilateral growth of the breast in adolescent girls leads to severe physical and psychological problems. The etiology remains elusive, but it is believed to represent an end-organ hypersensitivity during a period of intense endocrine regulatory stress. The best treatment is surgical whereas the younger patients better treated with mastectomy to anticipate the high recurrency rate, while older women is best treated with reduction mammaplasty. We report one case of a woman who had a unilateral JHB. The growth of the left breast started in her pubertal age and kept growing for one year. She was treated surgically with Wise pattern based design. After two years, she had no recurrent enlargement and aesthetically, the symmetry of both breasts is achieved with a satisfying scar. (Med J Indones 2008; 17: 13-9) Keywords: juvenile hypertrophy of the breast, reduction mammaplasty, wise pattern based design

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Mammary Hypertrophy Is Not Associated with Increased Estrogen Receptors

Cited by 24 publications

References 0 publications

Virginal breast hypertrophy of an 11‐year‐old girl

Virginal breast hypertrophy of an 11‐year‐old girl

Familial juvenile hypertrophy of the breast

Modification of wise pattern based design with free nipple areolar complex graft in a case of juvenile hypertrophy of the breasts

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