Mammary carcinoma model: correlation of macromolecular contrast-enhanced MR imaging characterizations of tumor microvasculature and histologic capillary density.

Dijke, Cornelis F. van; Brasch, Robert C.; Roberts, Timothy P. L.; Weidner, Norbert; Mathur, Ashwini; Shames, David M.; Mann, Jeffry S.; Demšar, Franci; Lang, Philipp; Schwickert, Heidi C.

doi:10.1148/radiology.198.3.8628876

Cited by 199 publications

(104 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our findings suggest that ICG, although not developed as a cancer targeting dye, could find applications in DOT mammography. Additionally, it should be pointed out that the study of macromolecular contrast agent kinetics enables the independent estimation of vascularization and permeability (47)(48)(49). Such differentiation has been demonstrated by MRI using albuminbound-Gd and is examined by the MR community as a surrogate to increasing specificity (47,50,51).…”

Section: Discussionmentioning

confidence: 99%

Concurrent MRI and diffuse optical tomography of breast after indocyanine green enhancement

Ntziachristos

Yodh

Schnall

et al. 2000

Proc. Natl. Acad. Sci. U.S.A.

748

525

View full text Add to dashboard Cite

We present quantitative optical images of human breast in vivo. The images were obtained by using near-infrared diffuse optical tomography (DOT) after the administration of indocyanine green (ICG) for contrast enhancement. The optical examination was performed concurrently with a magnetic resonance imaging (MRI) exam on patients scheduled for excisional biopsy or surgery so that accurate image coregistration and histopathological information of the suspicious lesions was available. The ICG-enhanced optical images coregistered accurately with Gadolinium-enhanced magnetic resonance images validating the ability of DOT to image breast tissue. In contrast to simple transillumination, we found that DOT provides for localization and quantification of exogenous tissue chromophore concentrations. Additionally our use of ICG, an albumin bound absorbing dye in plasma, demonstrates the potential to differentiate disease based on the quantified enhancement of suspicious lesions.optical properties ͉ contrast agents ͉ MRI coregistration

show abstract

Section: Discussionmentioning

confidence: 99%

Concurrent MRI and diffuse optical tomography of breast after indocyanine green enhancement

Ntziachristos

Yodh

Schnall

et al. 2000

Proc. Natl. Acad. Sci. U.S.A.

748

525

View full text Add to dashboard Cite

show abstract

“…Importantly, vascular density can be measured in vivo with imaging techniques that map regional blood volume. Numerous studies have established a tight relationship between angiogenesis and regional blood volume (13)(14)(15)(16)(17), including in the brain where regional angiogenesis is coupled to regional cerebral blood volume (CBV) (18)(19)(20)(21)(22)(23)(24)(25)(26).…”

mentioning

confidence: 99%

An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus

Pereira¹,

Huddleston²,

Brickman³

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

1,157

941

View full text Add to dashboard Cite

With continued debate over the functional significance of adult neurogenesis, identifying an in vivo correlate of neurogenesis has become an important goal. Here we rely on the coupling between neurogenesis and angiogenesis and test whether MRI measurements of cerebral blood volume (CBV) provide an imaging correlate of neurogenesis. First, we used an MRI approach to generate CBV maps over time in the hippocampal formation of exercising mice. Among all hippocampal subregions, exercise was found to have a primary effect on dentate gyrus CBV, the only subregion that supports adult neurogenesis. Moreover, exercise-induced increases in dentate gyrus CBV were found to correlate with postmortem measurements of neurogenesis. Second, using similar MRI technologies, we generated CBV maps over time in the hippocampal formation of exercising humans. As in mice, exercise was found to have a primary effect on dentate gyrus CBV, and the CBV changes were found to selectively correlate with cardiopulmonary and cognitive function. Taken together, these findings show that dentate gyrus CBV provides an imaging correlate of exercise-induced neurogenesis and that exercise differentially targets the dentate gyrus, a hippocampal subregion important for memory and implicated in cognitive aging.hippocampus ͉ in vivo imaging ͉ cerebral blood volume ͉ angiogenesis T he hippocampal formation, a brain circuit made up of separate but interconnected subregions (1), is vital for memory function (2) and is targeted by the aging process (3). The dentate gyrus is the only hippocampal subregion that supports neurogenesis in the adult brain (4-6). Nevertheless, because neurogenesis can only be assessed in postmortem tissue, its functional significance remains undetermined. With this limitation in mind, we have explored different imaging approaches applicable to rodents and humans that might provide an in vivo correlate of neurogenesis.Although imaging radioligands designed to bind newly dividing cells is an attractive approach, positron emission tomography imaging suffers inherently poor resolution and cannot visualize the dentate gyrus. Additionally, radiolabeling newborn cells introduces potential safety concerns. For these reasons, we have focused on MRI technologies instead. Notably, a coupling has been established between neurogenesis and angiogenesis (7,8). The process of angiogenesis, in turn, gradually gives rise to the formation of new blood vessels, increasing regional microvascular density (9-12). Importantly, vascular density can be measured in vivo with imaging techniques that map regional blood volume. Numerous studies have established a tight relationship between angiogenesis and regional blood volume (13-17), including in the brain where regional angiogenesis is coupled to regional cerebral blood volume (CBV) (18)(19)(20)(21)(22)(23)(24)(25)(26).Because CBV can be measured with MRI, we hypothesized that a regionally selective increase in hippocampal CBV might provide an imaging correlate of neurogenesis. This hypothesis was tested in...

show abstract

“…1,2 Increased vascular permeability has also been associated with malignant tumor microvessels and has been evolving as a surrogate marker of tumor angiogenesis and thus tumor grade. 3 Higher permeability has been associated with higher tumor grade [4][5][6][7][8] and has also been shown to decrease in response to antiangiogenic therapy due to decreased tumor growth predicting tumor response. 9 Noninvasive measurement of vascular permeability has been done by using various MR perfusion techniques, which also have been correlated with glioma grading and treatment response.…”

mentioning

confidence: 99%

Quantitative Estimation of Permeability Surface-Area Product in Astroglial Brain Tumors Using Perfusion CT and Correlation with Histopathologic Grade

Jain¹,

Ellika²,

Scarpace³

et al. 2008

AJNR Am J Neuroradiol

132

113

View full text Add to dashboard Cite

BACKGROUND AND PURPOSE: Glioma angiogenesis and its different hemodynamic features, which can be evaluated by using perfusion CT (PCT) imaging of the brain, have been correlated with the grade and the aggressiveness of gliomas. Our hypothesis was that quantitative estimation of permeability surface area product (PS), cerebral blood volume (CBV), cerebral blood flow (CBF), and mean transit time (MTT) in astroglial brain tumors by using PCT will correlate with glioma grade. High-grade gliomas will show higher PS and CBV as compared with low-grade gliomas.

show abstract

Mammary carcinoma model: correlation of macromolecular contrast-enhanced MR imaging characterizations of tumor microvasculature and histologic capillary density.

Abstract: Contrast medium-enhanced MR imaging may prove useful in estimating angiogenic activity in carcinomas. MR imaging may be superior to histologic assay because it is noninvasive, can be used to "sample" the entire tumor, and reflects both anatomic and physiologic characteristics.

Cited by 199 publications

References 0 publications

Concurrent MRI and diffuse optical tomography of breast after indocyanine green enhancement

Concurrent MRI and diffuse optical tomography of breast after indocyanine green enhancement

An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus

Quantitative Estimation of Permeability Surface-Area Product in Astroglial Brain Tumors Using Perfusion CT and Correlation with Histopathologic Grade

Contact Info

Product

Resources

About