Mammalian target of rapamycin (mTOR) signaling pathway and traumatic brain injury: A novel insight into targeted therapy

Movahedpour, Ahmad; Vakili, Omid; Khalifeh, Masoomeh; Mousavi, Pegah; Mahmoodzadeh, Amir; Taheri‐Anganeh, Mortaza; Razmeh, Saeed; Shabaninejad, Zahra; Yousefi, Fatemeh; Behrouj, Hamid; Ghasemi, Hassan; Khatami, Seyyed Hossein

doi:10.1002/cbf.3692

Cited by 23 publications

(9 citation statements)

References 141 publications

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“…Thus, autophagy activation is recently emerging as a hot topic to study neuroprotective mechanisms in chronic retinal neurodegenerative disorders (Kaarniranta et al, 2022). Similarly, given the parallelism between traumatic and chronic degenerative conditions, the activation of autophagy in the course of traumatic CNS injury is thought to produce a strong activation to elicit functional and anatomical recovery (Movahedpour et al, 2022;Zhang et al, 2022;Filippone et al, 2022;Xu et al, 2022;Kanno et al, 2022). This is partly based on the induction of stem cells (Xu et al, 2021;Maiti et al, 2019;Ceccariglia et al, 2020;Hwang et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Combined pulses of light and sound in the retina with nutraceuticals may enhance the recovery of foveal holes

Pinelli¹,

Berti²,

Scaffidi³

et al. 2022

Archives Italiennes De Biologie

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The present manuscript stems from evidence, which indicates that specific wavelength produce an activation of the autophagy pathway in the retina. These effects were recently reported to synergize with the autophagy-inducing properties of specific phytochemicals. The combined administration of photo-modulation and phytochemicals was recently shown to have a strong potential in eliciting the recovery in the course of retinal degeneration and it was suggested as a non-invasive approach named "Lugano protocol" to treat age-related macular degeneration (AMD). Recent translational findings indicate that the protective role of autophagy may extend also to acute neuronal injuries including traumatic neuronal damage. At the same time, very recent investigations indicate that autophagy activation and retinal anatomical recovery may benefit from sound exposure. Therefore, in the present study, the anatomical rescue of a traumatic neuronal loss at macular level was investigated in a patient with idiopathic macular hole by using a combined approach of physical and chemical non-invasive treatments. In detail, light exposure was administered in combination with sound pulses to the affected retina. This treatment was supplemented by phytochemicals known to act as autophagy inducers, which were administered orally for 6 months. This combined administration of light and sound with nutraceuticals reported here as Advanced Lugano's Protocol (ALP) produced a remarkable effect in the anatomical architecture of the retina affected by the macular hole. The anatomical recovery was almost complete at roughly one year after diagnosis and beginning of treatment. The structural healing of the macular hole was concomitant with a strong improvement of visual acuity and the disappearance of metamorphopsia. The present findings are discussed in the light of a synergism shown at neuronal level between light and sound in the presence of phytochemicals to stimulate autophagy and promote proliferation and neuronal differentiation of retinal stem cells.

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Section: Introductionmentioning

confidence: 99%

Combined pulses of light and sound in the retina with nutraceuticals may enhance the recovery of foveal holes

Pinelli¹,

Berti²,

Scaffidi³

et al. 2022

Archives Italiennes De Biologie

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“…Parkinson's disease (PD) is ranked as a second nervous system disease that leads to dementia when compared to AD. PD is a movement disorder that leads to resting tremors, rigidity, and bradykinesia, and is characterized by the loss of dopaminergic neurons in the substantia nigra [22,29,69,111,[117][118][119][120][121][122]. More than 10 million individuals suffer from PD in the world, which includes 50,000 new cases annually in the US, and many suffer from cognitive loss [117,123].…”

Section: Cognitive Impairment In Neurodegenerationmentioning

confidence: 99%

Cognitive Impairment in Multiple Sclerosis

Maiese

2023

Bioengineering

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Almost three million individuals suffer from multiple sclerosis (MS) throughout the world, a demyelinating disease in the nervous system with increased prevalence over the last five decades, and is now being recognized as one significant etiology of cognitive loss and dementia. Presently, disease modifying therapies can limit the rate of relapse and potentially reduce brain volume loss in patients with MS, but unfortunately cannot prevent disease progression or the onset of cognitive disability. Innovative strategies are therefore required to address areas of inflammation, immune cell activation, and cell survival that involve novel pathways of programmed cell death, mammalian forkhead transcription factors (FoxOs), the mechanistic target of rapamycin (mTOR), AMP activated protein kinase (AMPK), the silent mating type information regulation 2 homolog 1 (Saccharomyces cerevisiae) (SIRT1), and associated pathways with the apolipoprotein E (APOE-ε4) gene and severe acute respiratory syndrome coronavirus (SARS-CoV-2). These pathways are intertwined at multiple levels and can involve metabolic oversight with cellular metabolism dependent upon nicotinamide adenine dinucleotide (NAD+). Insight into the mechanisms of these pathways can provide new avenues of discovery for the therapeutic treatment of dementia and loss in cognition that occurs during MS.

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“…The overexpressed miRNAs mostly target the signaling pathways involved in the regulation of stem cell pluripotency and the TGF-β, FOXO, MAPK, and Wnt signaling pathways. However, the MAPK, TGF-β, FOXO, mTOR, and PI3K/Akt signaling pathways were found to be major targets for underexpressed miRNAs ( Sebolt-Leopold and Herrera, 2004 ; Wang et al, 2008 ; Loh et al, 2013 ; Coomans de Brachène and Demoulin, 2016 ; Dey et al, 2017 ; Chen et al, 2019a ; Movahedpour et al, 2022b ). CCND1 and PTEN are considered the most common exosomal miRNA targets with high and low expression levels, respectively ( Chen et al, 2019a ).…”

Section: Molecular Mechanisms By Which Exosomal Ncrnas Interfere With...mentioning

confidence: 99%

The landscape of exosomal non-coding RNAs in breast cancer drug resistance, focusing on underlying molecular mechanisms

et al. 2023

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Breast cancer (BC) is the most common malignancy among women worldwide. Like many other cancers, BC therapy is challenging and sometimes frustrating. In spite of the various therapeutic modalities applied to treat the cancer, drug resistance, also known as, chemoresistance, is very common in almost all BCs. Undesirably, a breast tumor might be resistant to different curative approaches (e.g., chemo- and immunotherapy) at the same period of time. Exosomes, as double membrane-bound extracellular vesicles 1) secreted from different cell species, can considerably transfer cell products and components through the bloodstream. In this context, non-coding RNAs (ncRNAs), including miRNAs, long ncRNAs (lncRNAs), and circular RNAs (circRNAs), are a chief group of exosomal constituents with amazing abilities to regulate the underlying pathogenic mechanisms of BC, such as cell proliferation, angiogenesis, invasion, metastasis, migration, and particularly drug resistance. Thereby, exosomal ncRNAs can be considered potential mediators of BC progression and drug resistance. Moreover, as the corresponding exosomal ncRNAs circulate in the bloodstream and are found in different body fluids, they can serve as foremost prognostic/diagnostic biomarkers. The current study aims to comprehensively review the most recent findings on BC-related molecular mechanisms and signaling pathways affected by exosomal miRNAs, lncRNAs, and circRNAs, with a focus on drug resistance. Also, the potential of the same exosomal ncRNAs in the diagnosis and prognosis of BC will be discussed in detail.

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Mammalian target of rapamycin (mTOR) signaling pathway and traumatic brain injury: A novel insight into targeted therapy

Cited by 23 publications

References 141 publications

Combined pulses of light and sound in the retina with nutraceuticals may enhance the recovery of foveal holes

Combined pulses of light and sound in the retina with nutraceuticals may enhance the recovery of foveal holes

Cognitive Impairment in Multiple Sclerosis

The landscape of exosomal non-coding RNAs in breast cancer drug resistance, focusing on underlying molecular mechanisms

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