Mammary analog secretory carcinoma of salivary glands: a report of 2 cases in the lips

Mammary analogue secretory carcinoma of salivary gland origin (MASC) is a recently described tumor with ETV6 translocation. Akin to secretory breast cancer, MASC expresses S-100 protein, mammaglobin, vimentin, and harbors a t(12;15) (p13;q25) translocation which leads to ETV6-NTRK3 fusion product. Histologically, MASC displays a lobulated growth pattern and is often composed of microcystic, tubular, and solid structures with abundant eosinophilic homogeneous or bubbly secretions. Colloidlike secretory material stains positive for periodic acidSchiff (PAS) with and without diastase and for Alcian blue. The cells of MASC are devoid of PAS-positive secretory zymogen granules. These features help to exclude the most important differential diagnostic considerations, namely acinic cell carcinoma, low-grade cribriform cystadenocarcinoma, cystadenocarcinoma (not otherwise specified), and low-grade mucoepidermoid carcinoma. To date the presence of the ETV6-NTRK3 fusion gene has not been demonstrated in any other salivary gland tumor than MASC. It is likely that MASC is more common than currently recognized and with further studies, the clinical need for molecular studies of the ETV6-NTRK3 fusion may diminish. However, molecular testing is recommended at this time to arrive at the diagnosis of MASC.

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“…Moreover, 8 new cases of MASC have been documented as case reports within last two years [15][16][17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Mammary Analogue Secretory Carcinoma of Salivary Gland Origin: An Update and Expanded Morphologic and Immunohistochemical Spectrum of Recently Described Entity

Skálová

2013

Head and Neck Pathol

130

125

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“…Recently, two cases involving the upper and lower lip have also been reported [28]. Bishop et al, suggested that most non-parotid ACCs represent misclassified MASCs as 11/14 of their non-parotid cases harboured the ETV6 rearrangement [22].…”

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confidence: 99%

Cytogenetic and immunohistochemical characterization of mammary analogue secretory carcinoma of salivary glands

Khurram¹,

Sultan-Khan²,

Atkey

et al. 2016

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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“…All publications in the English medical literature that referenced the original paper by A. Skálová and colleagues as of November 2012 were reviewed; 76 total cases of MASC had been reported at that time [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15]. These reports were reviewed for comments on MASC encapsulation, benign or malignant nature of re-classified tumors, and pattern of ETV6 rearrangement, as detected by FISH.…”

Section: Literature Reviewmentioning

confidence: 99%

“…Since the first description of mammary analogue secretory carcinoma (MASC) of the salivary glands [1], about 70 additional cases have been reported [2]. The clinicopathologic features of MASC are now well recognized and the distinctive morphology of MASC (i.e., lobular architecture with microcystic, tubular or solid growth patterns and monomorphic cells with low-grade, vesicular nuclei and eosinophilic vacuolated cytoplasm) has now been confirmed by numerous series and case reports.…”

Section: Introductionmentioning

confidence: 99%

“…While in most recent case reports and smaller series MASC was identified prospectively (likely as a part of clinical care), the majority of the larger series represent retrospective studies of archived cases [2][3][4][5]. In an attempt to bridge MASC to more established diagnostic entities, most, but not all, series explicitly indicated the original diagnoses for cases that were re-categorized as MASC.…”

Section: Introductionmentioning

confidence: 99%

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Mammary Analogue Secretory Carcinoma Mimicking Salivary Adenoma

Williams

Chiosea

2013

Head and Neck Pathol

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Mammary analogue secretory carcinoma (MASC) is a recently described salivary gland tumor characterized by ETV6 translocation. It appears that prior studies have identified MASC by reviewing salivary gland carcinomas, such as acinic cell carcinoma and adenocarcinoma, not otherwise specified. To address the possibility of MASC mimicking benign salivary neoplasms we reviewed 12 salivary gland (cyst)adenomas diagnosed prior to the discovery of MASC. One encapsulated (cyst)adenoma of the parotid gland demonstrated features of MASC. The diagnosis was confirmed by fluorescence in situ hybridization with an ETV6 break-apart probe. An unusual complex pattern of ETV6 rearrangement with duplication of the telomeric/distal ETV6 probe was identified. This case illustrates that MASC may mimic salivary (cyst)adenomas. To more accurately assess true clinical and morphologic spectrum of MASC, future studies may have to include review of salivary (cyst)adenomas. The differential diagnosis of MASC may have to be expanded to include cases resembling salivary (cyst)adenomas.

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Mammary analog secretory carcinoma of salivary glands: a report of 2 cases in the lips

Cited by 49 publications

References 12 publications

Mammary Analogue Secretory Carcinoma of Salivary Gland Origin: An Update and Expanded Morphologic and Immunohistochemical Spectrum of Recently Described Entity

Mammary Analogue Secretory Carcinoma of Salivary Gland Origin: An Update and Expanded Morphologic and Immunohistochemical Spectrum of Recently Described Entity

Cytogenetic and immunohistochemical characterization of mammary analogue secretory carcinoma of salivary glands

Mammary Analogue Secretory Carcinoma Mimicking Salivary Adenoma

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