Mammary cancer in transgenic mice expressing insulin-like growth factor II (IGF-II)

Bates, Philip D.; Fisher, Rebecca; Ward, Andrew; Richardson, Lindsey; Hill, David J.; Graham, Chris

doi:10.1038/bjc.1995.484

Cited by 180 publications

(100 citation statements)

References 35 publications

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“…Transgenic mice overexpressing growth hormone have a higher frequency of breast cancer (Bates et al, 1995;Hadsell et al, 1996) and disruption of the IGF-1 gene seems to prevent breast tumor formation by viral oncogens (Sell et al, 1993). Human mechanistic studies of the effect of estrogen antagonist drugs on breast carcinogenesis have shown a direct link with IGF-1.…”

Section: Glycemic Index In Chronic Disease Ls Augustin Et Almentioning

confidence: 99%

Glycemic index in chronic disease: a review

et al. 2002

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Aim: The intent of this review is to critically analyze the scientific evidence on the role of the glycemic index in chronic Western disease and to discuss the utility of the glycemic index in the prevention and management of these disease states. Background: The glycemic index ranks foods based on their postprandial blood glucose response. Hyperinsulinemia and insulin resistance, as well as their determinants (eg high energy intake, obesity, lack of physical activity) have been implicated in the etiology of diabetes, coronary heart disease and cancer. Recently, among dietary factors, carbohydrates have attracted much attention as a significant culprit, however, different types of carbohydrate produce varying glycemic and insulinemic responses. Low glycemic index foods, characterized by slowly absorbed carbohydrates, have been shown in some studies to produce beneficial effects on glucose control, hyperinsulinemia, insulin resistance, blood lipids and satiety. Method: Studies on the short and long-term metabolic effects of diets with different glycemic indices will be presented and discussed. The review will focus primarily on clinical and epidemiological data, and will briefly discuss in vitro and animal studies related to possible mechanisms by which the glycemic index may influence chronic disease.

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Section: Glycemic Index In Chronic Disease Ls Augustin Et Almentioning

confidence: 99%

Glycemic index in chronic disease: a review

et al. 2002

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“…Overexpression of IGF-I (Hadsell et al, 2000) or IGF-II (Bates et al, 1995;Pravtcheva and Wise, 1998) in the mammary epithelium results in tumor development, albeit with long latency. Recently, mammary specific overexpression of a constitutively active IGF-IR (Carboni et al, 2005) or wildtype IGF-IR (Jones et al, 2007) has been shown to induce rapid tumor formation by 2 months of age.…”

Section: Introductionmentioning

confidence: 99%

Reversibility and recurrence of IGF-IR-induced mammary tumors

et al. 2009

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“…Elevated levels of serum IGF-I and reduced levels of serum IGFBP-3 have been associated with an increased relative risk for breast cancer especially in premenopausal women under the age of 50 years (Hankinson et al, 1998). Finally, a direct association between IGF-I and IGF-II overexpression and mammary tumorigenesis has been established in transgenic mice (Bates et al, 1995;Pravtcheva and Wise, 1998;Hadsell et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Transgenic overexpression of IGF-IR disrupts mammary ductal morphogenesis and induces tumor formation

et al. 2006

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Overexpression and hyperactivation of the type I insulinlike growth factor receptor (IGF-IR) has been observed in human breast tumor biopsies. In addition, in vitro studies indicate that overexpression of IGF-IR is sufficient to transform cells such as mouse embryo fibroblasts and this receptor promotes proliferation and survival in breast cancer cell lines. To fully understand the function of the IGF-IR in tumor initiation and progression, transgenic mice containing human IGF-IR under a doxycyclineinducible MMTV promoter system were generated. Administration of 2 mg/ml doxycycline in the animals' water supply beginning at 21 days of age resulted in elevated levels of IGF-IR in mammary epithelial cells as detected by Western blotting and immunohistochemistry. Whole mount analysis of 55-day-old mouse mammary glands revealed that IGF-IR overexpression significantly impaired ductal elongation. Moreover, histological analyses revealed multiple hyperplasic lesions in the mammary glands of these 55-day-old mice. The formation of palpable mammary tumors was evident at approximately 2 months of age and was associated with increased levels of IGF-IR signaling molecules including phosphorylated Akt, Erk1/Erk2 and STAT3. Therefore, these transgenic mice provide evidence that IGF-IR overexpression is sufficient to induce mammary epithelial hyperplasia and tumor formation in vivo and provide a model to further understand the function of IGF-IR in mammary epithelial transformation.

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Mammary cancer in transgenic mice expressing insulin-like growth factor II (IGF-II)

Abstract: S_rThe effect of insulhn-like growth factor II (IGF-II) on

Cited by 180 publications

References 35 publications

Glycemic index in chronic disease: a review

Glycemic index in chronic disease: a review

Reversibility and recurrence of IGF-IR-induced mammary tumors

Transgenic overexpression of IGF-IR disrupts mammary ductal morphogenesis and induces tumor formation

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