2014
DOI: 10.1097/pas.0000000000000088
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Mammary Analogue Secretory Carcinoma of Salivary Glands With High-grade Transformation

Abstract: Mammary analogue secretory carcinoma of salivary gland origin (MASC) is a recently described tumor resembling secretory carcinoma of the breast characterized by strong S-100 protein, mammaglobin, and vimentin immunoexpression and which harbors a t(12;15) (p13;q25) translocation resulting in ETV6-NTRK3 fusion product. Histologically, conventional MASC displays bland histomorphology and a lobulated growth pattern and is often composed of microcystic, tubular, and solid structures with abundant eosinophilic homog… Show more

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Cited by 199 publications
(85 citation statements)
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“…For acinic cell carcinoma with HGT a side by side comparison with conventional acinic cell carcinoma confirms a more aggressive behavior even when corrected for age. Secretory carcinoma and PAC have also been reported to rarely undergo high-grade transformation, which was part of the impetus to drop the term "low-grade" from PAC [9,41].…”
Section: High-grade Transformationmentioning
confidence: 99%
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“…For acinic cell carcinoma with HGT a side by side comparison with conventional acinic cell carcinoma confirms a more aggressive behavior even when corrected for age. Secretory carcinoma and PAC have also been reported to rarely undergo high-grade transformation, which was part of the impetus to drop the term "low-grade" from PAC [9,41].…”
Section: High-grade Transformationmentioning
confidence: 99%
“…Secretory carcinoma is typically indolent like acinic cell carcinoma, but may show a slightly higher lymph node metastatic rate (up to 25%) than true acinic cell carcinoma [8]. Prognostic features include stage and high-grade transformation (see below) [9]. With the expansion of selective TRK inhibitors, recognition of advanced stage cases of secretory carcinoma may eventually have direct therapeutic relevance [10].…”
Section: Secretory Carcinomamentioning
confidence: 99%
“…Both tumours consist of microcystic and solid areas with abundant vacuolated colloid-like PAS-positive secretions within the microcystic spaces. [6,7] Both tumours are triple (ER/PR/Her-2)-negative. Breast secretory carcinomas are clinically slow growing, recur locally, occur mainly in young females and generally have a favourable outcome.…”
Section: Discussionmentioning
confidence: 99%
“…[12,19] MASC is considered to be a low-grade carcinoma that is slowgrowing, painless and with a relatively favourable prognosis. [7,12] It does not usually infiltrate surrounding structures, and perineural and vascular invasion is unusual. [12] MASCs have a 15% risk of local recurrences, especially if incompletely excised.…”
Section: Discussionmentioning
confidence: 99%
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