Mammary and extramammary Paget's disease: an immunohistochemical study of 83 cases

Liegl, Bernadette; Leibl, Sebastian; Gogg-Kamerer, Margit; Tessaro, Brigitte; Lc, Horn; Moinfar, Farid

doi:10.1111/j.1365-2559.2007.02633.x

Cited by 109 publications

(63 citation statements)

References 30 publications

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“…The differential diagnosis was primary or secondary extramammary Paget's disease, squamous cell carcinoma and metastatic adenocarcinoma. The tumor cells were positive for CK5/6 and CK7, so the immunohistochemical features excluded primary extramammary Paget's disease [4]. Screening colonoscopy and cystoscopy revealed no malignancy in the lower gastrointestinal and urinary tract, which excluded secondary extramammary Paget's disease.…”

Section: Case Reportmentioning

confidence: 99%

Syringocystadenocarcinoma Papilliferum in the Perianal Area

et al. 2015

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Syringocystadenocarcinoma papilliferum (SCACP) is a very rare cutaneous adnexal neoplasm. SCACP presents histologic variability, and it is difficult to establish the diagnosis from a punch biopsy. SCACP has an overall configuration similar to that of syringocystadenoma papilliferum (SCAP). When we diagnose SCACP, the histologic features of SCAP can be contributing and immunohistochemical staining is useful. Our case shows the histologic variability of SCACP and the pitfalls of a punch biopsy for the diagnosis of SCACP.

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Section: Case Reportmentioning

confidence: 99%

Syringocystadenocarcinoma Papilliferum in the Perianal Area

et al. 2015

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“…They also occur as a normal constituent of genital skin in association with mammary like glands of the vulva [5]. The idea that Toker cells are precursors of mammary and extramammary Paget's disease is disputed by differences in immunoprofile and morphological appearance compared to Paget cells [6, 7]. The concept that Paget cells are in fact malignant keratinocytes, which has been transformed in situ, has been put forward as the transformation theory [8].…”

Section: Introductionmentioning

confidence: 99%

Angiogenesis in Paget's Disease of the Vulva and the Breast: Correlation with Microvessel Density

Ellis

MacLean

Fong

et al. 2012

Journal of Oncology

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Our understanding of the pathogenesis of Paget's disease of the vulva and the breast remains limited. Current evidence supports the fact that angiogenesis plays an important role in the pathogenesis of several diseases. Therefore, we sought to define its role, as correlated with microvessel density, in Paget's disease of the vulva and the breast. Microvessels were analysed using anti-von Willebrand factor antibody in 105 cases of Paget's disease of the vulva and the breast comprising 71 cases of Paget's disease of the vulva, including 8 cases with invasive disease, and 34 cases of Paget's disease of the breast. The latter included 12 cases with DCIS, 5 cases with both DCIS and invasive carcinoma, and 6 with carcinoma alone. Eleven cases had no underlying tumour identified. Increased microvessel density was demonstrated in Paget's disease of the breast with DCIS and with carcinoma alone compared to Paget's disease of the breast alone, P < 0.08 and P < 0.013, respectively. There were no significant differences in microvessel density in the vulval cases. Neovascularisation is an important process in the development of Paget's disease of the breast. Other biological and molecular processes are more involved in the pathogenesis of Paget's disease of the vulva.

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“…The origin of these cells is unclear; most authors assume a relationship to apocrine glands because they occur in apocrine gland-bearing skin 1 and most but not all Paget cells stain positively for GCDFP-15, a marker of apocrine cells. 2 About 25% of all cases have an underlying cutaneous adnexal carcinoma, mostly of apocrine type. A further 10% of patients have an internal carcinoma.…”

Section: Introductionmentioning

confidence: 99%

Clinicopathologic characteristics of extramammary Paget’s disease of the scrotum associated with sweat gland adenocarcinoma—a clinical retrospective study

Dong

Dai

Jin

et al. 2011

Journal of the Chinese Medical Association

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Extramammary Paget's disease of the scrotum with sweat gland adenocarcinoma is a rare malignant tumor. This study aims to summarize the clinicopathologic characteristics related to the prognosis of scrotal Paget's disease with underlying sweat gland adenocarcinoma. Clinical datum of four patients with scrotal Paget's disease with sweat gland carcinoma, treated in Beijing Chao-Yang Hospital from 2002 to 2009 was analyzed, and a literature review was conducted. The typical manifestation of scrotal Paget's disease with sweat gland carcinoma was eczematoid-like skin lesions. All patients underwent primary lesion resection plus inguinal lymphadenectomy. Three patients had inguinal lymph metastasis. One of them developed distant metastases in bone and bone marrow and died of metastatic carcinoma. The dead patient had higher serum carcinoma embryonic antigen (CEA) level, Her-2 overexpression and shorter disease course than the other patients. The other patients were observed for at least 3 years, and lived without tumor. Scrotal Paget's disease with sweat gland adenocarcinoma may be prone to inguinal lymph node and bone metastasis. Serum CEA level, Her-2 overexpression, dermis and lymphovascular invasion may be associated with the prognosis of scrotal Paget's disease with sweat gland adenocarcinoma. The primary lesion resection plus inguinal lymphadenectomy is the major treatment for scrotal Paget's disease with sweat gland adenocarcinoma. The effect of combination chemotherapy in the treatment of metastatic extramammary Paget's disease remains to be proven by prolonged follow-up and wide experience.

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Mammary and extramammary Paget's disease: an immunohistochemical study of 83 cases

Cited by 109 publications

References 30 publications

Syringocystadenocarcinoma Papilliferum in the Perianal Area

Syringocystadenocarcinoma Papilliferum in the Perianal Area

Angiogenesis in Paget's Disease of the Vulva and the Breast: Correlation with Microvessel Density

Clinicopathologic characteristics of extramammary Paget’s disease of the scrotum associated with sweat gland adenocarcinoma—a clinical retrospective study

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